Patents by Inventor Jan Pen
Jan Pen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20130191944Abstract: Method for the inhibition of carbon flow in the glycolytic direction in a cell by increasing the intracellular availability of trehalose-6-phosphate.Type: ApplicationFiled: January 30, 2012Publication date: July 25, 2013Inventors: Oscar Johannes Maria GODDIJN, Jan Pen, Josephus Christianus Maria Smeekens
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Patent number: 8124840Abstract: Method for the inhibition of carbon flow in the glycolytic direction in a cell by increasing the intracellular availability of trehalose-6-phosphate.Type: GrantFiled: June 13, 2007Date of Patent: February 28, 2012Assignee: Syngenta Mogen B.V.Inventors: Oscar Johannes Maria Goddijn, Jan Pen, Josephus Christianus Maria Smeekens
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Publication number: 20080138903Abstract: Method for the inhibition of carbon flow in the glycolytic direction in a cell by increasing the intracellular availability of trehalose-6-phosphate.Type: ApplicationFiled: June 13, 2007Publication date: June 12, 2008Inventors: Oscar Johannes Maria Goddijn, Jan Pen, Josephus Christianus Maria Smeekens
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Patent number: 7247770Abstract: Method for the inhibition of carbon flow in the glycolytic direction in a cell by increasing the intracellular availability of trehalose-6-phosphate.Type: GrantFiled: October 9, 2003Date of Patent: July 24, 2007Assignee: Syngenta Mogen B.V.Inventors: Oscar Johannes Maria Goddijn, Jan Pen, Josephus Christianus Maria Smeekens
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Publication number: 20060195940Abstract: The present invention provides plants with a modified taste, solids content and/or texture. The invention also provides methods of obtaining such plants via transformation with DNA constructs containing genes encoding enzymes capable of degrading plant polysaccharides and optionally additional genes encoding enzymes which are capable of further modifying the degradation products resulting from the first degradation step.Type: ApplicationFiled: July 30, 2005Publication date: August 31, 2006Inventors: Albert Van Ooyen, Krijn Rietveld, Wilhelmus Quax, Petrus Van Den Elzen, Jan Pen, Andreas Hoekema, Peter Sijmons
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Patent number: 7033627Abstract: A method of catalyzing in vitro reactions using seeds containing enhanced amounts of enzymes is disclosed. The method involves adding transgenic, non-wild type seeds, preferably in a ground form, to a reaction mixture, especially a bakery process and allowing the enzymes in the seeds to increase the rate of reaction. By directly adding the seeds to the reaction mixture the method provides a solution to the expensive and problematic process of extracting and purifying the enzyme. Methods of treatment are also provided whereby a subject lacking a sufficient supply of an enzyme is administered the enzyme in the form of seeds containing enhanced amounts of the enzyme.Type: GrantFiled: February 2, 1998Date of Patent: April 25, 2006Assignees: Syngenta Mogen B.V., Gist-Brocades N.V.Inventors: Albert Johannes Joseph Van Ooyen, Krijn Rietveld, Wilhelmus Johannes Quax, Jan Pen, Andreas Hoekema, Peter Christiaan Sijmons, Teunis Cornelis Verwoerd
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Publication number: 20060005286Abstract: A method of catalyzing in vitro reactions using seeds containing enhanced amounts of enzymes is disclosed. The method involves adding transgenic, non-wild type seeds, preferably in a ground form, to a reaction mixture, especially a bakery process and allowing the enzymes in the seeds to increase the rate of reaction. By directly adding the seeds to the reaction mixture the mehtod provides a solution to the expensive and problematic process of extracting and purifying the enzyme. Methods of treatment are also provided whereby a subject lacking a sufficient supply of an enzyme is administered the enzyme in the form of seeds containing enhanced amounts of the enzyme.Type: ApplicationFiled: August 29, 2005Publication date: January 5, 2006Inventors: Albert Van Ooyen, Krijn Rietveld, Wilhelmus Quax, Jan Pen, Andreas Hoekema, Peter Sijmons, Teunis Verwoerd
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Patent number: 6833490Abstract: The invention involves decreasing the intracellular availability of trehalose-6-phosphate by plant cell transformation with a gene encoding trehalose-6-phosphate phosphatase from E. coli. Phenotypic effects of plant transformation with this gene include stimulation of glycolysis, cell or tissue growth, and metabolism; and inhibition of photosynthesis and bolting.Type: GrantFiled: April 28, 1999Date of Patent: December 21, 2004Assignee: Mogen International N.V.Inventors: Oscar Johannes Maria Goddijn, Jan Pen, Josephus Christianus Maria Smeekens
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Publication number: 20040093641Abstract: Method for the inhibition of carbon flow in the glycolytic direction in a cell by increasing the intracellular availability of trehalose-6-phosphate.Type: ApplicationFiled: October 9, 2003Publication date: May 13, 2004Applicant: MOGEN INTERNATIONAL N.V.Inventors: Oscar Johannes Maria Goddijn, Jan Pen, Josephus Christianus Maria Smeekens
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Publication number: 20040088750Abstract: A method of catalyzing in vitro reactions using seeds containing enhanced amounts of enzymes is disclosed. The method involves adding transgenic, non-wild type seeds, preferably in a ground form, to a reaction mixture, especially a bakery process and allowing the enzymes in the seeds to increase the rate of reaction. By directly adding the seeds to the reaction mixture the method provides a solution to the expensive and problematic process of extracting and purifying the enzyme. Methods of treatment are also provided whereby a subject lacking a sufficient supply of an enzyme is administered the enzyme in the form of seeds containing enhanced amounts of the enzyme.Type: ApplicationFiled: February 2, 1998Publication date: May 6, 2004Inventors: ALBERT JOHANNES JOSEPH VAN OOIJEN, KRIJN RIETVELD, WILHELMUS JOHANNES QUAX, JAN PEN, ANDREAS HOEKEMA, PETER CHRISTIAAN SIJMONS, TEUNIS CORNELIS VERWOERD
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Publication number: 20030177531Abstract: A method of modification of the development and/or composition of cells, tissues, or organs in vivo in plants by inhibiting the level of an endogenous trehalase is provided. The cells, tissues, or organs have been genetically altered to comprise a DNA sequence encoding a trehalase inhibitor. The DNA sequence is capable of expressing an RNA that is at least partially complementary to an RNA produced by a DNA sequence encoding the endogenous trehalase. Alternatively, the DNA sequence comprises a DNA sequence which is identical to a DNA sequence encoding the endogenous trehalase. The modification is other than to increase production or accumulation of trehalose.Type: ApplicationFiled: July 15, 2002Publication date: September 18, 2003Applicant: Mogen International N.V.Inventors: Oscar Johannes Maria Goddijn, Jan Pen, Josephus Christianus Maria Smeekens, Maria Theresia Smits
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Patent number: 6022846Abstract: The present invention provides for the expression of phytase in transgenic plants or plant organs and methods for the production of such plants. DNA expression constructs are provided for the transformation of plants with a gene encoding phytase under the control of regulatory sequences which are capable of directing the expression of phytase. These regulatory sequences include sequences capable of directing transcription in plants, either constitutively, or stage and/or tissue specific, depending on the use of the plant or parts thereof. The transgenic plants and plant organs provided by the present invention may be applied to a variety of industrial processes either directly, e.g. in animal feeds or alternatively, the expressed phytase may be extracted and if desired, purified before application.Type: GrantFiled: June 15, 1998Date of Patent: February 8, 2000Assignee: Mogen International and Gist-brocades N.V.Inventors: Albert J. J. Van Ooijen, Krun Rietveld, Andreas Hoekema, Jan Pen, Peter Christian Sijmons, Teunis Cornelis Verwoerd
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Patent number: 5925804Abstract: A nucleic acid having (i) a DNA molecule which, when expressed in a plant or plant cell, increases the trehalose content of the plant or plant cell, the DNA molecule encoding an E. coli trehalose phosphate synthase, and (ii) a plant expressible promoter operatively coupled to the DNA molecule. Also, a method for obtaining a plant with increased trehalose production by introducing into a recipient cell of a plant, a plant expressible gene which, when expressed in a plant or plant cell increases the trehalose content of the plant or plant cell. The plant expressible gene is an E. coli trehalose phosphate synthase gene which is operably linked to: a) a transcriptional initiation region that is functional in the plant, and b) a DNA molecule encoding a selectable marker gene that is functional in the plant. The method includes a step of regenerating a plant from the recipient cell under conditions that allow for selection for the presence of the selectable marker gene.Type: GrantFiled: December 21, 1995Date of Patent: July 20, 1999Assignee: Mogen International NVInventors: Andreas Hoekema, Jan Pen, Mirjam Petronella Does, Petrus Josephus Maria Van Den Elzen
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Patent number: 5770413Abstract: The present invention provides for the expression of phytase in transgenic plants or plant organs and methods for the production of such plants. DNA expression constructs are provided for the transformation of plants with a gene encoding phytase under the control of regulatory sequences which are capable of directing the expression of phytase. These regulatory sequences include sequences capable of directing transcription in plants, either constitutively, or stage and/or tissue specific, depending on the use of the plant or parts thereof. The transgenic plants and plant organs provided by the present invention may be applied to a variety of industrial processes either directly, e.g. in animal feeds or alternatively, the expressed phytase may be extracted and if desired, purified before application.Type: GrantFiled: August 7, 1996Date of Patent: June 23, 1998Assignees: Gist-brocades, B.V., Mogen InternationalInventors: Albert J. J. Van Ooijen, Krijn Rietveld, Andreas Hoekema, Jan Pen, Peter Christian Sijmons, Teunis Cornelis Verwoerd
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Patent number: 5714474Abstract: A method of catalyzing in vitro reactions using seeds containing enhanced amounts of enzymes is disclosed. The method involves adding transgenic, non-wild type seeds, preferably in a ground form, to a reaction mixture and allowing the enzymes in the seeds to increase the rate of reaction. By directly adding the seeds to the reaction mixture the method provides a solution to the expensive and problematic process of extracting and purifying the enzyme. Methods of treatment are also provided whereby a subject lacking a sufficient supply of an enzyme is administered the enzyme in the form of seeds containing enhanced amounts of the enzyme.Type: GrantFiled: April 2, 1996Date of Patent: February 3, 1998Assignee: Mogen InternationalInventors: Albert J. J. Van Ooijen, Krijn Rietveld, Andreas Hoekema, Jan Pen, Peter Christian Sijmons, Teunis Cornelis Verwoerd, Wilhemus Johannes Quax
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Patent number: 5705375Abstract: The present invention provides plants with a modified taste, solids content and/or texture. The invention also provides methods of obtaining such plants via transformation with DNA constructs containing genes encoding enzymes capable of degrading plant polysaccharides and optionally additional genes encoding enzymes which are capable of further modifying the degradation products resulting from the first degradation step.Type: GrantFiled: June 3, 1994Date of Patent: January 6, 1998Assignee: MOGEN International, N.V.Inventors: Albert Johannes Joseph Van Ooyen, Krijn Rietveld, Wilhelmus Johannes Quax, Petrus Josephus Maria Van Den Elzen, Jan Pen, Andreas Hoekema, Peter Christiaan Sijmons
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Patent number: 5593963Abstract: The present invention provides for the expression of phytase in transgenic plants or plant organs and methods for the production of such plants. DNA expression constructs are provided for the transformation of plants with a gene encoding phytase under the control of regulatory sequences which are capable of directing the expression of phytase. These regulatory sequences include sequences capable of directing transcription in plants, either constitutively, or stage and/or tissue specific, depending on the use of the plant or parts thereof. The transgenic plants and plant organs provided by the present invention may be applied to a variety of industrial processes either directly, e.g. in animal feeds or alternatively, the expressed phytase may be extracted and if desired, purified before application.Type: GrantFiled: November 2, 1993Date of Patent: January 14, 1997Assignees: Mogen International, Gist-brocades, B.V.Inventors: Albert J. J. Van Ooijen, Krijn Rietveld, Andreas Hoekema, Jan Pen, Peter C. Sijmons, Teunis C. Verwoerd
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Patent number: 5543576Abstract: A method of catalyzing in vitro reactions using seeds containing enhanced amounts of enzymes is disclosed. The method involves adding transgenic, non-wild type seeds, preferably in a ground form, to a reaction mixture and allowing the enzymes in the seeds to increase the rate of reaction. By directly adding the seeds to the reaction mixture the method provides a solution to the expensive and problematic process of extracting and purifying the enzyme. Methods of treatment are also provided whereby a subject lacking a sufficient supply of an enzyme is administered the enzyme in the form of seeds containing enhanced amounts of the enzyme.Type: GrantFiled: November 2, 1993Date of Patent: August 6, 1996Assignees: Mogen International, Gist-BrocadesInventors: Albert J. J. van Ooijen, Krijn Rietveld, Andreas Hoekema, Jan Pen, Peter C. Sijmons, Teunis C. Verwoerd, Wilhemus J. Quax