Patents by Inventor James W. Hodges
James W. Hodges has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220040160Abstract: A method of reducing cancer cell growth, a method of increasing sensitivity of cancer cells to CTL mediated killing, and a method of increasing sensitivity of cancer cells to NK mediated killing are provided. The methods comprise treating cancer cells with a combination of a HDAC inhibitor and immunotherapy.Type: ApplicationFiled: August 16, 2021Publication date: February 10, 2022Applicant: The United States of America,as represented by the Secretary,Department of Health and Human ServicesInventors: James W. Hodge, Sofia R. Gameiro
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Publication number: 20200140567Abstract: The invention is directed to methods of reducing growth of prostate cancer cells and breast cancer cells, which comprises treating such cancer cells with a combination of androgen or endocrine deprivation therapy (e.g., enzalutamide, abiraterone, and tamoxifen) and immunotherapy.Type: ApplicationFiled: November 18, 2019Publication date: May 7, 2020Applicant: The United States of America,as represented by the Secretary,Department of Health and Human ServicesInventors: Jeffrey Schlom, James W. Hodge
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Publication number: 20190183870Abstract: A method of reducing cancer cell growth, a method of increasing sensitivity of cancer cells to CTL mediated killing, and a method of increasing sensitivity of cancer cells to NK mediated killing are provided. The methods comprise treating cancer cells with a combination of a HDAC inhibitor and immunotherapy.Type: ApplicationFiled: January 4, 2017Publication date: June 20, 2019Applicant: The United States of America, as represented by the Secretary, Dept. of Health and Human ServicesInventors: James W. Hodge, Sofia R. Gameiro
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Publication number: 20170306042Abstract: The invention is directed to methods of reducing growth of prostate cancer cells and breast cancer cells, which comprises treating such cancer cells with a combination of androgen or endocrine deprivation therapy (e.g., enzalutamide, abiraterone, and tamoxifen) and immunotherapy.Type: ApplicationFiled: August 28, 2015Publication date: October 26, 2017Applicant: The United States of America, as represented by the Secretary, Department of Health and Human ServInventors: Jeffrey Schlom, James W. Hodge
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Patent number: 9494236Abstract: A gasket is provided with two dissimilar materials. The two different materials are used to provide different sealing characteristics. In one embodiment, the different sealing materials join to create the same or a similar profile to the profile of the individual materials. In another embodiment, the different sealing materials have the same profile but have joining portions that are complementary to one another where the two materials are joined to one another.Type: GrantFiled: November 6, 2014Date of Patent: November 15, 2016Assignee: Dana Automotive Systems Group, LLCInventors: Christopher M. Cook, Kelly D. Puckett, Dakota W. Foster, Jason D. Wimberley, Justin R. Knott, James W. Hodges
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Publication number: 20160131258Abstract: A gasket is provided with two dissimilar materials. The two different materials are used to provide different sealing characteristics. In one embodiment, the different sealing materials join to create the same or a similar profile to the profile of the individual materials.Type: ApplicationFiled: November 6, 2014Publication date: May 12, 2016Inventors: Christopher M. Cook, Kelly D. Puckett, Dakota W. Foster, Jason D. Wimberley, Justin R. Knott, James W. Hodges
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Patent number: 8933041Abstract: The present invention is directed to a system for treating individuals at risk of or suffering from breast cancer. The system comprises administering to the individual a recombinant poxvirus, where the poxvirus contains in a foreign nucleic acid encoding at least one breast cancer antigen.Type: GrantFiled: November 12, 2004Date of Patent: January 13, 2015Assignee: The United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Dennis L. Panicali, Gail P. Mazzara, Linda R. Gritz, Jeffrey Schlom, Kwong-Yok Tsang, James W. Hodge
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Patent number: 8901093Abstract: The present invention is directed to a system for treating individuals at risk of developing or suffering from pancreatic cancer. The system comprises administering to the individual a recombinant poxvirus, where the poxvirus contains a foreign nucleic acid encoding at least one pancreatic tumor associated antigen (PTAA).Type: GrantFiled: November 12, 2004Date of Patent: December 2, 2014Assignee: The United States of America, as represented by the Secretary of the Department of Health and Human ServicesInventors: Dennis L. Panicali, Gail P. Mazzara, Linda R. Gritz, Jeffrey Schlom, Kwong-Yok Tsang, James W. Hodge
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Patent number: 7662395Abstract: The present invention is a composition of recombinant virus which has incorporated into its genome or portion thereof a gene encoding an antigen to a disease causing agent and a recombinant virus which has incorporated into its genome or portion thereof a gene encoding an immunostimulatory molecule(s) for the purpose of stimulating an immune response against the disease causing agent. Methods of treatment of diseases such as cancer and diseases caused by pathogenic microorganisms is provide using the composition.Type: GrantFiled: April 30, 2008Date of Patent: February 16, 2010Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Jeffrey Schlom, Judith Kantor, James W. Hodge
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Publication number: 20080279887Abstract: The present invention is a composition of recombinant virus which has incorporated into its genome or portion thereof a gene encoding an antigen to a disease causing agent and a recombinant virus which has incorporated into its genome or portion thereof a gene encoding an immunostimulatory molecule(s) for the purpose of stimulating an immune response against the disease causing agent. Methods of treatment of diseases such as cancer and diseases caused by pathogenic microorganisms is provide using the composition.Type: ApplicationFiled: April 30, 2008Publication date: November 13, 2008Applicant: The Government of the United States of America, as Represented by the Secretary, Department of HealtInventors: Jeffrey Schlom, Judith Kantor, James W. Hodge
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Publication number: 20080166367Abstract: The present invention is directed to a system for treating individuals at risk of developing or suffering from pancreatic cancer. The system comprises administering to the individual a recombinant poxvirus, where the poxvirus contains a foreign nucleic acid encoding at least one pancreatic tumor associated antigen (PTAA).Type: ApplicationFiled: November 12, 2004Publication date: July 10, 2008Inventors: Dennis L. Panicali, Gail P. Mazzara, Linda R. Gritz, Jeffrey Schlom, Kwong-Yok Tsang, James W. Hodge
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Patent number: 7368116Abstract: The present invention is a composition of recombinant virus which has incorporated into its genome or portion thereof a gene encoding an antigen to a disease causing agent and a recombinant virus which has incorporated into its genome or portion thereof a gene encoding an immunostimulatory molecule(s) for the purpose of stimulating an immune response against the disease causing agent. Methods of treatment of diseases such as cancer and diseases caused by pathogenic microorganisms is provide using the composition.Type: GrantFiled: March 28, 2005Date of Patent: May 6, 2008Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Jeffrey Schlom, Judith Kantor, James W. Hodge
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Patent number: 6893869Abstract: The present invention is a composition of recombinant virus which has incorporated into its genome or portion thereof a gene encoding an antigen to a disease causing agent and a recombinant virus which has incorporated into its genome or portion thereof a gene encoding an immunostimulatory molecule(s) for the purpose of stimulating an immune response against the disease causing agent. Methods of treatment of diseases such as cancer and diseases caused by pathogenic microorganisms is provide using the composition.Type: GrantFiled: January 14, 2003Date of Patent: May 17, 2005Assignee: The United States of America as represented by the Secretary of the Department of Health and Human ServicesInventors: Jeffrey Schlom, Judith Kantor, James W. Hodge
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Patent number: 6548068Abstract: The present invention is a composition of recombinant virus which has incorporated into its genome or portion thereof a gene encoding an antigen to a disease causing agent and a recombinant virus which has incorporated into its genome or portion thereof a gene encoding an immunostimulatory molecule(s) for the purpose of stimulating an immune response against the disease causing agent. Methods of treatment of diseases such as cancer and diseases caused by pathogenic microorganisms is provide using the composition.Type: GrantFiled: January 7, 2000Date of Patent: April 15, 2003Assignee: The United States of America as represented by the Secretary of the Department of Health and Human ServicesInventors: Jeffrey Schlom, Judith Kantor, James W. Hodge
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Patent number: 6045802Abstract: The present invention is a composition of recombinant virus which has incorporated into its genome or portion thereof a gene encoding an antigen to a disease causing agent and a recombinant virus which has incorporated into its genome or portion thereof a gene encoding an immunostimulatory molecule(s) for the purpose of stimulating an immune response against the disease causing agent. Methods of treatment of diseases such as cancer and diseases caused by pathogenic microorganisms is provide using the composition.Type: GrantFiled: June 7, 1995Date of Patent: April 4, 2000Assignee: The United States of America as represented by the Secretary of the Department Of Health and Human ServicesInventors: Jeffrey Schlom, Judith Kantor, James W. Hodge
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Patent number: 5417272Abstract: A pivotal and extendable bathing door unit is disclosed wherein a first panel is pivotally connected to a supporting wall, and a second panel is extendably connected to the first panel, so that the door can operate to enclose without an overhead track. There are roller tracks and rollers cross-linked to each other while permitting lateral relative movement therebetween. In one form, cam members are associated with the pivotal connection of the first panel to provide a lifting action between bistable positions, and a magnetic member is connected to a handle on the second panel for attraction to a similar second panel of a second similar door unit.Type: GrantFiled: July 2, 1993Date of Patent: May 23, 1995Assignee: Sterling Plumbing Group, Inc.Inventors: James L. Marlowe, Ronald M. Wise, Larry D. Bruce, James W. Hodges
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Patent number: 4453346Abstract: An adjustable wall jamb assembly for a shower door comprising a fixed wall jamb member adapted to be affixed to a wall, an adjustable block assembly comprising a block adapted to be affixed to the fixed wall jamb and having a threaded opening, and an adjustment screw having an external thread complementary with that of the adjustment block, the adjustment screw having an axial aperture and engaging means at one end for being engaged and rotated within the adjustment block, an adjustable jamb member adapted to slide over the fixed jamb member and to engage the end of the adjustment screw, and a screw disposed through an aperture in the adjustable jamb member, extending through the axial opening of the adjustable screw and being adapted to enter the wall on which the fixed jamb member is mounted.Type: GrantFiled: May 24, 1982Date of Patent: June 12, 1984Assignee: United States Gypsum CompanyInventors: David W. Powell, James W. Hodges