Abstract: An excisional device for either handheld or stereotactic table/MRI use may comprise a work element configured to rotate at a first rotation rate and comprising at least one articulable beak configured to cut tissue in a longitudinal direction. Helical elements or equivalent assemblies may be configured to transport tissue cut by a work element and may be co-axially disposed relative to the work element and may be operative to rotate at rotation rates that may be different from the work element rotation rate. Flush and vacuum tissue transport mechanisms may be incorporated in replacement of or in conjunction with helical elements. A proximal sheath and a distal sheath may be co-axially disposed relative to a work element and may be configured to rotate a work element and to actuate a beak or beaks. A simplified embodiment of this device may be applicable to field use where power sources for actuation may be limited.

Abstract: An excisional device for either handheld or stereotactic table/MRI use may comprise a work element configured to rotate at a first rotation rate and comprising at least one articulable beak configured to cut tissue in a longitudinal direction. Helical elements or equivalent assemblies may be configured to transport tissue cut by a work element and may be co-axially disposed relative to the work element and may be operative to rotate at rotation rates that may be different from the work element rotation rate. Flush and vacuum tissue transport mechanisms may be incorporated in replacement of or in conjunction with helical elements. A proximal sheath and a distal sheath may be co-axially disposed relative to a work element and may be configured to rotate a work element and to actuate a beak or beaks. A simplified embodiment of this device may be applicable to field use where power sources for actuation may be limited.

Abstract: A device comprises a syringe comprising a syringe body portion and a plunger portion configured to engage with and slide axially within the body portion; a tube set fitted to the syringe. The tube set may comprise a proximal tube attached to the plunger portion at a proximal end thereof and terminated, at a distal end thereof, by a beak assembly configured to assume a first configuration suitable for coring through tissue and a second configuration suitable for tissue penetration and parting off tissue; and a distal tube disposed over and coupled to the proximal tube to enable travel-limited axial displacement relative to the proximal tube. Axially moving the plunger portion of the plunger portion within the body portion of the syringe causes differential movement of the proximal tube relative to the distal tube to selectively cause the beak assembly to assume the first or the second configuration.

Abstract: A hybrid VTOL/high speed aircraft may comprise systems and functions for in flight configuration changes from high lift helicopter or VTOL mode to fixed or swing-wing high speed aircraft mode to accommodate a variety of functions or missions.

Abstract: A hybrid VTOL/high speed aircraft may comprise systems and functions for in flight configuration changes from high lift helicopter or VTOL mode to fixed or swing-wing high speed aircraft mode to accommodate a variety of functions or missions.

Abstract: An excisional biopsy and delivery device may comprise one or more rotating, penetrating and cutting rod elements. The rod elements may be configured to advance from a stored and confined first position and rotate about an axis, while being simultaneously revolved about a central axis. The rod elements may then assume a second released and expanded configuration that is operative to cut around and surround target tissue. In this manner, the rod elements are operative to move through the surrounding tissue to create a volume of revolution and to sever and capture the target tissue contained within the volume of revolution from the surrounding tissue. The severed and captured volume of revolution containing the target issue may then be removed.

Abstract: The present invention is directed to tissue removal devices and methods. A tubular element having an open distal end is advanced into tissue so that tissue enters the tubular element. The tissue, which entered the tubular element is cut to separate the tissue from the surrounding tissue. The tissue is then transported proximally by the cutting element or a separate transport element.

Abstract: Devices and methods for cutting and collecting a specimen from a mass of tissue. The device may include an integrated cut and collect assembly. The integrated cut and collect assembly includes a cutting portion and a collection portion that includes a flexible membrane. The collection portion of the assembly is attached to the cutting portion thereof. The cutting portion is configured to cut the specimen from the mass of tissue and the collection portion is configured to collect the cut specimen and to encapsulate and isolate the cut specimen within the membrane to enable its safe retraction from the mass of tissue.

Abstract: An excisional device for either handheld car stereotactic table use may comprise an outer sheath that may comprise a distal scoopula shape configured to penetrate and/or cut tissue independently or in concert with work element(s). The articulable work element(s) may comprise articulable beak(s) and may be configured to translate and/or rotate at a first rate and to cut tissue in a direction implied by placement of the scoopula shaped outer sheath. A first helical element or equivalent assembly may be configured to transport tissue cut by the work element(s) and/or scoopula, may be co-axially disposed relative to the work element(s) and may be operative to rotate at a second rotation rate that is different than the first rate. A proximal sheath may be co-axially disposed relative to the work element(s) and the first helical element, and may be configured to rotate and actuate the work element(s).

Abstract: A steerable, conformable, drug eluting balloon catheter device may comprise a catheter stem with one or more balloon element(s), themselves comprised of one or more segment(s) arranged radially or axially along the length of the device, and may allow precise deployment of vascular interventional devices, including coring devices and/or placement of stents, and may also allow targeted, specific placement of selected diagnostic or therapeutic materials on the walls of a vascular structure during a cardiovascular intervention procedure.

Abstract: A soft tissue biopsy or material collection device may comprise a work element consisting of an outer tube with external sheath and formed from a tapered helical structure over an internal tube structure configured to open and close its distal end to perform penetration, coring, capturing, parting off and transporting multiple material samples in a single or multiple insertion procedure.

Abstract: A device comprises a syringe comprising a syringe body portion and a plunger portion configured to engage with and slide axially within the body portion; a tube set fitted to the syringe. The tube set may comprise a proximal tube attached to the plunger portion at a proximal end thereof and terminated, at a distal end thereof, by a beak assembly configured to assume a first configuration suitable for coring through tissue and a second configuration suitable for tissue penetration and parting off tissue; and a distal tube disposed over and coupled to the proximal tube to enable travel-limited axial displacement relative to the proximal tube. Axially moving the plunger portion of the plunger portion within the body portion of the syringe causes differential movement of the proximal tube relative to the distal tube to selectively cause the beak assembly to assume the first or the second configuration.

Abstract: A vertical takeoff and landing craft that utilizes lifting, propulsion and maneuvering (LPM) assemblies comprising a series of blade foils arranged along track elongated loop paths disposed at the sides of a fuselage. These LPM assemblies are provided with control mechanisms enabling lift, attitude changes, altitude changes and directional flight propulsion and control including those needed for hovering as well as vertical takeoff and landing. The LPM assemblies are configured to drive large volumes of air in a manner and scale favorably similar to conventional rotorcraft while in contrast, providing capability for faster flights by eliminating or minimizing speed limiting factors commonly associated with rotorcraft.

Abstract: A vascular interventional device may comprise a combination of inflatable and cutting elements and embodiments may comprise structures and functionality for dilatation of blood vessels narrowed by diseases, removal of plaque and debris from diseased blood vessels and delivery of drugs for the prevention of re-narrowing of vessel luminal cross-section area as well as to provide scaffolding when needed to keep vessels patent.

Abstract: A needle is used to mark a tissue area of interest. The needle may have one or more indicators which indicate selected angular orientations relative to the needle. The indicators may also be coupled to anchors which are deployed in the tissue to anchor the needle in the tissue. The needle may be positioned to guide an excisional device to remove tissue.

Abstract: A vertical takeoff and landing craft that utilizes lifting, propulsion and maneuvering (LPM) assemblies comprising a series of blade foils arranged along track elongated loop paths disposed at the sides of a fuselage. These LPM assemblies are provided with control mechanisms enabling lift, attitude changes, altitude changes and directional flight propulsion and control including those needed for hovering as well as vertical takeoff and landing. The LPM assemblies are configured to drive large volumes of air in a manner and scale favorably similar to conventional rotorcraft while in contrast, providing capability for faster flights by eliminating or minimizing speed limiting factors commonly associated with rotorcraft.

Abstract: A hybrid VTOL/high speed aircraft may comprise systems and functions for in flight configuration changes from high lift helicopter or VTOL mode to fixed or swing-wing high speed aircraft mode to accommodate a variety of functions or missions.

Abstract: An excisional device may comprise a work element configured to rotate at a first rotation rate and comprising a first and a second articulable beak configured to cut tissue. A first helical element, configured to transport tissue cut by the first and second articulable beaks, may be co-axially disposed relative to the work element and operative to rotate at a second rotation rate that is different than the work element. A proximal sheath may be co-axially disposed relative to the work element and the first helical element, and may be configured to rotate the work element and to actuate the first and second articulable beaks.

Abstract: A device for intra-vascular embolic-thrombolic protection, as well as embolectomy/thrombectomy and atherectomy interventional procedures and methods. At least a portion of the working end of the device may be formed monolithically from a single hypodermic tube, or may be formed of monolithic inner and outer tubes with fixed or movable guide wire elements and imaging modalities. The device may comprise structures enabling coring, expansion within a vascular structure and vascular wall shaving, as well as filtration, stabilization and capturing of thrombotic or embolitic material during an intervention procedure.

Abstract: An excisional device for either handheld or stereotactic table use may comprise an outer sheath that may comprise a distal trough shape configured to penetrate and/or cut tissue independently or in concert with work element(s). The articulable work element(s) may comprise articulable beak(s) and may be configured to translate and/or rotate at a first rate and to cut tissue in a direction implied by placement of the trough shaped outer sheath. A first helical element or equivalent assembly may be configured to transport tissue cut by the work element(s) and/or trough, may be co-axially disposed relative to the work element(s) and may be operative to rotate at a second rotation rate that is different than the first rate. A proximal sheath may be co-axially disposed relative to the work element(s) and the first helical element, and may be configured to rotate and actuate the work element(s).