Abstract: A computer implemented method for generating an integrated circuit design (11) is provided. A description of a circuit (16) is provided in a format such as a Hardware Description Language (12). A functional simulation (17) of the description is run to determine functionality of the circuit. A netlist conversion (18) converts the description to a netlist comprising both a single-ended and differential circuit. The netlist conversion (18) converts the description to a single-ended description (24), replaces single-ended cells with differential cells and interconnects the differential cells (25), and exchanges terminals of the differential cells to maintain logic equivalence (26). A simulation with timing (19) is run on the netlist to verify timing characteristics of the circuit. The netlist is then provided to a router to generate a physical circuit layout (20) having both single-ended and differential circuits.