Abstract: Pharmacuetical Compounds Benzodiazepine derivatives of formula (I): wherein: R1 is H or F; R2 is selected from formula (II) and formula (III) R3 is C1-C6 alkyl which is unsubstituted or substituted by CF3, or is a monocyclic 4- to 6-membered heterocyclic group containing 1 or 2 heteroatoms selected from O, N and S; R4 is H or a group selected from —X, -alk-X, —CONR6R7, C?NNR6R7, —SO2R6 and —SO2NR6R7; R4 is a group selected from —X, -alk-X, —CONR6R7, —C?NNR6R7, —SO2R6 and —SO2R6R7; X is OH or a derivative of an OH group selected from ?-amino carboxylic acid esters, carboxylic acid esters, carbonates, carbamates, ethers and phosphates: alk is C1-C6 alkylene which is unsubstituted or substituted by C3-C6 cycloalkyl; and R6 and R7 are each independently C1-C6 alkyl or C3-C6 cycloalkyl; and the pharmaceutically acceptable salts thereof are inhibitors of respiratory syncytial virus (RSV) and can therefore be used to treat or prevent an RSV infection.

Abstract: A system, method, and computer readable medium receive a container image and an attestation log. The container image is built from a build pipeline and the attestation log includes information corresponding to tasks utilized by the build pipeline to build the container image. The system, method, and computer readable medium compare the information in the attestation log with policies that includes build pipeline requirements. The system, method, and computer readable medium release the container image to a destination based on the comparison indicating that tasks utilized by the build pipeline to build the container image meet the build pipeline requirements.

Abstract: The present disclosure relates to a data processing device comprising means configured for adapting a regulated digital platform, the data processing device (120) being arranged to monitor and adapt said digital platform (110); obtain user profile data (121) indicative of interactions with said digital platform (110) associated with a user profile (111); determine a set of platform risk values (122) based on the obtained user profile data (121) and said digital platform (110), wherein said set of platform risk values (122) is indicative of at least one risk associated with said digital platform (110) for said user profile (111); and adapt said digital platform (110) for at least said user profile (111) based on the determined set of platform risk values (122), and/or determine a set of aggregate platform risk values for the digital platform (110) based on at least the determined set of platform risk values (122).

Abstract: Systems and methods for using dynamic actionable notifications are disclosed. The method includes: receiving, at a client device, a dynamic actionable notification associated with an event at a remote server, the dynamic actionable notification including one or more action items associated with the event; detecting user interaction with the dynamic actionable notification; retrieving current status of the one or more action items from the remote server; displaying one or more actionable graphical elements in a user interface of the dynamic actionable notification based on the retrieved current status of the one or more action items.

Abstract: A system and method for motion capture to efficiently render in-game objects, including characters, and controlling animation of characters and non-player characters. In some embodiments, the motion capture includes a machine learning model that can take as inputs information about the hand pose of a person from multiple sensors over a period of time and generates a highly probable hand pose prediction from that information, based on what it learns from a previously captured dataset of high quality sample motion captures. The systems and methods described herein overcome the imprecision conventional optical marker pipelines for the case of finger movement, where the slightest imprecision yields results that are not good enough for production.

Abstract: A diffuser for use with a wound retractor and configured to deliver gases includes an interface tube for connecting to a gases supply and a diffuser interface positioned at a proximal end of the interface tube, the diffuser interface configured for delivering gases received from the gases supply through the interface tube, and the diffuser interface comprising a diffusion mechanism configured to deliver gases in a diffusion direction. A wound retractor with an integrated diffuser is also disclosed. The wound retractor includes an upper ring, a lower ring, a sleeve extending between and connecting the upper ring to the lower ring, and an integrated diffuser interface having a gases inlet and a diffusion mechanism.

Abstract: A parking meter may incorporate a touchscreen display assembly that uses a low-power wake trigger, which may be a proximity sensor overlaid on the display, that can power on the display and touch sensor when a user's proximity is detected. The parking meter may incorporate a replaceable panel insert that allows user interface components to be easily retrofitted or upgraded by simply replacing the panel insert. Additionally, the parking meter may incorporate multiple solar panels on the exterior of the parking meter.

Abstract: A framing tool supports one end of beam member while the other end of the beam is secured to another beam or structure. The framing tool includes a support portion, a receiving portion and a strap. The strap wraps around a beam member to secure the beam member within the receiving portion. The support portion holds one end of the beam member in place so that an installer may secure the other end of the beam member without the aid of another installer.

Abstract: Oil field resources are allocated using machine learning and optimization. A well of a set of wells is identified. A user interface is presented to obtain a priority of a set of priorities. A schedule is generated for a set of resources for a job using the priority. A job schedule is presented that includes a set of jobs for the set of wells. The job schedule is generated using the set of priorities. An update to the priority is obtained. An updated job schedule is presented based on the update to the priority.

Abstract: A prosthetic hip replacement assembly comprises a femoral stem, a femoral head adapted to be fixedly secured to the femoral stem, an acetabular shell adapted to be inserted into a surgically prepared acetabulum, and a liner fixedly secured within the acetabular shell and within which the femoral head is adapted to fully articulate. The femoral head comprises a ball, a highly porous coating, and a plastic coating formed upon the highly porous coating such that the plastic coating can infiltrate the pores of the highly porous coating whereby the femoral head comprises a monobloc structure comprising the ball, the highly porous coating, and the plastic coating. In an alternative embodiment, the liner can be eliminated.

Abstract: One example food preparation appliance includes a base having a motor and an adaptor, a weight sensor coupled to the adaptor, and a communication component. The adaptor is configured to support a food preparation accessory. The weight sensor is configured to detect a weight applied to the adaptor. The communication component is configured to transmit data associated with a weight detected by the weight sensor. An example remote communication device includes a display device, a processor; and a memory coupled to the processor. The remote communication device is configured to display a first instruction on the display device, the first instruction including a first target weight of a first substance; receive a measurement from a food preparation appliance indicative of a weight applied to an adaptor of the food preparation appliance; and display a second instruction when the weight is substantially equal to the first target weight.

Abstract: A suction tip and tubing aspirator is disclosed and comprises a first lumen having a first open end adapted to be operatively connected to a source of suction, and a second open end adapted to be inserted into a site from which tissue or debris is to be aspirationally removed, a second lumen integrally connected to the first lumen, and a stylus movably disposed within the second lumen between retracted and extended positions such that when the stylus is moved from the retracted position to the extended position, a distal end portion of the stylus will protrude outwardly from the second end of the first lumen so as to remove any tissue or debris which has clogged, blocked, or occluded the second open end of said first lumen.

Abstract: Methods for treating or preventing kidney diseases and fibrosis, such as chronic kidney disease (CKD), kidney fibrosis, heart fibrosis, uterine fibrosis, and cystic fibrosis, with compounds of Formulae (I), (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH), (IJ), (II), (III), (IIIA), and (IIIB); pharmaceutically acceptable salts and solvates thereof; and compositions thereof.

Abstract: This invention provides methods for treating or preventing kidney diseases and fibrosis, such as chronic kidney disease (CKD), kidney fibrosis, heart fibrosis, uterine fibrosis, and cystic fibrosis, with compounds of Formulae (I), (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH), (IJ), (II), (III), (IIIA), and (IIIB); pharmaceutically acceptable salts and solvates thereof; and compositions thereof.

Abstract: Assembly of harness and sensor substrate plates for monitoring vital signals of a patient is provided. More specifically, the present invention provides a harness, a sensor substrate plate, and related devices for non-invasively monitoring vital signals of a patient. The sensor substrate plate provides removable attachment to the skin of a patient to measure vital signals of the patient. The sensor substrate plate comprises an elongated main body comprising an upper surface and an under surface. The upper surface is configured to removably contact the skin surface of the patient. Further, a plurality of slots on the upper surface of the main body is mechanically and electrically configured to hold sensors or electrodes for monitoring biometric parameters of the patient. The upper surface also includes a first through hole mechanically and electrically configured to hold an electrical connector; and a first end and a second end of the main body.

Abstract: A system and method for controlling the animation and movement of in-game objects. In some embodiments, the system includes one or more data-driven animation building blocks that can be used to define any character movements. In some embodiments, the data-driven animation blocks are conditioned by how their data is described separately from any explicit code in the core game engine. These building blocks can accept certain inputs from the core code system (e.g., movement direction, desired velocity of movement, and so on). But the game itself is agnostic as to why particular building blocks are used and what animation data (e.g., single animation, parametric blend, defined by user, and so on) the blocks may be associated with.

Abstract: A power generation system includes one or more micro-turbine electric generators (“MTEGs”). The MTEGs include a housing having an inlet for receiving pressurized gas and an outlet for releasing expanded gas. The MTEGs also include a rotor, a user-replaceable nozzle for directing pressurized gas over blades of the rotor, and a stator for generating alternating current (“AC”) responsive to rotation of the rotor. The power generation system also includes a programmable logic controller (“PLC”) coupled to the MTEGs that operates flow control valves (“FCVs”) coupled to the MTEGs to modulate the flow of gas to the MTEGs to generate output power suitable to support an electrical load. The system also includes power conversion circuitry configured to convert AC generated by the MTEGs to direct current (“DC”) and to provide the DC to an electrical load. The system also includes a skid for mounting multiple and MTEGs and FCVs.

Abstract: The invention relates to a container (1) for use in a beverage preparation machine. The container (1) has a non-symmetrical shape such that it is inserted functionally inside the beverage preparation machine with a specific orientation. The container (1) comprises a container body (2) having a back side (40) and a front side (3), the back side (40) and the front side (3) delimiting a compartment adapted to be traversed by water injected therein by the beverage preparation machine through the back side (40), and a plant material for preparing a tea beverage, the plant material being inside said compartment.

Abstract: Systems and methods relating to patch antennas. A patch antenna has a substrate, a resonant metal plate at one side of the substrate, and a ground plane at the other opposite side of the substrate. Two feed pins are used to couple the antenna to other circuitry. The feed pins pass through the substrate and holes in at the ground plane. The feed pins are physically disconnected from both the resonant metal plate and the ground plane. The feed pins are capacitively coupled to the resonant metal plate to provide an electronic connection between other circuitry and the patch antenna.

Abstract: Systems and methods may determine an amount of current being drawn by a light source and determine, based on the amount of current, a type of light source. Based on the type of light source, an amount of time associated with disabling the light source may be determined. A voltage may be supplied to the light source for the amount of time.