Abstract: The present invention provides a vaccine product comprising a container, wherein the container comprises an internal surface, the internal surface comprising either (i) silicon dioxide, (ii) a polymeric material, or (iii) a surface treated with ethylene oxide; and a vaccine composition within the container in contact with the internal surface, wherein the vaccine composition comprises virus particles.

Abstract: Treatment fields can be produced as part of a treatment plan that achieves a desired balance between field delivery time and dose based on machine parameters and knowledge, such as machine-specific beam production, transport and scanning logic, and/or a maximum treatment time value. The treatment parameters can be adjusted using a graphical user interface so that treatment time or dosimetry is prioritized. As a result, the overall treatment time is reduced, and hence treatment quality and patient experience are improved.

Abstract: Multi-criteria optimization of radiation therapy tools for receiving a plurality of criteria including one or more sets of competing objectives. The competing objective can include delivery time criteria, fractionation criteria or similar time-based criteria. One or more radiation therapy plans can be determined based on a multi-criteria optimization of the plurality of criteria for the radiation therapy treatment. The one or more optimized radiation therapy plans can be output for consideration by one or more members of a radiation oncology team.

Abstract: In various embodiments, a radiation therapy method can include loading a planning image of a target in a human. In addition, the position of the target can be monitored. A computation can be made of an occurrence of substantial alignment between the position of the target and the target of the planning image. Furthermore, after the computing, a beam of radiation is triggered to deliver a dosage to the target in a short period of time (e.g., less than a second).

Abstract: Multi-criteria optimization of radiation therapy tools for receiving a plurality of criteria including one or more sets of competing objectives. The competing objective can include delivery time criteria, fractionation criteria or similar time-based criteria. One or more radiation therapy plans can be determined based on a multi-criteria optimization of the plurality of criteria for the radiation therapy treatment. The one or more optimized radiation therapy plans can be output for consideration by one or more members of a radiation oncology team.

Abstract: A control system is described which provides a user interface that displays a clear graphical representation of relevant data for a particle radiation therapy system (such as a pencil-beam proton therapy system) for treating multiple beam fields as efficiently as possible. The user interface allows a user to visualize a treatment session, select one or multiple beam fields to include in one or more beam applications, and dissociate beam fields previously grouped if necessary. Further embodiments extend the ability to initiate the application of the generated proton therapy beam and the grouping of beam fields to be performed remotely from the treatment room itself, and even automatically, reducing the need for manual interventions to setup between fields.

Abstract: In various embodiments, a radiation therapy method can include loading a planning image of a target in a human. In addition, the position of the target can be monitored. A computation can be made of an occurrence of substantial alignment between the position of the target and the target of the planning image. Furthermore, after the computing, a beam of radiation is triggered to deliver a dosage to the target in a short period of time (e.g., less than a second).

Abstract: Irradiation device for irradiating an irradiation object with heavy charged particles, comprising a support for the irradiation object, and an irradiation nozzle irradiating a charged particle beam towards the irradiation object, wherein the beam is deflected within the irradiation nozzle. The support for the irradiation object is moveable at least horizontally, and the irradiation nozzle is moveable at least vertically and rotatable around a nozzle swivel axis along which the particle beam enters into the irradiation nozzle.

Abstract: A system (IPS) and related method for fractional flow reserve, FFR, simulation. The simulation for a range of FFR values for a vasculature portion is based on a composite transfer function which is combined from a weighted sum of global effect transfer functions he, each representing a distinct physical effect that causes a pressure drop. The weights we are gotten from a previous training phase against pressure pi versus flow rate fi 5 sample measurements associated with respective vasculature geometries. The simulated range of FFR values is visualized in a graphics display (GD) as a function of pressure and flow rate values within respective intervals.

Abstract: A control system is described which provides a user interface that displays a clear graphical representation of relevant data for a particle radiation therapy system (such as a pencil-beam proton therapy system) for treating multiple beam fields as efficiently as possible. The user interface allows a user to visualize a treatment session, select one or multiple beam fields to include in one or more beam applications, and dissociate beam fields previously grouped if necessary. Further embodiments extend the ability to initiate the application of the generated proton therapy beam and the grouping of beam fields to be performed remotely from the treatment room itself, and even automatically, reducing the need for manual interventions to setup between fields.

Abstract: System and method for shaping the intensity profile of a radiation beam incident on a target volume. Embodiments according to the present disclosure include a multi-leaf collimator (MLC) capable of sharpening (e.g., “trimming”) a proton beam, the MLC having a reduced overall weight. Leaves of the MLC according to embodiments of the present disclosure have two regions of different density, where a high density region is proximal to a radiation beam so as to block a portion of the beam, and a lower density region provides structural integrity to the leaf while reducing overall MLC weight.

Abstract: A control system is described which provides a user interface that displays a clear graphical representation of relevant data for a particle radiation therapy system (such as a pencil-beam proton therapy system) for treating multiple beam fields as efficiently as possible. The user interface allows a user to visualize a treatment session, select one or multiple beam fields to include in one or more beam applications, and dissociate beam fields previously grouped if necessary. Further embodiments extend the ability to initiate the application of the generated proton therapy beam and the grouping of beam fields to be performed remotely from the treatment room itself, and even automatically, reducing the need for manual interventions to setup between fields.

Abstract: A control system is described which provides a user interface that displays a clear graphical representation of relevant data for a particle radiation therapy system (such as a pencil-beam proton therapy system) for treating multiple beam fields as efficiently as possible. The user interface allows a user to visualize a treatment session, select one or multiple beam fields to include in one or more beam applications, and dissociate beam fields previously grouped if necessary. Further embodiments extend the ability to initiate the application of the generated proton therapy beam and the grouping of beam fields to be performed remotely from the treatment room itself, and even automatically, reducing the need for manual interventions to setup between fields.

Abstract: System and method for shaping the intensity profile of a radiation beam incident on a target volume. Embodiments according to the present disclosure include a multi-leaf collimator (MLC) capable of sharpening (e.g., “trimming”) a proton beam, the MLC having a reduced overall weight. Leaves of the MLC according to embodiments of the present disclosure have two regions of different density, where a high density region is proximal to a radiation beam so as to block a portion of the beam, and a lower density region provides structural integrity to the leaf while reducing overall MLC weight.

Abstract: A system (IPS) and related method for fractional flow reserve, FFR, simulation. The simulation for a range of FFR values for a vasculature portion is based on a composite transfer function which is combined from a weighted sum of global effect transfer functions he, each representing a distinct physical effect that causes a pressure drop. The weights we are gotten from a previous training phase against pressure pi versus flow rate fi 5 sample measurements associated with respective vasculature geometries. The simulated range of FFR values is visualized in a graphics display (GD) as a function of pressure and flow rate values within respective intervals.

Abstract: Irradiation device for irradiating an irradiation object with heavy charged particles, comprising a support for the irradiation object, and an irradiation nozzle irradiating a charged particle beam towards the irradiation object, wherein the beam is deflected within the irradiation nozzle. The support for the irradiation object is moveable at least horizontally, and the irradiation nozzle is moveable at least vertically and rotatable around a nozzle swivel axis along which the particle beam enters into the irradiation nozzle.

Abstract: Systems and methods are provided to perform efficient, automatic cyclotron initialization, calibration, and beam adjustment. A process is provided that allows the automation of the initialization of a cyclotron after overnight or maintenance imposed shutdown. In one embodiment, five independent cyclotron system states are defined and the transition between one state to another may be automated, e.g., by the control system of the cyclotron. According to these embodiments, it is thereby possible to achieve beam operation after shutdown with minimal manual input. By applying an automatic procedure, all active devices of the cyclotron (e.g., RF system, extraction deflectors, ion source) are respectively ramped to predefined parameters.

Abstract: Systems and methods are provided to perform efficient, automatic cyclotron initialization, calibration, and beam adjustment. A process is provided that allows the automation of the initialization of a cyclotron after overnight or maintenance imposed shutdown. In one embodiment, five independent cyclotron system states are defined and the transition between one state to another may be automated, e.g., by the control system of the cyclotron. According to these embodiments, it is thereby possible to achieve beam operation after shutdown with minimal manual input. By applying an automatic procedure, all active devices of the cyclotron (e.g., RF system, extraction deflectors, ion source) are respectively ramped to predefined parameters.

Abstract: Systems and methods are provided to perform efficient, automatic cyclotron initialization, calibration, and beam adjustment. A process is provided that allows the automation of the initialization of a cyclotron after overnight or maintenance imposed shutdown. In one embodiment, five independent cyclotron system states are defined and the transition between one state to another may be automated, e.g., by the control system of the cyclotron. According to these embodiments, it is thereby possible to achieve beam operation after shutdown with minimal manual input. By applying an automatic procedure, all active devices of the cyclotron (e.g., RF system, extraction deflectors, ion source) are respectively ramped to predefined parameters.

Abstract: Systems and methods are provided to perform efficient, automatic cyclotron initialization, calibration, and beam adjustment. A process is provided that allows the automation of the initialization of a cyclotron after overnight or maintenance imposed shutdown. In one embodiment, five independent cyclotron system states are defined and the transition between one state to another may be automated, e.g., by the control system of the cyclotron. According to these embodiments, it is thereby possible to achieve beam operation after shutdown with minimal manual input. By applying an automatic procedure, all active devices of the cyclotron (e.g., RF system, extraction deflectors, ion source) are respectively ramped to predefined parameters.