Patents by Inventor Jan Alsner

Jan Alsner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for determining clinically relevant hypoxia in cancer
    Patent number: 10385399
    Abstract: The present invention provides a method for determining the oxygen status of a cancer of an individual. The method comprise determining the transcriptional expression level of ADM (SEQ ID No:1), and/or at least one gene selected from ANKRD37 (SEQ ID NO.: 3), P4HA2 (SEQ ID NO.: 12), NDRG1 (SEQ ID NO: 10), SLC2A1 (SEQ ID NO:15), P4HA1 (SEQ ID NO.: 11), LOX (SEQ ID NO.: 9), C3orf28 (SEQ ID NO.: 6), BNIP3L (SEQ ID NO.: 5), BNIP3 (SEQ ID NO.:4), EGLN3 (SEQ ID NO.: 7), PDK1 (SEQ ID NO.: 13), PFKFB3 (SEQ ID NO.: 14), KCTD11 (SEQ ID NO.: 8), and/or ALDOA (SEQ ID NO.: 2), in a cancer sample. The transcriptional level is then correlated to the transcriptional level to at least one reference gene, and oxygen status 10 is then evaluated by comparing the correlated transcription level with a predetermined reference sample comprising cancer cells characterized by a high oxygen level.
    Type: Grant
    Filed: April 30, 2012
    Date of Patent: August 20, 2019
    Assignee: AARHUS UNIVERSITET
    Inventors: Jens Overgaard, Brita Singers Sorensen, Jan Alsner, Carsten Wiuf, Marianne Nordsmark, Kasper Toustrup
  • METHOD FOR DETERMINING CLINICALLY RELEVANT HYPOXIA IN CANCER
    Publication number: 20150159218
    Abstract: The present invention provides a method for determining the oxygen status of a cancer of an individual. The method comprise determining the transcriptional expression level of ADM (SEQ ID No:1), and/or at least one gene selected from ANKRD37 (SEQ ID NO.: 3), P4HA2 (SEQ ID NO.: 12), NDRG1 (SEQ ID NO: 10), SLC2A1 (SEQ ID NO:15), P4HA1 (SEQ ID NO.: 11), LOX (SEQ ID NO.: 9), C3orf28 (SEQ ID NO.: 6), BNIP3L (SEQ ID NO.: 5), BNIP3 (SEQ ID NO.:4), EGLN3 (SEQ ID NO.: 7), PDK1 (SEQ ID NO.: 13), PFKFB3 (SEQ ID NO.: 14), KCTD11 (SEQ ID NO.: 8), and/or ALDOA (SEQ ID NO.: 2), in a cancer sample. The transcriptional level is then correlated to the transcriptional level to at least one reference gene, and oxygen status 10 is then evaluated by comparing the correlated transcription level with a predetermined reference sample comprising cancer cells characterized by a high oxygen level.
    Type: Application
    Filed: April 30, 2012
    Publication date: June 11, 2015
    Inventors: Jens Overgaard, Brita Singers Sorensen, Jan Alsner, Carsten Wiuf, Marianne Nordsmark, Kasper Toustrup
  • GENE SIGNATURES ASSOCIATED WITH EFFICACY OF POSTMASTECTOMY RADIOTHERAPY IN BREAST CANCER
    Publication number: 20150111758
    Abstract: The present invention relates to compositions, kits, and methods for providing a prognosis and/or determining a treatment course of action in a subject diagnosed with breast cancer. In particular, the present invention relates to gene expression signatures useful in the prognosis, diagnosis, and treatment of breast cancer.
    Type: Application
    Filed: March 6, 2013
    Publication date: April 23, 2015
    Inventors: Therese Sorlie, Arnoldo Frigessi, Anne-Lise Borresen-Dale, Simen Myhre, Hayat Mohammed, Jens Overgaard, Jan Alsner, Trine Tramm
  • TREATMENT OF RADIATION-INDUCED FIBROSIS
    Publication number: 20120040004
    Abstract: The present invention relates to treatment or prevention of radiation induced fibrosis using TNF-alpha antagonism. Preferably, TNF-alpha is antagonized by direct binding or by inhibition of synthesis. In a preferred embodiment, the invention comprises intraperitoneal administration of a chitosan-siRNA nanoparticle, wherein the siRNA is targeted to the mRNA encoding TNF-alpha.
    Type: Application
    Filed: January 28, 2010
    Publication date: February 16, 2012
    Applicants: REGION MIDTJYLLAND, AARHUS UNIVERSITET
    Inventors: Kenneth Alan Howard, Jørgen Kjems, Isabel Nawroth, Jan Alsner, Jens Overgaard, Flemming Besenbacher