Patents by Inventor Jan Aart Van Mourik

Jan Aart Van Mourik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Factor VIII polypeptide having factor VIII:C activity
    Patent number: 8546332
    Abstract: Factor VIII polypeptides having FVIII:C activity that contain modifications in the A3 and/or C1 and/or C2 domains of the sequence of the light chain of Factor VIII, characterized by the binding affinity to low density lipoprotein receptor protein, and methods for producing the same.
    Type: Grant
    Filed: February 19, 2009
    Date of Patent: October 1, 2013
    Assignee: Stichting Sanquin Bloedvoorziening
    Inventors: Petrus Johannes Lenting, Jan Aart Van Mourik, Koenraad Mertens, Hans Pannekoek, Peter Turecek, Hans-Peter Schwarz, Friedrich Scheiflinger
  • FACTOR VIII POLYPEPTIDE HAVING FACTOR VIII:C ACTIVITY
    Publication number: 20110118188
    Abstract: Factor VIII polypeptides having FVIII:C activity that contain modifications in the A3 and/or C1 and/or C2 domains of the sequence of the light chain of Factor VIII, characterized by the binding affinity to low density lipoprotein receptor protein, and methods for producing the same.
    Type: Application
    Filed: February 19, 2009
    Publication date: May 19, 2011
    Applicant: STICHTING SANQUIN BLOEDVOORZIENING
    Inventors: PETRUS JOHANNES LENTING, JAN AART VAN MOURIK, KOENRAAD MERTENS, HANS PANNEKOEK, PETER TURECEK, HANS-PETER SCHWARZ, FRIEDRICH SCHEIFLINGER
  • Factor VIII polypeptide having factor VIII:C activity
    Patent number: 7544660
    Abstract: Factor VIII polypeptides having FVIII:C activity that contain modifications in the A3 and/or C1 and/or C2 domains of the sequence of the light chain of Factor VIII, characterized by the binding affinity to low density lipoprotein receptor protein, and methods for producing the same.
    Type: Grant
    Filed: November 12, 2004
    Date of Patent: June 9, 2009
    Assignee: Stichting Sanquin Bloedvoorziening
    Inventors: Petrus Johannes Lenting, Jan Aart Van Mourik, Koenraad Mertens, Hans Pannekoek, Peter Turecek, Hans-Peter Schwarz, Friedrich Scheiflinger
  • Factor VII polypeptide having factor VII:C activity
    Patent number: 6919311
    Abstract: Factor VIII polypeptides having FVIII:C activity that contain modifications in the A3 and/or C1 and/or C2 domains of the sequence of the light chain of Factor VIII, characterized by the binding affinity to low density lipoprotein receptor protein, and methods for producing the same.
    Type: Grant
    Filed: May 10, 2001
    Date of Patent: July 19, 2005
    Assignee: Stichting Sanquin Bloedvoorziening
    Inventors: Petrus Johannes Lenting, Jan Aart Van Mourik, Koenraad Mertens, Hans Pannekoek, Peter Turecek, Hans-Peter Schwarz, Friedrich Scheiflinger
  • Method and means for detecting and treating disorders in the blood coagulation cascade
    Patent number: 6083905
    Abstract: This invention relates to the diagnosis of congenital defects in the anticoagulant protein C system. Methods that are disclosed are based on the detection of mutations at the cleavage sites of coagulation factors that are under control of activated protein C (APC). Diagnostic tests include analysis of the APC-cleavage sites of factor V and factor VIII, by using specific primers to amplify selectively from RNA, cDNA derived from RNA or chromosomal DNA, parts of factor V and factor VIII that contain cleavage sites for APC. Methods that monitor the presence of mutations at the cleavage sites for APC and their utility in the diagnosis of thrombo-embolic disease are disclosed. The invention further discloses methods for correcting the defects detected according to the invention, as well as novel therapeutic agents which can be used in the treatment of bleeding disorders, which agents are based on the "defective" Factor V and Factor VIII proteins leading to the thrombotic disorders described hereinabove.
    Type: Grant
    Filed: January 22, 1997
    Date of Patent: July 4, 2000
    Assignee: Stichting Sanquin Bloedvoorziening
    Inventors: Johannes Jacobus Voorberg, Jan Aart van Mourik, Koenraad Mertens
  • Antibodies specific for a haemostatic protein their use for isolating protein, haemostatic compositions devoid of proteolytic cleavage products of the protein
    Patent number: 5932706
    Abstract: A method for the generation of Ca++ independent antibodies against blood coagulation factors is described wherein an antibody selection strategy based upon small peptides comprising target sequences for limited proteolysis is employed. These antibodies which distinguish between intact and cleaved species of haemostatic protein provide novel tools for the isolation of intact haemostatic proteins.
    Type: Grant
    Filed: February 10, 1997
    Date of Patent: August 3, 1999
    Assignee: Stichting Centraal Laboratorium Van De Bloedtransfusiedienst Van Het Nederlandse Rode Kruis
    Inventors: Koenraad Mertens, Jan Aart van Mourik
  • Antibodies specific for a haemostatic protein, their use for isolating protein, haemostatic compositions devoid of proteolytic cleavage products of the protein
    Patent number: RE38202
    Abstract: A method for the generation of Ca++ independent antibodies against blood coagulation factors is described wherein an antibody selection strategy based upon small peptides comprising target sequences for limited proteolysis is employed. These antibodies which distinguish between intact and cleaved species of haemostatic protein provide novel tools for the isolation of intact haemostatic proteins.
    Type: Grant
    Filed: July 17, 2000
    Date of Patent: July 22, 2003
    Assignee: Stichting Sanquin Bloedvoorziening
    Inventors: Koenraad Mertens, Jan Aart van Mourik