Patents by Inventor Jan Van De Velde

Jan Van De Velde has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240043938
    Abstract: The present invention generally relates to the field of cancer, in particular to cancers having microsatellite instability (MSI) and/or mismatch repair (MMR-) deficiency. Examples of such cancers include many colorectal, gastric, and endometrial tumors. Accordingly, the present invention provides a novel diagnostic marker panel for analyzing MSI loci, together with methods and kits of using said panel in the detection of cancers having microsatellite instability (MSI) and/or mismatch repair (MMR-) deficiency.
    Type: Application
    Filed: June 9, 2023
    Publication date: February 8, 2024
    Inventors: Bram De Craene, Klaas Decanniere, Jan Van De Velde, Geert Maertens
  • Patent number: 11713488
    Abstract: The present invention generally relates to the field of cancer, in particular to cancers having microsatellite instability (MSI) and/or mismatch repair (MMR-) deficiency. Examples of such cancers include many colorectal, gastric, and endometrial tumors. Accordingly, the present invention provides a novel diagnostic marker panel for analyzing MSI loci, together with methods and kits of using said panel in the detection of cancers having microsatellite instability (MSI) and/or mismatch repair (MMR-) deficiency.
    Type: Grant
    Filed: January 22, 2019
    Date of Patent: August 1, 2023
    Assignee: BIOCARTIS NV
    Inventors: Bram De Craene, Klaas Decanniere, Jan Van De Velde, Geert Maertens
  • Publication number: 20230220446
    Abstract: The field of the invention generally relates to cancer, including methods for diagnosing, prognosing, and treating cancer. In particular, the field of the invention relates to novel signatures of unique sets of point mutations involving a change of a cytosine or a guanidine, and methods, systems, and components thereof based upon the novel signature for identifying tumor samples having increased tumor mutational burden (TMB). Both the signatures and the methods, systems, and components thereof may be utilized for identifying cancer patients, microsatellite stable-cancer patients in particular, who will effectively respond to immune checkpoint blockade therapy.
    Type: Application
    Filed: July 10, 2020
    Publication date: July 13, 2023
    Inventors: Jan VAN DE VELDE, Bram DE CRAENE, Aleksandra Katarzyna ZWOLINSKA, Hui ZHAO, Diether LAMBRECHTS, Geert MAERTENS
  • Publication number: 20210005286
    Abstract: The present invention relates to the use of wavelet transform to analyze raw melting curve data of nucleic acids. The effect is decreased noise sensitive calculations and increased computational efficiency and speed. The invention is particularly suitable for classifying test samples involving the combined analysis of several, multiplexed targets within one experiment generating large raw datasets requiring discrimination of minute variations in the data.
    Type: Application
    Filed: January 22, 2019
    Publication date: January 7, 2021
    Inventors: Bram De Craene, Klaas Decanniere, Jan Van De Velde
  • Publication number: 20200399705
    Abstract: The present invention generally relates to the field of cancer, in particular to cancers having microsatellite instability (MSI) and/or mismatch repair (MMR-) deficiency. Examples of such cancers include many colorectal, gastric, and endometrial tumors. Accordingly, the present invention provides a novel diagnostic marker panel for analyzing MSI loci, together with methods and kits of using said panel in the detection of cancers having microsatellite instability (MSI) and/or mismatch repair (MMR-) deficiency.
    Type: Application
    Filed: January 22, 2019
    Publication date: December 24, 2020
    Inventors: Bram De Craene, Klaas Decanniere, Jan Van De Velde