Abstract: Apparatus and processes to grow a biomaterial made of aerial mycelium by sensing and controlling airborne mist concentration, regardless of relative humidity. A growth matrix comprising a growth medium and a fungus, is grown under controlled environmental conditions to produce a mycelium product. To control growth conditions precisely and efficiently, airborne mist is electronically detected using one or more sensors, configured to measure airborne mist concentration visually, optically, chemically, electromagnetically, or by laser, ultrasonically, with radar, or other means. Electronic detection of airborne mist using one or more sensors generates a signal that is transmitted to a processor that can either maintain, increase, or decrease airborne mist concentration in a growth environment. The present invention provides processes of growing mycelium that are repeatable and resource efficient, while providing high quality and quantity mycelium-based products.

Abstract: Automated cold storage unit and systems for storing, monitoring, and maintaining a supply of temperature sensitive pharmaceutical and/or other products in compliance with regulatory requirements are provided. Such units contain an array of independently addressable holding locations for containers with product in one or more controlled temperature zones fitted with temperature sensors. The units include a reader to track product information and status. Product movement within the unit is performed by a computer-controlled robot. A user interface device, preferably in communication with an application service provider to provide remotely managed inventory management and other services, provides users with secure access to the contents of the unit and associated product data and information.

Abstract: Disclosed are a method and system for propagating data changes in a hierarchy of dataset models in which each dataset model comprises an analytic and one or more parent datasets, including a primordial dataset. The analytic is executed to instantiate a first instance of the data model. After a change in a primordial dataset, each instance of a dataset model that descends from the primordial dataset is invalidated, and the analytic is re-executed to create a second instance of the data model. Analytical results may be displayed. The first dataset model may include a metric in which the definition of the metric comprises metadata of the dataset model. Metric values may be stored in a first cache, re-computed on a new instance of the dataset model, and stored in a second cache.

Abstract: A method for transferring heat between a first fluid and a second fluid includes providing a tubeless heat exchanger having a tubeless heat exchanger core, the tubeless heat exchanger core having an inner casing and an outer casing disposed around the inner casing, the inner and outer casings defining therebetween a flow passage for a thermal transfer fluid to flow, the tubeless heat exchanger core having a core inlet arranged to receive the first fluid and a core outlet arranged to provide the first fluid, the core inlet and core outlet being fluidically connected to the flow passage, and at least one of the core inlet and core outlet being disposed on the inner casing, wherein each of the outer casing and the inner casing has an inner surface and an outer surface, wherein the respective inner surfaces face each other and define therebetween the flow passage for the first fluid to flow from the core inlet to the core outlet and wherein at least a portion of the respective outer surfaces are arranged to be co

Abstract: A method for transferring heat between a first fluid and a second fluid includes providing a tubeless heat exchanger having a tubeless heat exchanger core, the tubeless heat exchanger core having an inner casing and an outer casing disposed around the inner casing, the inner and outer casings defining therebetween a flow passage for a thermal transfer fluid to flow, the tubeless heat exchanger core having a core inlet arranged to receive the first fluid and a core outlet arranged to provide the first fluid, the core inlet and core outlet being fluidically connected to the flow passage, and at least one of the core inlet and core outlet being disposed on the inner casing, wherein each of the outer casing and the inner casing has an inner surface and an outer surface, wherein the respective inner surfaces face each other and define therebetween the flow passage for the first fluid to flow from the core inlet to the core outlet and wherein at least a portion of the respective outer surfaces are arranged to be co

Abstract: Automated cold storage unit and systems for storing, monitoring, and maintaining a supply of temperature sensitive pharmaceutical and/or other products in compliance with regulatory requirements are provided. Such units contain an array of independently addressable holding locations for containers with product in one or more controlled temperature zones fitted with temperature sensors. The units include a reader to track product information and status. Product movement within the unit is performed by a computer-controlled robot. A user interface device, preferably in communication with an application service provider to provide remotely managed inventory management and other services, provides users with secure access to the contents of the unit and associated product data and information.

Abstract: Techniques are described for managing preloading of data for client computing systems. A client computing system may provide one or more persistent data storage caches on local storage, such as to support a particular software program executing on the client computing system (e.g., a Web browser program, with the persistent data storage cache designed to store browser cookies and other data for later access by the Web browser program). Additional data may be stored in such a persistent data storage cache by preloading those data groups before they are requested by the client computing system (e.g., based on interactions of a user of the client computing system with an executing program on the client computing system). Particular data groups to preload may be selected in various manners, including to provide a specified type of minimum functionality to a client computing system based on the preloaded data groups.

Abstract: A method for transferring heat between a first fluid and a second fluid includes providing a tubeless heat exchanger having a tubeless heat exchanger core, the tubeless heat exchanger core having an inner casing and an outer casing disposed around the inner casing, the inner and outer casings defining therebetween a flow passage for a thermal transfer fluid to flow, the tubeless heat exchanger core having a core inlet arranged to receive the first fluid and a core outlet arranged to provide the first fluid, the core inlet and core outlet being fluidically connected to the flow passage, and at least one of the core inlet and core outlet being disposed on the inner casing, wherein each of the outer casing and the inner casing has an inner surface and an outer surface, wherein the respective inner surfaces face each other and define therebetween the flow passage for the first fluid to flow from the core inlet to the core outlet and wherein at least a portion of the respective outer surfaces are arranged to be co

Abstract: A method for transferring heat between a first fluid and a second fluid includes providing a tubeless heat exchanger having a tubeless heat exchanger core, the tubeless heat exchanger core having an inner casing and an outer casing disposed around the inner casing, the inner and outer casings defining therebetween a flow passage for a thermal transfer fluid to flow, the tubeless heat exchanger core having a core inlet arranged to receive the first fluid and a core outlet arranged to provide the first fluid, the core inlet and core outlet being fluidically connected to the flow passage, and at least one of the core inlet and core outlet being disposed on the inner casing, wherein each of the outer casing and the inner casing has an inner surface and an outer surface, wherein the respective inner surfaces face each other and define therebetween the flow passage for the first fluid to flow from the core inlet to the core outlet and wherein at least a portion of the respective outer surfaces are arranged to be co

Abstract: Automated cold storage unit and systems for storing, monitoring, and maintaining a supply of temperature sensitive pharmaceutical and/or other products in compliance with regulatory requirements are provided. Such units contain an array of independently addressable holding locations for containers with product in one or more controlled temperature zones fitted with temperature sensors. The units include a reader to track product information and status. Product movement within the unit is performed by a computer-controlled robot. A user interface device, preferably in communication with an application service provider to provide remotely managed inventory management and other services, provides users with secure access to the contents of the unit and associated product data and information.

Abstract: Methods and systems to predict a supply chain performance are described. A system receives supply chain data for delivery of a product. The supply chain data includes input signals comprising operational plans and observed supply chain operational metrics. The input signals include a delivery date of the product. The system automatically generating predicted supply chain operational metrics across including a value at risk that is predicted for the product. The system automatically infers causal factors that impact the predicted supply chain operational metrics including impacting the value at risk that is predicted for the product. The system automatically generates action recommendations for the supply chain. An action recommendation includes a first predicted value impact and a sequence of actions impacting the product the delivery date of the product and the value at risk that is predicted for the product.

Abstract: Disclosed are a method and system for propagating data changes in a hierarchy of dataset models in which each dataset model comprises an analytic and one or more parent datasets, including a primordial dataset. The analytic is executed to instantiate a first instance of the data model. After a change in a primordial dataset, each instance of a dataset model that descends from the primordial dataset is invalidated, and the analytic is re-executed to create a second instance of the data model. Analytical results may be displayed. The first dataset model may include a metric in which the definition of the metric comprises metadata of the dataset model. Metric values may be stored in a first cache, re-computed on a new instance of the dataset model, and stored in a second cache.

Abstract: An exemplary device for collecting cervicovaginal cells includes a proximal end portion configured for gripping by a user, a distal end portion configured for contacting an ectocervical region and obtaining a sampling of cells therefrom, an elongated body portion extending between and connecting the proximal end portion and the distal end portion, and an elongated slot sized and shaped to receive a bristled portion of a brush having disposed thereon endocervical cells.

Abstract: A power electronics assembly may include a power component having a thermally and electrically conductive surface; a printed circuit board having a slot; and a bussing element having a protrusion that directly contacts the thermally and electrically conductive surface of the power component via the slot of the printed circuit board, the printed circuit board being disposed between the power component and the bussing element.

Abstract: Disclosed are a method and system for propagating data changes in a hierarchy of dataset models in which each dataset model comprises an analytic and one or more parent datasets, including a primordial dataset. The analytic is executed to instantiate a first instance of the data model. After a change in a primordial dataset, each instance of a dataset model that descends from the primordial dataset is invalidated, and the analytic is re-executed to create a second instance of the data model. Analytical results may be displayed. The first dataset model may include a metric in which the definition of the metric comprises metadata of the dataset model. Metric values may be stored in a first cache, re-computed on a new instance of the dataset model, and stored in a second cache.

Abstract: A power electronics assembly may include a power component having a thermally and electrically conductive surface; a printed circuit board having a slot; and a bussing element having a protrusion that directly contacts the thermally and electrically conductive surface of the power component via the slot of the printed circuit board, the printed circuit board being disposed between the power component and the bussing element.

Abstract: A fluid heating system including: a pressure vessel shell com including prising a first inlet; a heat exchanger disposed in the pressure vessel shell, the heat exchanger including a second inlet and a second outlet, wherein the second inlet of the heat exchanger is connected to the first inlet of the pressure vessel shell; and an exhaust manifold disposed in the pressure vessel shell, the exhaust manifold including a third inlet and a third outlet, wherein the third inlet of the exhaust manifold is connected to the second outlet of the heat exchanger, wherein the third outlet of the exhaust manifold is outside of the pressure vessel shell, and wherein the exhaust manifold penetrates the pressure vessel shell.

Abstract: This disclosure relates to phosphoinositide 3-kinases (PI3Ks) inhibitors such as N-(5-(imidazo[1,2-a]pyridin-6-yl)pyridin-3-yl)sulfonamide derivatives and uses related thereto. In certain embodiments, the disclosure relates to methods of treating PI3K associated diseases or conditions comprising administering an effective amount of a compound disclosed herein to a subject in need thereof. In certain embodiments, the subject is at risk of, exhibiting symptoms of, suffering from, or diagnosed with cancer or a hematological malignancy.

Abstract: Automated cold storage unit and systems for storing, monitoring, and maintaining a supply of temperature sensitive pharmaceutical and/or other products in compliance with regulatory requirements are provided. Such units contain an array of independently addressable holding locations for containers with product in one or more controlled temperature zones fitted with temperature sensors. The units include a reader to track product information and status. Product movement within the unit is performed by a computer-controlled robot. A user interface device, preferably in communication with an application service provider to provide remotely managed inventory management and other services, provides users with secure access to the contents of the unit and associated product data and information.