Patents by Inventor Jan L. Breslow

Jan L. Breslow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PYRANOPYRAZOLE AND PYRAZOLOPYRIDINE IMMUNOMODULATORS FOR TREATMENT OF AUTOIMMUNE DISEASES
    Publication number: 20220213114
    Abstract: Pyranoyrazoles and pyrazolopyridines of formula I or formula II are disclosed: These compounds inhibit Coagulation Factor XIIa in the presence of thrombin and other coagulation factors. They are useful to treat autoimmune diseases.
    Type: Application
    Filed: March 21, 2022
    Publication date: July 7, 2022
    Applicant: The Rockefeller University
    Inventors: Manish P. PONDA, Harold SELNICK, Melissa EGBERTSON, Jan L. BRESLOW
  • Pyranopyrazole and pyrazolopyridine immunomodulators for treatment of autoimmune diseases
    Patent number: 11312723
    Abstract: Pyranoyrazoles and pyrazolopyridines of formula I or formula II are disclosed: These compounds inhibit Coagulation Factor XIIa in the presence of thrombin and other coagulation factors. They are useful to treat autoimmune diseases.
    Type: Grant
    Filed: November 28, 2018
    Date of Patent: April 26, 2022
    Assignee: THE ROCKEFELLER UNIVERSITY
    Inventors: Manish P. Ponda, Harold Selnick, Melissa Egbertson, Jan L. Breslow
  • PYRANOPYRAZOLE AND PYRAZOLOPYRIDINE IMMUNOMODULATORS FOR TREATMENT OF AUTOIMMUNE DISEASES
    Publication number: 20200369677
    Abstract: Pyranoyrazoles and pyrazolopyridines of formula I or formula II are disclosed: These compounds inhibit Coagulation Factor XIIa in the presence of thrombin and other coagulation factors. They are useful to treat autoimmune diseases.
    Type: Application
    Filed: November 28, 2018
    Publication date: November 26, 2020
    Applicant: The Rockefeller University
    Inventors: Manish P. PONDA, Harold SELNICK, Melissa EGBERTSON, Jan L. BRESLOW
  • Aminoacylindazole immunomodulators for treatment of autoimmune diseases
    Patent number: 10538512
    Abstract: 2-Acylindazole compounds of formula I or formula II are disclosed: These compounds inhibit Coagulation Factor XIIa. They are useful to treat autoimmune diseases.
    Type: Grant
    Filed: May 22, 2017
    Date of Patent: January 21, 2020
    Assignee: The Rockefeller University
    Inventors: Manish P. Ponda, Jan L. Breslow, Harold Selnick, Melissa Egbertson
  • AMINOACYLINDAZOLE IMMUNOMODULATORS FOR TREATMENT OF AUTOIMMUNE DISEASES
    Publication number: 20190202811
    Abstract: 2-Acylindazole compounds of formula I or formula II are disclosed: These compounds inhibit Coagulation Factor XIIa. They are useful to treat autoimmune diseases.
    Type: Application
    Filed: May 22, 2017
    Publication date: July 4, 2019
    Applicant: The Rockefeller University
    Inventors: Manish P. PONDA, Jan L. BRESLOW, Harold SELNICK, Melissa EGBERTSON
  • Method for selective reduction of Lp(a)
    Patent number: 5272166
    Abstract: The present invention relates to methods and corresponding agents for lowering plasma Lp(a) levels by the administration of agents that reduce Lp(a) and selectively separate therefrom the apo(a) component and/or prevent Lp(a) formation. Suitable agents include sulfhydryl reducers, such as N-acetylcysteine. The present method and agents may be administered alone or in conjunction with other therapy for the lowering of LDL cholesterol.
    Type: Grant
    Filed: March 2, 1992
    Date of Patent: December 21, 1993
    Assignee: The Rockefeller University
    Inventors: Jan L. Breslow, Dov Gavish