Patents by Inventor Jan-Erik Nystrom

Jan-Erik Nystrom has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds 620
    Publication number: 20080161269
    Abstract: This invention relates to novel compounds having the structural formula I below: and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.
    Type: Application
    Filed: December 19, 2007
    Publication date: July 3, 2008
    Applicants: ASTRAZENECA AB, ASTEX THERAPEUTICS LIMITED
    Inventors: Stefan Berg, Sofia Karlstrom, Karin Kolmodin, Johan Lindstrom, Jan-Erik Nystrom, Fernando Sehgelmeble, Peter Soderman
  • Prodrugs of thrombin inhibitors
    Patent number: 7354905
    Abstract: There is provided compounds of formula I, R1O(O)C—CH2—(R)Cgl-Aze-Pab-R2I wherein R1 and R2 have meanings given in the description, which are useful as prodrugs of inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (eg thrombosis) or as anticoagulants.
    Type: Grant
    Filed: February 12, 2004
    Date of Patent: April 8, 2008
    Assignee: AstraZeneca AB
    Inventors: Thomas Antonsson, David Gustafsson, Kurt-Jürgen Hoffmann, Jan-Erik Nyström, Henrik Sörensen, Mikael Sellén
  • New amidino derivatives and their use as thrombin inhibitors
    Publication number: 20070249578
    Abstract: There is provided compounds of formula I wherein R1, Rx, Y, Ry, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.
    Type: Application
    Filed: June 6, 2007
    Publication date: October 25, 2007
    Applicant: AstraZeneca AB
    Inventors: Tord Inghardt, Olle Karlsson, Marcel Linschoten, Jan-Erik Nystrom
  • Amidino derivatives and their use as thrombin inhibitors
    Patent number: 7241757
    Abstract: There is provided compounds of formula I wherein R1, Rx, Y, Ry, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.
    Type: Grant
    Filed: April 2, 2004
    Date of Patent: July 10, 2007
    Assignee: AstraZeneca AB
    Inventors: Tord Inghardt, Olle Karlsson, Marcel Linschoten, Jan-Erik Nyström
  • Amino acid derivatives
    Patent number: 6921758
    Abstract: There is provided amino acid derivatives of formula I, wherein p, q, R1, R2, R3, R4, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.
    Type: Grant
    Filed: June 26, 2003
    Date of Patent: July 26, 2005
    Assignee: AstraZeneca AB
    Inventors: David Gustafsson, Jan-Erik Nyström
  • Amino acid derivatives and their use as thrombin inhibitors
    Patent number: 6838478
    Abstract: There is provided compounds of formula I, wherein R1, R2, R3, Rx, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.
    Type: Grant
    Filed: April 30, 2001
    Date of Patent: January 4, 2005
    Assignee: AstraZeneca AB
    Inventors: David Gustafsson, Jan-Erik Nyström
  • New amidino derivatives and their use as thrombin inhibitors
    Publication number: 20040186090
    Abstract: There is provided compounds of formula I 1
    Type: Application
    Filed: April 2, 2004
    Publication date: September 23, 2004
    Applicant: AstraZeneca AB
    Inventors: Tord Inghardt, Olle Karlsson, Marcel Linschoten, Jan-Erik Nystrom
  • Prodrugs of thrombin inhibitors
    Publication number: 20040162410
    Abstract: There is provided compounds of formula I,
    Type: Application
    Filed: February 12, 2004
    Publication date: August 19, 2004
    Applicant: AstraZeneca AB
    Inventors: Thomas Antonsson, David Gustafsson, Kurt-Jurgen Hoffmann, Jan-Erik Nystrom, Henrik Sorensen, Mikael Sellen
  • Amidino derivatives and their use as thrombin inhibitors
    Patent number: 6750243
    Abstract: There is provided compounds of formula I wherein R1, Rx, Y, Ry, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.
    Type: Grant
    Filed: March 21, 2000
    Date of Patent: June 15, 2004
    Assignee: AstraZeneća AB
    Inventors: Tord Inghardt, Olle Karlsson, Marcel Linschoten, Jan-Erik Nyström
  • NEW AMINO ACID DERIVATIVES
    Publication number: 20040087647
    Abstract: There is provided amino acid derivatives of formula I, 1
    Type: Application
    Filed: June 26, 2003
    Publication date: May 6, 2004
    Applicant: AstraZeneca AB
    Inventors: David Gustafsson, Jan-Erik Nystrom
  • Thiochromane derivatives and their use as thrombin inhibitors
    Patent number: 6716834
    Abstract: There is provided compounds of formulae I and IA wherein Y, R1, R2, R3, D1 and D2 have meanings given in the description which are useful as, or as prodrugs of, competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.
    Type: Grant
    Filed: November 12, 2002
    Date of Patent: April 6, 2004
    Assignee: AstraZeneca AB
    Inventors: Kjell Andersson, Tord Inghardt, Olle Karlsson, Marcel Linschoten, Jan-Erik Nyström, Gunnel Sundén
  • Amino acid derivatives
    Patent number: 6617320
    Abstract: There is provided amino acid derivatives of formula I, wherein p, q, R1, R2, R3, R4, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as hirombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.
    Type: Grant
    Filed: November 29, 2001
    Date of Patent: September 9, 2003
    Assignee: AstraZeneca AB
    Inventors: David Gustafsson, Jan-Erik Nyström
  • Amidinobenzylamine derivatives and their use as thrombin inhibitors
    Patent number: 6599894
    Abstract: There is provided compounds of formula I wherein R1, R2, Y, R3 and R4 have meanings given in the description which are useful as, or as prodrugs of, competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.
    Type: Grant
    Filed: March 16, 2000
    Date of Patent: July 29, 2003
    Assignee: AstŕaZeneca AB
    Inventors: Tord Inghardt, Jan-Erik Nyström
  • Amidino derivatives and their use as thrombin inhibitors
    Patent number: 6576657
    Abstract: There is provided compounds of formula I, wherein R1, Rx, Y, Ry, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.
    Type: Grant
    Filed: April 30, 2001
    Date of Patent: June 10, 2003
    Assignee: AstraZeneca AB
    Inventors: Olle Karlsson, Marcel Linschoten, Jan-Erik Nyström
  • Prodrugs of thrombin inhibitors
    Publication number: 20020142968
    Abstract: There is provided compounds of formula I,
    Type: Application
    Filed: February 14, 2002
    Publication date: October 3, 2002
    Applicant: AstraZeneca AB
    Inventors: Thomas Antonsson, David Gustafsson, Kurt-Jurgen Hoffmann, Jan-Erik Nystrom, Henrik Sorensen, Mikael Sellen
  • Amino acid derivatives
    Publication number: 20020042396
    Abstract: There is provided amino acid derivatives of formula I, 1
    Type: Application
    Filed: November 29, 2001
    Publication date: April 11, 2002
    Applicant: Astra AB
    Inventors: David Gustafsson, Jan-Erik Nystrom
  • New amidino derivatives and their use as thrombin inhibitors
    Publication number: 20020022612
    Abstract: There is provided compounds of formula I, 1
    Type: Application
    Filed: April 30, 2001
    Publication date: February 21, 2002
    Applicant: AstraZeneca AB
    Inventors: Olle Karlsson, Marcel Linschoten, Jan-Erik Nystrom
  • New amino acid derivatives and their use as thrombin inhibitors
    Publication number: 20020019371
    Abstract: There is provided compounds of formula I, 1
    Type: Application
    Filed: April 30, 2001
    Publication date: February 14, 2002
    Applicant: AstraZeneca AB
    Inventors: David Gustafsson, Jan-Erik Nystrom
  • Amino acid derivatives
    Patent number: 6337343
    Abstract: There is provided amino acid derivatives of formula I, wherein p, q, R1, R2, R3, R4, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.
    Type: Grant
    Filed: March 29, 2000
    Date of Patent: January 8, 2002
    Assignee: AstraZeneca AB
    Inventors: David Gustafsson, Jan-Erik Nyström
  • Compounds
    Patent number: 6337394
    Abstract: There is provided compounds of formula I, wherein R1, R2, R3, Rx, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.
    Type: Grant
    Filed: December 29, 1998
    Date of Patent: January 8, 2002
    Assignee: AstraZeneca AB
    Inventors: Olle Karlsson, Marcel Linschoten, Jan-Erik Nyström