Abstract: The invention relates to SCUBE molecules and generally to gene expression in vascular endothelial cells. The invention specifically relates to the discovery of a novel gene family containing the genes and proteins referred to herein as SCUBE1, SCUBE2 and SCUBE3 which can be expressed in endothelial cells. SCUBE proteins may be involved in the development of cardiovascular disease, hemostasis, thrombosis, inflammatory disease, bone metabolism disorders, urinary bladder disorders and breast disorders.

Abstract: A device and methods for the rapid chemiluminescence or calorimetric assay of surfaces to detect the presence of microbial or protein contamination is disclosed. A sampling/analysis member (10) is described having a sampling wand (15) which is suitable for use by untrained personnel under the relatively harsh and variable conditions found in the field, for example in fast food restaurants and other food preparation areas. The analytical signal in the disclosed device and methods can be based on luciferase/luciferin systems or a protein assay systems utilizing bicinchoninic acid.