Patents by Inventor James W. Zapf

James W. Zapf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for Identifying Risk of Type II Diabetes and Treatments Thereof
    Publication number: 20080199480
    Abstract: Provided herein are methods for identifying a risk of type II diabetes in a subject, reagents and kits for carrying out the methods, methods for identifying candidate therapeutics for treating type II diabetes, and therapeutic and preventative methods applicable to type II diabetes. These embodiments are based upon an analysis of polymorphic variations in nucleotide sequences within the human genome.
    Type: Application
    Filed: July 22, 2004
    Publication date: August 21, 2008
    Applicant: SEQUENOM, INC.
    Inventors: Maria L. Langdown, Matthew R. Nelson, Rikard H. Reneland, Stefan M. Kammerer, Andreas Braun, Mikhail F. Denissenko, Josephine M. Atienza, Eddine Saiah, James W. Zapf
  • Bicyclic heterocycles for the treatment of diabetes and other diseases
    Patent number: 7196108
    Abstract: The invention relates to certain bicyclic heterocycles havng the structure shown below which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes, and atherosclerosis.
    Type: Grant
    Filed: March 6, 2003
    Date of Patent: March 27, 2007
    Assignees: Incyte San Diego Inc., Ortho McNeil Pharmaceutical Inc.
    Inventors: Magnus Pfahl, Catherine Tachdjian, Hussien A. Al-Shamma, Andrea Fanjul Giachino, Karine Jakubowicz-Jaillardon, Jianhua Guo, Richard M. Fine, Lyle W. Spruce, James W. Zapf
  • Heterocyclic amide derivatives for the treatment of diabetes and other diseases
    Patent number: 7102000
    Abstract: The present invention relates to certain substituted heterocycles of Formula (200), wherein B, H, I, J and K together with the Ar5 form a ring containing at least one amide residue, and W, X, Y and Z together form a 2,4-thiazolidinedione, 2-thioxo-thiazolidine-4-one, 2,4-imidazolidinedione or 2-thioxo-imidazolidine-4-one residue; or a pharmaceutically acceptable salt thereof. The compounds are useful in the treatment of diseases such as type 2 diabetes, and related disorders of lipid and carbohydrate metabolism, including atherosclerosis. The compounds are also useful for treating diseases of uncontrolled proliferation, such as cancers in general, including breast cancer.
    Type: Grant
    Filed: March 6, 2003
    Date of Patent: September 5, 2006
    Assignees: Incyte San Diego Inc., Ortho McNeil Pharmaceutical Inc.
    Inventors: Magnus Pfahl, Catherine Tachdjian, Hussien A. Al-Shamma, Andrea Fanjul Giachino, Karine Jakubowicz-Jaillardon, Jianhua Guo, Mohamed Boudjelal, James W. Zapf
  • 2-Substituted thiazolidinone and oxazolidinone derivatives for the inhibition of phosphatases and the treatment of cancer
    Publication number: 20040097566
    Abstract: The present invention relates to certain substituted heterocycles, including 2-substituted thiazolidinone and 2-substituted oxazolidinone compounds. These compounds are useful in the treatment of diseases related to uncontrolled cellular proliferation, such as cancer or precancerous conditions. The compounds are also useful for modulating lipid and/or carbohydrate metabolism, and treating Type II diabetes, hyperglycemia or obesity, and for treating inflammatory diseases such as arthritis.
    Type: Application
    Filed: December 6, 2002
    Publication date: May 20, 2004
    Inventors: Magnus Pfahl, Hussien A. Al-Shamma, Andrea Fanjul Giachino, David P. M. Pleynet, Haifeng Bao, Lyle W. Spruce, Christopher N. Cow, Catherine Tachdjian, James W. Zapf, Torsten R. Wiemann
  • Bicyclic heterocycles for the treatment of diabetes and other diseases
    Publication number: 20040034004
    Abstract: The invention relates to certain bicyclic heterocycles havng the structure shown below which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes, and atherosclerosis.
    Type: Application
    Filed: March 6, 2003
    Publication date: February 19, 2004
    Inventors: Magnus Pfahl, Catherine Tachdjian, Hussien A. Al-Shamma, Andrea Fanjul Giachino, Karine Jakubowicz-Jaillardon, Jianhua Guo, Richard M. Fine, Lyle W. Spruce, James W. Zapf
  • Heterocyclic amide derivatives for the treatment of diabetes and other diseases
    Publication number: 20030216432
    Abstract: The present invention relates to certain substituted heterocycles of Formula (200), 1
    Type: Application
    Filed: March 6, 2003
    Publication date: November 20, 2003
    Inventors: Magnus Pfahl, Catherine Tachdjian, Hussien A. Al-Shamma, Andrea Fanjul Giachino, Karine Jakubowicz-Jaillardon, Jianhua Guo, Mohamed Boudejelal, James W. Zapf
  • RXR activating molecules
    Publication number: 20030105333
    Abstract: Disclosed are molecules that activate an RXR receptor, wherein the molecule comprises an RXR binding portion which binds the RXR receptor and comprises a side pocket contacting residue which contacts a side-pocket 1 of an RXR receptor.
    Type: Application
    Filed: March 8, 2002
    Publication date: June 5, 2003
    Inventors: Magnus Pfahl, Catherine Tachdjian, Hussien A. Al-Shamma, Andrea N. Fanjul, David P.M. Pleynet, Lyle W. Spruce, Richard Fine, James W. Zapf, Jianhua Guo, Karine Jakubowicz-Jaillardon