Patents by Inventor James W. Fett

James W. Fett has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antisense inhibition of angiogenin expression
    Publication number: 20020019359
    Abstract: Disclosed are oligonucleotide compounds that inhibit the expression of angiogenin when administered to a mammal. Also disclosed are methods and pharmaceutical compositions for inhibiting the expression of angiogenin useful in therapy or diagnosis.
    Type: Application
    Filed: May 23, 2001
    Publication date: February 14, 2002
    Applicant: President and Fellows of Harvard College
    Inventors: James W. Fett, Karen A. Olson
  • CHEMERIC AND HUMANIZED ANTIBODIES TO ANGIOGENIN
    Publication number: 20020010320
    Abstract: This invention relates to the production of chimeric and humanized antibodies that are immunologically reactive to angiogenin or to fragments thereof. This invention also relates to methods of inhibiting angiogenesis in mammals by administering chimeric and humanized antibodies, or Fab or F(ab′)2 fragments thereof, so as to inhibit angiogenic activity. In addition, this invention relates to a pharmaceutical composition comprising therapeutically effective amounts of a chimeric or humanized antibody that is immunologically reactive with angiogenin and which can be administered to inhibit angiogenesis.
    Type: Application
    Filed: April 5, 1999
    Publication date: January 24, 2002
    Inventor: JAMES W. FETT
  • Antisense inhibition of angiogenin expression
    Patent number: 6265388
    Abstract: Disclosed are oligonucleotide compounds that inhibit the expression of angiogenin when administered to a mammal. Also disclosed are methods and pharmaceutical compositions for inhibiting the expression of angiogenin useful in therapy or diagnosis.
    Type: Grant
    Filed: March 20, 1998
    Date of Patent: July 24, 2001
    Assignee: President and Fellows of Harvard College
    Inventors: James W. Fett, Karen A. Olson
  • Antibodies to angiogenin: immunotherapeutic agents
    Patent number: 5520914
    Abstract: This invention relates to the production of antibodies to angiogenin or to fragments thereof and to methods of inhibiting angiogenesis in mammals by administering to mammals such antibodies or Fab or F(ab').sub.2 fragments thereof so as to inhibit angiogenic activity. In addition, this invention relates to pharmaceutical compositions comprising therapeutically effective amounts of antibody that are immunologically reactive with angiogenin and which can be administered to inhibit angiogenesis.
    Type: Grant
    Filed: January 24, 1995
    Date of Patent: May 28, 1996
    Assignee: President and Fellows of Harvard College
    Inventors: James W. Fett, Bert L. Vallee, Edward M. Alderman
  • Purified protein having angiogenic activity and methods of preparation
    Patent number: 4897464
    Abstract: A substantially pure protein having angiogenic activity is disclosed. A method for preparing proteins having angiogenic activity from cell culture media is also disclosed. Proteins produced according to the invention are useful in the diagnosis of malignancies, for promoting wound healing, and for other diagnositc and therapeutic purposes.
    Type: Grant
    Filed: June 25, 1987
    Date of Patent: January 30, 1990
    Assignee: President and Fellows of Harvard College
    Inventors: Bert L. Vallee, James W. Fett
  • Method of isolating tumor-secreted products using a novel protein-free medium
    Patent number: 4879222
    Abstract: A medium for the maintenance of mammalian anchorage-dependent colonic adenocarcinoma cells comprising a solution of an effective maintenance amount of buffered salts, L-glutamine and glucose, which is devoid of exogenous protein. The medium further includes a solution containing amino acids.
    Type: Grant
    Filed: August 28, 1986
    Date of Patent: November 7, 1989
    Assignee: President and Fellows of Harvard College
    Inventors: Edward M. Alderman, James W. Fett, Bert L. Vallee
  • Antibodies to angiogenin: immunotherapeutic agents
    Patent number: 4853219
    Abstract: This invention relates to the production of antibodies to angiogenin or to fragments thereof and to methods of inhibiting angiogenesis in mammals by administering to mammals such antibodies or Fab fragments thereof so as to inhibit angiogenic activity. In addition, this invention relates to pharmaceutical compositions comprising therapeutically effective amounts of antibody that are immunologically reactive with angiogenin and which can be administered to inhibit angiogenesis.
    Type: Grant
    Filed: August 6, 1987
    Date of Patent: August 1, 1989
    Assignee: President and Fellows of Harvard College
    Inventors: Edward M. Alderman, James W. Fett, Bert L. Vallee
  • Purified protein having angiogenic activity and methods of preparation
    Patent number: 4727137
    Abstract: A substantially pure protein having angiogenic activity is disclosed. A method for preparing proteins having angiogenic activity from cell culture media is also disclosed. Proteins produced according to the invention are useful in the diagnosis of malignancies, for promoting wound healing, and for other diagnostic and therapeutic purposes.
    Type: Grant
    Filed: September 20, 1985
    Date of Patent: February 23, 1988
    Assignee: President and Fellows of Harvard College
    Inventors: Bert L. Vallee, James W. Fett