Patents by Inventor James T. Stivers

James T. Stivers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Rapid fluorescence detection of binding to nucleic acid drug targets labelled with highly fluorescent nucleotide base analogs
    Patent number: 6743586
    Abstract: The present invention is a method of identifying ligands that interact will cellular processes involved in the life-cycle of HIV. In particular, an oligonucleotide, corresponding to specific RNA sequence within an infected cell, is modified by the substitution of 2-aminopurine. As a result, interactions between the oligonucleotide and the ligand can be measured via fluorescence. This technique can be use to find inhibitors of binding between rev and its response element (RRE), dimerization initiation sequences, and topoisomerases and DNA.
    Type: Grant
    Filed: October 25, 2001
    Date of Patent: June 1, 2004
    Assignee: The United States of America as represented by the Secretary of the Commerce
    Inventors: John P. Marino, James T. Stivers, Karen Lacourciere
  • Rapid fluorescence detection of binding to nucleic acid drug targets labelled with highly fluorescent nuclotide base analogs
    Publication number: 20030165846
    Abstract: The present invention is a method of identifying ligands that interact will cellular processes involved in the life-cycle of HIV. In particular, an oligonucleotide, corresponding to specific RNA sequence within an infected cell, is modified by the substitution of 2-aminopurine. As a result, interactions between the oligonucleotide and the ligand can be measured via fluorescence. This technique can be use to find inhibitors of binding between rev and its response element (RRE), dimerization initiation sequences, and topoisomerases and DNA.
    Type: Application
    Filed: October 25, 2001
    Publication date: September 4, 2003
    Inventors: John P. Marino, James T. Stivers, Karen Lacourciere