Patents by Inventor Jan Zygmunt

Jan Zygmunt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220142969
    Abstract: The present invention discloses the water-soluble cannabinoid-containing solid dispersion and method of preparation thereof. The solid dispersion of the invention comprises one or more cannabinoids as active ingredients, a hydrophilic polymeric carrier, an antioxidant and optionally the palatability-improving agent. The solid dispersion is suitable for oral delivery application in form of solid material or an aqueous colloidal dispersion or for transdermal delivery application.
    Type: Application
    Filed: December 31, 2020
    Publication date: May 12, 2022
    Inventors: Jan ZYGMUNT, Thomas BLAKELEY
  • Publication number: 20200237708
    Abstract: The present invention relates to a method for the treatment of cancer in a cancer patient.
    Type: Application
    Filed: April 15, 2020
    Publication date: July 30, 2020
    Inventors: Jan Zygmunt, James Ferrara, James D. McChesney
  • Patent number: 10639293
    Abstract: The present invention relates to a method for the treatment of cancer in a cancer patient.
    Type: Grant
    Filed: January 14, 2019
    Date of Patent: May 5, 2020
    Assignee: Tapestry Pharmaceuticals, Inc.
    Inventors: Jan Zygmunt, James Ferrara, James D. McChesney
  • Publication number: 20190142784
    Abstract: Provided herein are compounds, compositions containing the compounds, and methods for the treatment of cancer in a cancer patient. In particular, the compounds are made by a process comprising treating a first compound represented by either Formula G? or Formula M?: with a second compound of generalized formula R8R9C(OCH3)2 and an acid selected from the group consisting of camphor sulfonic acid (CSA), p-toluene sulfonic acid (PTSA), hydrochloric acid (HCl) and acetic acid (AcOH), wherein R1 and R2 are each selected from H, an alkyl group, an olefinic group, an aromatic group, an O-alkyl group, an O-olefinic group, or an O-aromatic group; R7 is an alkyl group, an olefinic group, or an aromatic group; P1 is a hydroxyl protecting group; P5 is H or an acid labile protecting group at the 7-O position; R8 is H, alkyl group, olefinic or aromatic group; and R9 is: H, alkyl group, olefinic or aromatic or is as defined in the specification.
    Type: Application
    Filed: January 14, 2019
    Publication date: May 16, 2019
    Inventors: Jan Zygmunt, James Ferrara, James D. McChesney
  • Patent number: 10238621
    Abstract: Provided herein are compounds, compositions containing the compounds, and methods for the treatment of cancer in a cancer patient. In particular, the compounds are made by a process comprising treating a first compound represented by either Formula G? or Formula M?: with a second compound of generalized formula R8R9C(OCH3)2 and an acid selected from the group consisting of camphor sulfonic acid (CSA), p-toluene sulfonic acid (PTSA), hydrochloric acid (HCl) and acetic acid (AcOH), wherein R1 and R2 are each selected from H, an alkyl group, an olefinic group, an aromatic group, an O-alkyl group, an O-olefinic group, or an O-aromatic group; R7 is an alkyl group, an olefinic group, or an aromatic group; P1 is a hydroxyl protecting group; P5 is H or an acid labile protecting group at the 7-O position; R8 is H, alkyl group, olefinic or aromatic group; and R9 is: H, alkyl group, olefinic or aromatic or is as defined in the specification.
    Type: Grant
    Filed: October 9, 2017
    Date of Patent: March 26, 2019
    Assignee: TAPESTRY PHARMACEUTICALS, INC.
    Inventors: Jan Zygmunt, James Ferrara, James D. McChesney
  • Publication number: 20180125811
    Abstract: Provided herein are compounds, compositions containing the compounds, and methods for the treatment of cancer in a cancer patient. In particular, the compounds are made by a process comprising treating a first compound represented by either Formula G? or Formula M?: with a second compound of generalized formula R8R9C(OCH3)2 and an acid selected from the group consisting of camphor sulfonic acid (CSA), p-toluene sulfonic acid (PTSA), hydrochloric acid (HCl) and acetic acid (AcOH), wherein R1 and R2 are each selected from H, an alkyl group, an olefinic group, an aromatic group, an O-alkyl group, an O-olefinic group, or an O-aromatic group; R7 is an alkyl group, an olefinic group, or an aromatic group; P1 is a hydroxyl protecting group; P5 is H or an acid labile protecting group at the 7-O position; R8 is H, alkyl group, olefinic or aromatic group; and R9 is: H, alkyl group, olefinic or aromatic or is as defined in the specification.
    Type: Application
    Filed: October 9, 2017
    Publication date: May 10, 2018
    Inventors: Jan Zygmunt, James Ferrara, James D. McChesney
  • Patent number: 9926245
    Abstract: Methods to synthesize fuels and chemicals from natural gas liquids are described. Higher alcohols are synthesized starting from natural gas liquid compounds by converting an alkane from a NGL to an olefin, dimerizing said olefin, and, hydrating said olefin product to form a higher alcohol. Higher alcohols are synthesized starting from natural gas liquid compounds by converting an alkane from a NGL to an olefin, oxidizing the olefin to form a ketone or aldehyde and, hydrogenating the aldehyde or ketone product to form a higher alcohol. Thus, NGL component butane may be dehydrogenated to form butane, butylene is oxidized in the presence of a catalyst to form methylethyl ketone and methylethyl ketone hydrogenated to form butanol.
    Type: Grant
    Filed: September 29, 2014
    Date of Patent: March 27, 2018
    Assignee: Pioneer Energy
    Inventors: John T Henri, Jan Zygmunt, Robert Zubrin
  • Patent number: 9820962
    Abstract: Provided herein are compounds, compositions containing the compounds, and methods for the treatment of cancer in a cancer patient. In particular, the compounds are made by a process comprising treating a first compound represented by either Formula G? or Formula M?: with a second compound of generalized formula R8R9C(OCH3)2 and an acid selected from the group consisting of camphor sulfonic acid (CSA), p-toluene sulfonic acid (PTSA), hydrochloric acid (HCl) and acetic acid (AcOH), wherein R1 and R2 are each selected from H, an alkyl group, an olefinic group, an aromatic group, an O-alkyl group, an O-olefinic group, or an O-aromatic group; R7 is an alkyl group, an olefinic group, or an aromatic group; P1 is a hydroxyl protecting group; P5 is H or an acid labile protecting group at the 7-O position; R8 is H, alkyl group, olefinic or aromatic group; and R9 is: H, alkyl group, olefinic or aromatic or is as defined in the specification.
    Type: Grant
    Filed: July 27, 2016
    Date of Patent: November 21, 2017
    Assignee: Tapestry Pharmaceuticals, Inc.
    Inventors: Jan Zygmunt, James Ferrara, James D. McChesney
  • Patent number: 9656932
    Abstract: In one embodiment, the present application discloses methods to selectively synthesize higher alcohols and hydrocarbons useful as fuels and industrial chemicals from syngas and biomass. Ketene and ketonization chemistry along with hydrogenation reactions are used to synthesize fuels and chemicals. In another embodiment, ketene used to form fuels and chemicals may be manufactured from acetic acid which in turn can be synthesized from synthesis gas which is produced from coal, biomass, natural gas, etc.
    Type: Grant
    Filed: May 12, 2015
    Date of Patent: May 23, 2017
    Assignee: PIONEER ENERGY
    Inventors: John T. Henri, Jan Zygmunt, Mark Berggren, Robert Zubrin
  • Patent number: 9611186
    Abstract: In one embodiment, the present application discloses methods to selectively synthesize higher alcohols and hydrocarbons useful as fuels and industrial chemicals from syngas and biomass. Ketene and ketonization chemistry along with hydrogenation reactions are used to synthesize fuels and chemicals. In another embodiment, ketene used to form fuels and chemicals may be manufactured from acetic acid which in turn can be synthesized from synthesis gas which is produced from coal, biomass, natural gas, etc.
    Type: Grant
    Filed: November 8, 2012
    Date of Patent: April 4, 2017
    Assignee: PIONEER ENERGY
    Inventors: John Henri, Jan Zygmunt, Mark Berggren, Robert Zubrin
  • Publication number: 20160331718
    Abstract: Provided herein are compounds, compositions containing the compounds, and methods for the treatment of cancer in a cancer patient. In particular, the compounds are made by a process comprising treating a first compound represented by either Formula G? or Formula M?: with a second compound of generalized formula R8R9C(OCH3)2 and an acid selected from the group consisting of camphor sulfonic acid (CSA), p-toluene sulfonic acid (PTSA), hydrochloric acid (HCl) and acetic acid (AcOH), wherein R1 and R2 are each selected from H, an alkyl group, an olefinic group, an aromatic group, an O-alkyl group, an O-olefinic group, or an O-aromatic group; R7 is an alkyl group, an olefinic group, or an aromatic group; P1 is a hydroxyl protecting group; P5 is H or an acid labile protecting group at the 7-O position; R8 is H, alkyl group, olefinic or aromatic group; and R9 is: H, alkyl group, olefinic or aromatic or is as defined in the specification.
    Type: Application
    Filed: July 27, 2016
    Publication date: November 17, 2016
    Inventors: Jan ZYGMUNT, James FERRARA, James D. McCHESNEY
  • Patent number: 9440898
    Abstract: In one embodiment, the present application discloses methods to selectively synthesize higher alcohols and hydrocarbons useful as fuels and industrial chemicals from syngas and biomass. Ketene and ketonization chemistry along with hydrogenation reactions are used to synthesize fuels and chemicals. In another embodiment, ketene used to form fuels and chemicals may be manufactured from acetic acid which in turn can be synthesized from synthesis gas which is produced from coal, biomass, natural gas, etc.
    Type: Grant
    Filed: July 30, 2015
    Date of Patent: September 13, 2016
    Assignee: PIONEER ENERGY
    Inventors: John T. Henri, Jan Zygmunt, Mark Berggren, Robert Zubrin
  • Patent number: 9402824
    Abstract: Provided herein are compounds, compositions containing the compounds, and methods for the treatment of cancer in a cancer patient. In particular, the compounds are made by a process comprising treating a first compound represented by either Formula G? or Formula M?: with a second compound of generalized formula R8R9C(OCH3)2 and an acid selected from the group consisting of camphor sulfonic acid (CSA), p-toluene sulfonic acid (PTSA), hydrochloric acid (HCl) and acetic acid (AcOH), wherein R1 and R2 are each selected from H, an alkyl group, an olefinic group, an aromatic group, an O-alkyl group, an O-olefinic group, or an O-aromatic group; R7 is an alkyl group, an olefinic group, or an aromatic group; P1 is a hydroxyl protecting group; P5 is H or an acid labile protecting group at the 7-O position; R8 is H, alkyl group, olefinic or aromatic group; and R9 is: H, alkyl group, olefinic or aromatic or is as defined in the specification.
    Type: Grant
    Filed: January 23, 2015
    Date of Patent: August 2, 2016
    Assignee: Tapestry Pharmaceuticals, Inc.
    Inventors: Jan Zygmunt, James Ferrara, James D. McChesney
  • Publication number: 20160200645
    Abstract: Methods to synthesize fuels and chemicals from natural gas liquids are described. Higher alcohols are synthesized starting from natural gas liquid compounds by converting an alkane from a NGL to an olefin, dimerizing said olefin, and, hydrating said olefin product to form a higher alcohol. Higher alcohols are synthesized starting from natural gas liquid compounds by converting an alkane from a NGL to an olefin, oxidizing the olefin to form a ketone or aldehyde and, hydrogenating the aldehyde or ketone product to form a higher alcohol. Thus, NGL component butane may be dehydrogenated to form butane, butylene is oxidized in the presence of a catalyst to form methylethyl ketone and methylethyl ketone hydrogenated to form butanol.
    Type: Application
    Filed: September 29, 2014
    Publication date: July 14, 2016
    Applicant: PIONEER ENERGY INC
    Inventors: John T Henri, Jan Zygmunt, Robert Zubrin
  • Publication number: 20160031776
    Abstract: In one embodiment, the present application discloses methods to selectively synthesize higher alcohols and hydrocarbons useful as fuels and industrial chemicals from syngas and biomass. Ketene and ketonization chemistry along with hydrogenation reactions are used to synthesize fuels and chemicals. In another embodiment, ketene used to form fuels and chemicals may be manufactured from acetic acid which in turn can be synthesized from synthesis gas which is produced from coal, biomass, natural gas, etc.
    Type: Application
    Filed: July 30, 2015
    Publication date: February 4, 2016
    Applicant: Pioneer Energy, Inc.
    Inventors: John T. Henri, Jan Zygmunt, Mark Berggren, Robert Zubrin
  • Publication number: 20150353854
    Abstract: Methods to synthesize useful alcohol and aromatic hydrocarbon products from sorbitol derived from sugars are described. Sorbitol is dehydrated to form furans such as 2-acetylfuran which is hydrogenated to form hexanols, ethyl tetrahydrofuran, etc useful as fuels and chemicals for industry and commerce. Sorbitol may also be heated over a dehydrating catalyst to form aromatic hydrocarbons useful as fuels.
    Type: Application
    Filed: June 9, 2014
    Publication date: December 10, 2015
    Applicant: PIONEER ENERGY INC
    Inventors: John T Henri, Jan Zygmunt, Robert Zubrin
  • Publication number: 20150267135
    Abstract: In one embodiment, the present application discloses methods to selectively synthesize higher alcohols and hydrocarbons useful as fuels and industrial chemicals from syngas and biomass. Ketene and ketonization chemistry along with hydrogenation reactions are used to synthesize fuels and chemicals. In another embodiment, ketene used to form fuels and chemicals may be manufactured from acetic acid which in turn can be synthesized from synthesis gas which is produced from coal, biomass, natural gas, etc.
    Type: Application
    Filed: April 23, 2015
    Publication date: September 24, 2015
    Applicant: Pioneer Energy, Inc.
    Inventors: John Henri, Jan Zygmunt, Mark Berggren, Robert Zubrin
  • Publication number: 20150246862
    Abstract: In one embodiment, the present application discloses methods to selectively synthesize higher alcohols and hydrocarbons useful as fuels and industrial chemicals from syngas and biomass. Ketene and ketonization chemistry along with hydrogenation reactions are used to synthesize fuels and chemicals. In another embodiment, ketene used to form fuels and chemicals may be manufactured from acetic acid which in turn can be synthesized from synthesis gas which is produced from coal, biomass, natural gas, etc.
    Type: Application
    Filed: May 12, 2015
    Publication date: September 3, 2015
    Applicant: Pioneer Energy, Inc.
    Inventors: John T. Henri, Jan Zygmunt, Mark Berggren, Robert Zubrin
  • Patent number: 9080119
    Abstract: In one embodiment, the present application discloses methods to selectively synthesize higher alcohols and hydrocarbons useful as fuels and industrial chemicals from syngas and biomass. Ketene and ketonization chemistry along with hydrogenation reactions are used to synthesize fuels and chemicals. In another embodiment, ketene used to form fuels and chemicals may be manufactured from acetic acid which in turn can be synthesized from synthesis gas which is produced from coal, biomass, natural gas, etc.
    Type: Grant
    Filed: March 20, 2013
    Date of Patent: July 14, 2015
    Assignee: PIONEER ENERGY
    Inventors: John Henri, Jan Zygmunt, Mark Berggren, Robert Zubrin
  • Patent number: 9040757
    Abstract: In one embodiment, the present application discloses methods to selectively synthesize higher alcohols and hydrocarbons useful as fuels and industrial chemicals from syngas and biomass. Ketene and ketonization chemistry along with hydrogenation reactions are used to synthesize fuels and chemicals. In another embodiment, ketene used to form fuels and chemicals may be manufactured from acetic acid which in turn can be synthesized from synthesis gas which is produced from coal, biomass, natural gas, etc.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: May 26, 2015
    Assignee: PIONEER ENERGY
    Inventors: John Henri, Jan Zygmunt, Mark Bergren, Robert Zubrin