Abstract: An implantable medical device includes an expandable frame that is expandable between a collapsed configuration for delivery and an expanded configuration for deployment, the expandable frame including a periphery defined by the expandable frame. A covering spans at least part of the expandable frame. An expandable element is secured relative to the periphery, the expandable element is adapted to seal against an irregular body opening such as an irregular-shaped ostium of a patient's LAA (left atrial appendage).

Abstract: A system and method for distinguishing targets of interest from main lobe clutter and sidelobe clutter includes an ESA or AESA divided into subarrays. A sum beam power profile is produced via one or more scans of the subarrays, and a difference beam power profile is produced via calculations involving the subarrays. A comparison of the sum beam power profile and the difference beam power profile accentuates signal power disparities between targets of interest and clutter. A threshold is then applied to isolate targets of interest. Different difference beam power profiles may be used for elevation comparisons and azimuth comparisons. Alternatively, subarrays may be selected such that the same difference beam power profile may be used for both elevation and azimuth. Scans may be time multiplexed such that data from different scans may be used to produce the sum beam power profile, the difference beam power profile, or both.

Abstract: A fibrous structure. The structure may include a plurality of continuous or semi-continuous knuckles extending from portions of the surface of the fibrous structure in a parallel path, wherein the plurality of knuckles may be separated by adjacent continuous or semi-continuous pillows. Each knuckle may comprise a plurality of discrete pillows, the plurality of discrete pillows may be arranged in a spaced configuration along the path of each knuckle; alternatively, each pillow may comprise a plurality of discrete knuckles, the plurality of discrete knuckles may be arranged in a spaced configuration along the path of each pillow.

Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of plant species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.

Abstract: A traction battery assembly according to an exemplary aspect of the present disclosure includes, among other things, a tray, at least one battery module, a lid secured to the tray to provide an enclosure having an interior that houses the at least one battery module, the lid having a lid aperture, and a reinforcement member is secured directly to the lid. The reinforcement member has a reinforcement member aperture. A fastener extends through the lid aperture and the reinforcement member aperture. The fastener is secured to a structure within the interior. The reinforcement member is secured directly to the lid separately from the fastener.

Abstract: An aqueous dispersion of multistage polymer particles comprising a specific oligomer prepared from polymerization of monomers comprising an alkoxylated (meth)acrylate providing aqueous coating compositions with both good flow-and-leveling property and extended open time.

Abstract: The disclosure describes embodiments of systems, methods, and non-transitory computer readable storage media that utilize a machine learning model and a credit value model to generate user interface elements that present credit values and credit value conditions in real time for user accounts. For instance, the disclosed systems can generate an activity score using an activity machine learning model with internal user activity data of a user account. Then, utilizing a credit value model with the activity score and a user activity condition, the disclosed systems can determine a dynamic credit value range for the user account. Indeed, the disclosed systems can display user interface elements with selectable credit values from the dynamic credit value range. Additionally, the disclosed systems can utilize the credit value model to determine and display one or more dynamic credit value conditions for a selected credit value received from the selectable credit values.

Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: This disclosure describes methods, non-transitory computer readable media, and systems that can use a computationally efficient model to determine a corrected methylation-level value for a specific sample nucleotide sequence. For instance, the disclosed systems determine a false positive rate and a false negative rate at which a given methylation sequencing assay converts cytosine bases. Based on the determined false positive rate and false negative rate, the disclosed systems determine a corrected methylation-level value that corrects for a bias of the given methylation sequencing assay.

Abstract: The present disclosure relates to reduced sugar content milk chocolate confection and confectionery products comprising at least one rare sugar, such as allulose, methods of making the same wherein the confections and confectionery products have desirable rheological properties and organoleptic properties and stable viscosity over time. The present disclosure also relates to preventing thickening of reduced sugar content milk chocolate confections comprising at least one rare sugar, such as allulose, during manufacturing, and maintaining stable viscosity over time.

Abstract: The invention provides DNA compositions that relate to transgenic insect resistant maize plants. Also provided are assays for detecting the presence of the maize DAS-59122-7 event based on the DNA sequence of the recombinant construct inserted into the maize genome and the DNA sequences flanking the insertion site. Kits and conditions useful in conducting the assays are provided.

Abstract: A sensor component includes a sensor including a sensor surface and a reaction site in cooperation with the sensor and exposing the sensor surface. The reaction site including a reaction site surface. A surface agent is bound to the reaction site surface or the sensor surface. The surface agent includes a surface active functional group reactive with Bronsted base or Lewis acid functionality on the reaction site surface or the sensor surface and including distal functionality that does not have a donor electron pair.

Abstract: A method includes obtaining, at a first data provider, a first query generation request. The method also includes determining whether a first query, that is to be generated based on the first query generation request, is approved. In response to a determination that the first query, that is to be generated, is approved, the method also includes generating the first query. The method further includes sharing the generated first query with a second data provider.

Abstract: Systems and methods are described for merging customer profiles, such as may be implemented by a computer-implemented contact center service. In some aspects, a subset of profiles may be determined that satisfy merging criteria, where individual profiles include a plurality of data fields. At least one value in a first data field that conflicts between at least two profiles may be identified. Next a merged value may be selected for the first data field based on data deduplication criteria, where the data deduplication criteria includes at least one indicator of accuracy of values of the plurality of data fields. As a result of a determination that at least the subset of profiles of the group of profiles meet the merging criteria, at least the subset of profiles may be combined into a combined profile using the merged value.

Abstract: An implantable medical device such as but not limited to a left atrial appendage closure (LAAC) device includes an expandable frame that is movable between a collapsed configuration for delivery and an expanded configuration for deployment. The expandable frame may include a plurality of articulating members that are biased into the expanded configuration. The expandable frame may include a biasing member. The LAAC device includes a membrane or covering that spans across an end of the expandable frame.

Abstract: A recombinant adeno-associated virus (rAAV) vector comprising an AAVhu68 capsid produced in a production system comprising a nucleotide sequence of SEQ ID NO: 1, or a sequence at least 75% identical thereto which encodes SEQ ID NO:2. The AAVhu68 capsid comprises subpopulations of highly deamidated asparagine residues in asparagine-glycine pairs in the amino acid sequence of SEQ ID NO: 2. Also provided are compositions containing the rAAV and uses thereof. Additionally, rAAV having an engineered AAV capsid comprising at least one subpopulation of vp1 or vp2 proteins having a Val at amino acid position 157 with reference to the AAVhu68 vp1 numbering are provided.

Abstract: Systems and methods are provided for use in assessing disease threat in a field. An example computer-implemented method includes accessing weather data for a field where the field includes a crop and the weather data includes a weather condition for the field during a time period and identifying multiple intervals within the time period as threat intervals, based on the weather condition of the field during each of the multiple intervals being with a first range. The method also includes aggregating the multiple threat intervals into a damaging factor, based, in part, on ones of the multiple intervals being consecutive intervals during the time period, and comparing the damaging factor to a threat threshold. The method then includes, in response to the damaging factor satisfying the threat threshold, generating and transmitting, by the computing device, an output indicative of the damaging factor.

Abstract: The present invention relates to methods that employ enzymes having Asx-specific ligase and cyclase activity, namely butelase-1, VyPAL2 and OaAEPI b, as a means for engineering novel (poly) peptide theranostics. The differential substrate specificities and differential optimal pH of the Asx-specific ligase and cyclase are used to provide sufficient orthogonality for a tandem ligation and cyclization of proteins. Also encompassed are the corresponding uses.

Abstract: The present disclosure relates to HIF-2? inhibitors and methods of making and using them for treating cancer. Certain compounds were potent in HIF-2? scintillation proximity assay, luciferase assay, and VEGF ELISA assay, and led to tumor size reduction and regression in 786-O xenograft bearing mice in vivo.