Abstract: The invention describes a method for the isolation of components from samples, particularly large molecular weight DNA from biological samples. The method involves the application of controlled oscillatory mechanical energy to the sample for short periods of time of about 5 to 60 seconds to lyse the sample and release the component(s) from the sample, followed by standard isolation methods. In preferred embodiments, the method includes the use of a spherical particle for applying the mechanical energy.

Abstract: The invention describes a method for the isolation of components from samples, particularly large molecular weight DNA from biological samples. The method involves the application of controlled oscillatory mechanical energy to the sample for short periods of time of about 5 to 60 seconds to lyse the sample and release the component(s) from the sample, followed by standard isolation methods. In preferred embodiments, the method includes the use of a spherical particle for applying the mechanical energy.

Abstract: The invention describes a method for the isolation of components from samples, particularly large molecular weight DNA from biological samples. The method involves the application of controlled oscillatory mechanical energy to the sample for short periods of time of about 5 to 60 seconds to lyse the sample and release the component(s) from the sample, followed by standard isolation methods. In preferred embodiments, the method includes the use of a spherical particle for applying the mechanical energy.

Abstract: The invention describes a method for the isolation of components from samples, particularly large molecular weight DNA from biological samples. The method involves the application of controlled oscillatory mechanical energy to the sample for short periods of time of about 5 to 60 seconds to lyse the sample and release the component(s) from the sample, followed by standard isolation methods. In preferred embodiments, the method includes the use of a spherical particle for applying the mechanical energy.

Abstract: An improved apparatus and method for nucleic acid base sequencing by annealing a primer to a nucleic acid template, extending the primer and direct step-wise detecting of incorporated bases, without the use of nucleic acid fragments, extrinsic labeling or electrophoresis, the apparatus described by employing a simple rotary valve system to generate sequential growth of a molecular chain, a laser beam and detection system for determining the amount of native fluorescence quenched in an aliquot of reaction mixture solution as each nucleotide species is extracted from a reactant solution and incorporated into the growing chain.

Abstract: In a plastic "miniprep" device for separating liquid samples including (i) a first, sample, cylindrical container having an inlet and an outlet opening between which a separation layer is arranged, the outlet opening typically being connected to and enclosed by an outlet spout, fitting within a cylindrical bore of (ii) a second, collecting, container receiving the separated liquid discharged from the outlet spout, the cylindrical first container is (a) of lesser diameter than is the bore, and (b) possessed of longitudinal exterior rib hat hold it eccentric within the bore. According to the (a) lessor diameter and (b) eccentric mounting, access may be had by hypodermic syringe or thin pipette down the side of the first container to separated liquid present at the bottom of the second container.

Abstract: The present invention contemplates a system and formulations for preparing cell culture medium useful for growing cells for the purpose of producing and isolating nucleic acids. Dry-concentrate culture medium compositions are described as packaged in unit dose form such as in dissolvable capsules.

Abstract: A spacer-comb element including (i) a longitudinal central axis and (ii) three or more, preferably four, teeth arrays radially extending about the central axis and extending along a length thereof, serves to emplace arrayed slit apertures within flat sheets of a gel state material that is itself suitable to receive samples upon which electrophoresis may be performed. The spacer-comb element is placed between the sidewalls of, and engaged by, a tray holding the gel material in a central reservoir so that the teeth of only a selected one array extend downwards into the tray. An opposite, upwards-extending, teeth array engages the underside of an overlying tray, preferably at an optional complimentary groove feature on the tray's underside, so as to support the tray.