Patents by Inventor James Versalovic
James Versalovic has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230241136Abstract: The invention herein discloses histamine-producing bacterial strains for use in the prophylaxis, inhibition, treatment or reducing a risk of relapse of cancer, including colorectal cancer. The present invention also discloses the use of histamine-producing bacterial strains for manufacturing a medicament for treatment of cancer, including male colorectal cancer.Type: ApplicationFiled: December 1, 2022Publication date: August 3, 2023Inventors: James Versalovic, Bo Mollstam, Chunxu Gao, Bhanu Priya Ganesh
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Publication number: 20220008491Abstract: Bacterial strains useful in prophylaxis, inhibition and/or treatment of an allergy in a mammal are selected by screening bacterial strains for capability of producing diacylglycerol kinase (DagK). A bacterial strain which is capable of producing DagK is then selected for use in prophylaxis, inhibition and/or treatment of the allergy.Type: ApplicationFiled: August 31, 2021Publication date: January 13, 2022Inventors: James Versalovic, Bo Mollstam, Bhanu Priya Ganesh
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Patent number: 11135255Abstract: Bacterial strains useful in prophylaxis, inhibition and/or treatment of an allergy in a mammal are selected by screening bacterial strains for capability of producing diacylglycerol kinase (DagK). A bacterial strain which is capable of producing DagK is then selected for use in prophylaxis, inhibition and/or treatment of the allergy.Type: GrantFiled: May 8, 2017Date of Patent: October 5, 2021Assignee: BIOGAIA ABInventors: James Versalovic, Bo Mollstam, Bhanu Priya Ganesh
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Patent number: 10898529Abstract: A method is provided of selecting specific probiotic lactic acid bacteria producing histamine and the use of such strains for beneficial effects for mammals. The method includes selecting a lactic acid bacterial strain for use in the local production of histamine in a mammal, and further comprises screening bacteria for the presence of an active histidine operon and selecting a strain which has an active histidine operon and is capable of producing histamine. Preferably said strain is selected for its ability to produce histamine at a level of greater than 250 pg/ml. The present invention further provides products comprising the strains obtainable by the selection methods of the invention for use in the local production of histamine in a mammal, in particular for use in the treatment or prophylaxis of inflammatory conditions.Type: GrantFiled: May 23, 2018Date of Patent: January 26, 2021Assignee: BIOGAIA ABInventors: James Versalovic, Carissa Michelle Thomas, Eamonn Connolly
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Publication number: 20190142877Abstract: Bacterial strains useful in prophylaxis, inhibition and/or treatment of an allergy in a mammal are selected by screening bacterial strains for capability of producing diacylglycerol kinase (DagK). A bacterial strain which is capable of producing DagK is then selected for use in prophylaxis, inhibition and/or treatment of the allergy.Type: ApplicationFiled: May 8, 2017Publication date: May 16, 2019Inventors: James Versalovic, Bo Mollstam, Bhanu Priya Ganesh
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Publication number: 20180264055Abstract: A method is provided of selecting specific probiotic lactic acid bacteria producing histamine and the use of such strains for beneficial effects for mammals. The method includes selecting a lactic acid bacterial strain for use in the local production of histamine in a mammal, and further comprises screening bacteria for the presence of an active histidine operon and selecting a strain which has an active histidine operon and is capable of producing histamine. Preferably said strain is selected for its ability to produce histamine at a level of greater than 250 pg/ml. The present invention further provides products comprising the strains obtainable by the selection methods of the invention for use in the local production of histamine in a mammal, in particular for use in the treatment or prophylaxis of inflammatory conditions.Type: ApplicationFiled: May 23, 2018Publication date: September 20, 2018Inventors: James Versalovic, Carissa Michelle Thomas, Eamonn Connolly
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Patent number: 10004770Abstract: A method is provided of selecting specific probiotic lactic acid bacteria producing histamine and the use of such strains for beneficial effects for mammals. The method includes selecting a lactic acid bacterial strain for use in the local production of histamine in a mammal, and further comprises screening bacteria for the presence of an active histidine operon and selecting a strain which has an active histidine operon and is capable of producing histamine. Preferably said strain is selected for its ability to produce histamine at a level of greater than 250 pg/ml. The present invention further provides products comprising the strains obtainable by the selection methods of the invention for use in the local production of histamine in a mammal, in particular for use in the treatment or prophylaxis of inflammatory conditions.Type: GrantFiled: October 10, 2016Date of Patent: June 26, 2018Assignee: BIOGAIA ABInventors: James Versalovic, Carissa Michelle Thomas, Eamonn Connolly
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Publication number: 20180104287Abstract: The invention herein discloses histamine-producing bacterial strains for use in the prophylaxis, inhibition, treatment or reducing a risk of relapse of cancer, including colorectal cancer. The present invention also discloses the use of histamine-producing bacterial strains for manufacturing a medicament for treatment of cancer, including male colorectal cancer.Type: ApplicationFiled: March 24, 2016Publication date: April 19, 2018Inventors: James VERSALOVIC, Bo MÖLLSTAM, Chunxu GAO, Bhanu GANESH
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Publication number: 20170020936Abstract: A method is provided of selecting specific probiotic lactic acid bacteria producing histamine and the use of such strains for beneficial effects for mammals. The method includes selecting a lactic acid bacterial strain for use in the local production of histamine in a mammal, and further comprises screening bacteria for the presence of an active histidine operon and selecting a strain which has an active histidine operon and is capable of producing histamine. Preferably said strain is selected for its ability to produce histamine at a level of greater than 250 pg/ml. The present invention further provides products comprising the strains obtainable by the selection methods of the invention for use in the local production of histamine in a mammal, in particular for use in the treatment or prophylaxis of inflammatory conditions.Type: ApplicationFiled: October 10, 2016Publication date: January 26, 2017Inventors: James Versalovic, Carissa Michelle Thomas, Eamonn Connolly
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Publication number: 20140065696Abstract: A specific method is provided of improving immunomodulatory properties of Lactobacillus strains using growth media with a specific primary carbon source, including a method of increasing the anti-inflammatory effect of non-pathogenic anti-inflammatory bacterial strains, by the use of specific growth conditions.Type: ApplicationFiled: November 7, 2013Publication date: March 6, 2014Inventors: Delphine Saulnier, James Versalovic, Bo Mollstam
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Publication number: 20130149291Abstract: A method is provided of selecting specific probiotic lactic acid bacteria producing histamine and the use of such strains for beneficial effects for mammals. The method includes selecting a lactic acid bacterial strain for use in the local production of histamine in a mammal, and further comprises screening bacteria for the presence of an. active histidine operon and selecting a strain which has an active histidine operon and is capable of producing histamine. Preferably said strain is selected for its ability to produce histamine at a level of greater than 250 pg/ml. The present invention further provides products comprising the strains obtainable by the selection methods of the invention for use in the local production, of histamine in a mammal, in particular for use in the treatment or prophylaxis of inflammatory conditions.Type: ApplicationFiled: February 13, 2013Publication date: June 13, 2013Inventors: James Versalovic, Carissa Michelle Thomas, Eamonn Connolly
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Publication number: 20130022586Abstract: A method is provided of selecting specific probiotic lactic acid bacteria producing histamine and the use of such strains for beneficial effects for mammals. The method includes selecting a lactic acid bacterial strain for use in the local production of histamine in a mammal, and further comprises screening bacteria for the presence of an active histidine operon and selecting a strain which has an active histidine operon and is capable of producing histamine. Preferably said strain is selected for its ability to produce histamine at a level of greater than 250 pg/ml. The present invention further provides products comprising the strains obtainable by the selection methods of the invention for use in the local production of histamine in a mammal, in particular for use in the treatment or prophylaxis of inflammatory conditions.Type: ApplicationFiled: July 19, 2012Publication date: January 24, 2013Inventors: James Versalovic, Carissa Michelle Thomas, Eamonn Connolly
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Publication number: 20110293710Abstract: A specific method is provided of improving immunomodulatory properties of Lactobacillus strains using growth media with a specific primary carbon source, including a method of increasing the anti-inflammatory effect of non-pathogenic anti-inflammatory bacterial strains, by the use of specific growth conditions.Type: ApplicationFiled: February 1, 2011Publication date: December 1, 2011Inventors: Delphine Saulnier, James Versalovic, Bo Mollstam
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Publication number: 20090136454Abstract: In the present invention, lactic acid bacteria produce soluble factors (such as peptides or proteins) that block inflammatory responses in a mechanism that depends on G proteins and is post-transcriptional to effectively block protein production or secretion by cells.Type: ApplicationFiled: February 7, 2008Publication date: May 28, 2009Inventors: James Versalovic, Jeremy A. Pena, Ramonn Connolly
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Publication number: 20040208863Abstract: In the present invention, lactic acid bacteria produce soluble factors (such as peptides or proteins) that block inflammatory responses in a mechanism that depends on G proteins and is post-transcriptional to effectively block protein production or secretion by cells.Type: ApplicationFiled: January 29, 2004Publication date: October 21, 2004Inventors: James Versalovic, Jeremy A. Pena, Eamonn Connolly
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Patent number: 5691136Abstract: Oligonucleotide primers and methods for identifying strains of bacteria by genomic fingerprinting are described. The methods are applicable to a variety of samples. The testing procedure includes amplifying the bacterial DNA in the sample to be tested by adding a pair of outwardly-directed primers to the sample. The primers are capable of hybridizing to repetitive DNA sequences in the bacterial DNA and extending outwardly from one hybridizable repetitive sequence to another hybridizable repetitive sequence. After amplification the extension products are separated by size and the specific strain of bacteria is determined by measuring the pattern of sized extension products. The procedure to identify strains of bacteria by fingerprinting has a variety of uses including: identifying bacteria in infections, agriculture and horticulture plots, bioremediation, food monitoring, production monitoring and quality assurance and quality control.Type: GrantFiled: August 24, 1993Date of Patent: November 25, 1997Assignee: Baylor College of MedicineInventors: James R. Lupski, James Versalovic, Thearith Koeuth
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Patent number: 5523217Abstract: Oligonucleotide primers and methods for identifying strains of bacteria by genomic fingerprinting are described. The methods are applicable to a variety of samples. The testing procedure includes amplifying the bacterial DNA in the sample to be tested by adding a pair of outwardly-directed primers to the sample. The primers are capable of hybridizing to repetitive DNA sequences in the bacterial DNA and extending outwardly from one hybridizable repetitive sequence to another hybridizable repetitive sequence. After amplification the extension products are separated by size and the specific strain of bacteria is determined by measuring the pattern of sized extension products. The procedure to identify strains of bacteria by fingerprinting has a variety of uses including: identifying bacteria in infections, agriculture and horticulture plots, bioremediation, food monitoring, production monitoring and quality assurance and quality control.Type: GrantFiled: May 25, 1994Date of Patent: June 4, 1996Assignee: Baylor College of MedicineInventors: James R. Lupski, Thearith Koeuth, James Versalovic