Patents by Inventor Jan KRAEHLING

Jan KRAEHLING has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS AND COMPOSITIONS THAT INHIBIT OR PREVENT LIPOPROTEIN ENTRY INTO THE ENDOTHELIUM
    Publication number: 20210403549
    Abstract: In one aspect, the invention comprises a fusion construct comprising ALKI extracellular domain and a stability enhancing domain. In another aspect, the invention comprises an antibody that interferes with or blocks the ALKI extracellular domain binding to LDL, but does not interfere with or block the ALKI extracellular domain binding to BMP9/10. In yet another aspect, the invention comprises methods of reducing rates of LDL uptake in the endothelial cells of a patient in need thereof by administering the fusion construct or monoclonal antibodies described herein to the patient.
    Type: Application
    Filed: May 17, 2018
    Publication date: December 30, 2021
    Inventors: William C. SESSA, Jan KRAEHLING