Patents by Inventor Jan Zygmunt
Jan Zygmunt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20220142969Abstract: The present invention discloses the water-soluble cannabinoid-containing solid dispersion and method of preparation thereof. The solid dispersion of the invention comprises one or more cannabinoids as active ingredients, a hydrophilic polymeric carrier, an antioxidant and optionally the palatability-improving agent. The solid dispersion is suitable for oral delivery application in form of solid material or an aqueous colloidal dispersion or for transdermal delivery application.Type: ApplicationFiled: December 31, 2020Publication date: May 12, 2022Inventors: Jan ZYGMUNT, Thomas BLAKELEY
-
Publication number: 20200237708Abstract: The present invention relates to a method for the treatment of cancer in a cancer patient.Type: ApplicationFiled: April 15, 2020Publication date: July 30, 2020Inventors: Jan Zygmunt, James Ferrara, James D. McChesney
-
Patent number: 10639293Abstract: The present invention relates to a method for the treatment of cancer in a cancer patient.Type: GrantFiled: January 14, 2019Date of Patent: May 5, 2020Assignee: Tapestry Pharmaceuticals, Inc.Inventors: Jan Zygmunt, James Ferrara, James D. McChesney
-
Publication number: 20190142784Abstract: Provided herein are compounds, compositions containing the compounds, and methods for the treatment of cancer in a cancer patient. In particular, the compounds are made by a process comprising treating a first compound represented by either Formula G? or Formula M?: with a second compound of generalized formula R8R9C(OCH3)2 and an acid selected from the group consisting of camphor sulfonic acid (CSA), p-toluene sulfonic acid (PTSA), hydrochloric acid (HCl) and acetic acid (AcOH), wherein R1 and R2 are each selected from H, an alkyl group, an olefinic group, an aromatic group, an O-alkyl group, an O-olefinic group, or an O-aromatic group; R7 is an alkyl group, an olefinic group, or an aromatic group; P1 is a hydroxyl protecting group; P5 is H or an acid labile protecting group at the 7-O position; R8 is H, alkyl group, olefinic or aromatic group; and R9 is: H, alkyl group, olefinic or aromatic or is as defined in the specification.Type: ApplicationFiled: January 14, 2019Publication date: May 16, 2019Inventors: Jan Zygmunt, James Ferrara, James D. McChesney
-
Patent number: 10238621Abstract: Provided herein are compounds, compositions containing the compounds, and methods for the treatment of cancer in a cancer patient. In particular, the compounds are made by a process comprising treating a first compound represented by either Formula G? or Formula M?: with a second compound of generalized formula R8R9C(OCH3)2 and an acid selected from the group consisting of camphor sulfonic acid (CSA), p-toluene sulfonic acid (PTSA), hydrochloric acid (HCl) and acetic acid (AcOH), wherein R1 and R2 are each selected from H, an alkyl group, an olefinic group, an aromatic group, an O-alkyl group, an O-olefinic group, or an O-aromatic group; R7 is an alkyl group, an olefinic group, or an aromatic group; P1 is a hydroxyl protecting group; P5 is H or an acid labile protecting group at the 7-O position; R8 is H, alkyl group, olefinic or aromatic group; and R9 is: H, alkyl group, olefinic or aromatic or is as defined in the specification.Type: GrantFiled: October 9, 2017Date of Patent: March 26, 2019Assignee: TAPESTRY PHARMACEUTICALS, INC.Inventors: Jan Zygmunt, James Ferrara, James D. McChesney
-
Publication number: 20180125811Abstract: Provided herein are compounds, compositions containing the compounds, and methods for the treatment of cancer in a cancer patient. In particular, the compounds are made by a process comprising treating a first compound represented by either Formula G? or Formula M?: with a second compound of generalized formula R8R9C(OCH3)2 and an acid selected from the group consisting of camphor sulfonic acid (CSA), p-toluene sulfonic acid (PTSA), hydrochloric acid (HCl) and acetic acid (AcOH), wherein R1 and R2 are each selected from H, an alkyl group, an olefinic group, an aromatic group, an O-alkyl group, an O-olefinic group, or an O-aromatic group; R7 is an alkyl group, an olefinic group, or an aromatic group; P1 is a hydroxyl protecting group; P5 is H or an acid labile protecting group at the 7-O position; R8 is H, alkyl group, olefinic or aromatic group; and R9 is: H, alkyl group, olefinic or aromatic or is as defined in the specification.Type: ApplicationFiled: October 9, 2017Publication date: May 10, 2018Inventors: Jan Zygmunt, James Ferrara, James D. McChesney
-
Patent number: 9926245Abstract: Methods to synthesize fuels and chemicals from natural gas liquids are described. Higher alcohols are synthesized starting from natural gas liquid compounds by converting an alkane from a NGL to an olefin, dimerizing said olefin, and, hydrating said olefin product to form a higher alcohol. Higher alcohols are synthesized starting from natural gas liquid compounds by converting an alkane from a NGL to an olefin, oxidizing the olefin to form a ketone or aldehyde and, hydrogenating the aldehyde or ketone product to form a higher alcohol. Thus, NGL component butane may be dehydrogenated to form butane, butylene is oxidized in the presence of a catalyst to form methylethyl ketone and methylethyl ketone hydrogenated to form butanol.Type: GrantFiled: September 29, 2014Date of Patent: March 27, 2018Assignee: Pioneer EnergyInventors: John T Henri, Jan Zygmunt, Robert Zubrin
-
Patent number: 9820962Abstract: Provided herein are compounds, compositions containing the compounds, and methods for the treatment of cancer in a cancer patient. In particular, the compounds are made by a process comprising treating a first compound represented by either Formula G? or Formula M?: with a second compound of generalized formula R8R9C(OCH3)2 and an acid selected from the group consisting of camphor sulfonic acid (CSA), p-toluene sulfonic acid (PTSA), hydrochloric acid (HCl) and acetic acid (AcOH), wherein R1 and R2 are each selected from H, an alkyl group, an olefinic group, an aromatic group, an O-alkyl group, an O-olefinic group, or an O-aromatic group; R7 is an alkyl group, an olefinic group, or an aromatic group; P1 is a hydroxyl protecting group; P5 is H or an acid labile protecting group at the 7-O position; R8 is H, alkyl group, olefinic or aromatic group; and R9 is: H, alkyl group, olefinic or aromatic or is as defined in the specification.Type: GrantFiled: July 27, 2016Date of Patent: November 21, 2017Assignee: Tapestry Pharmaceuticals, Inc.Inventors: Jan Zygmunt, James Ferrara, James D. McChesney
-
Patent number: 9656932Abstract: In one embodiment, the present application discloses methods to selectively synthesize higher alcohols and hydrocarbons useful as fuels and industrial chemicals from syngas and biomass. Ketene and ketonization chemistry along with hydrogenation reactions are used to synthesize fuels and chemicals. In another embodiment, ketene used to form fuels and chemicals may be manufactured from acetic acid which in turn can be synthesized from synthesis gas which is produced from coal, biomass, natural gas, etc.Type: GrantFiled: May 12, 2015Date of Patent: May 23, 2017Assignee: PIONEER ENERGYInventors: John T. Henri, Jan Zygmunt, Mark Berggren, Robert Zubrin
-
Patent number: 9611186Abstract: In one embodiment, the present application discloses methods to selectively synthesize higher alcohols and hydrocarbons useful as fuels and industrial chemicals from syngas and biomass. Ketene and ketonization chemistry along with hydrogenation reactions are used to synthesize fuels and chemicals. In another embodiment, ketene used to form fuels and chemicals may be manufactured from acetic acid which in turn can be synthesized from synthesis gas which is produced from coal, biomass, natural gas, etc.Type: GrantFiled: November 8, 2012Date of Patent: April 4, 2017Assignee: PIONEER ENERGYInventors: John Henri, Jan Zygmunt, Mark Berggren, Robert Zubrin
-
Publication number: 20160331718Abstract: Provided herein are compounds, compositions containing the compounds, and methods for the treatment of cancer in a cancer patient. In particular, the compounds are made by a process comprising treating a first compound represented by either Formula G? or Formula M?: with a second compound of generalized formula R8R9C(OCH3)2 and an acid selected from the group consisting of camphor sulfonic acid (CSA), p-toluene sulfonic acid (PTSA), hydrochloric acid (HCl) and acetic acid (AcOH), wherein R1 and R2 are each selected from H, an alkyl group, an olefinic group, an aromatic group, an O-alkyl group, an O-olefinic group, or an O-aromatic group; R7 is an alkyl group, an olefinic group, or an aromatic group; P1 is a hydroxyl protecting group; P5 is H or an acid labile protecting group at the 7-O position; R8 is H, alkyl group, olefinic or aromatic group; and R9 is: H, alkyl group, olefinic or aromatic or is as defined in the specification.Type: ApplicationFiled: July 27, 2016Publication date: November 17, 2016Inventors: Jan ZYGMUNT, James FERRARA, James D. McCHESNEY
-
Patent number: 9440898Abstract: In one embodiment, the present application discloses methods to selectively synthesize higher alcohols and hydrocarbons useful as fuels and industrial chemicals from syngas and biomass. Ketene and ketonization chemistry along with hydrogenation reactions are used to synthesize fuels and chemicals. In another embodiment, ketene used to form fuels and chemicals may be manufactured from acetic acid which in turn can be synthesized from synthesis gas which is produced from coal, biomass, natural gas, etc.Type: GrantFiled: July 30, 2015Date of Patent: September 13, 2016Assignee: PIONEER ENERGYInventors: John T. Henri, Jan Zygmunt, Mark Berggren, Robert Zubrin
-
Patent number: 9402824Abstract: Provided herein are compounds, compositions containing the compounds, and methods for the treatment of cancer in a cancer patient. In particular, the compounds are made by a process comprising treating a first compound represented by either Formula G? or Formula M?: with a second compound of generalized formula R8R9C(OCH3)2 and an acid selected from the group consisting of camphor sulfonic acid (CSA), p-toluene sulfonic acid (PTSA), hydrochloric acid (HCl) and acetic acid (AcOH), wherein R1 and R2 are each selected from H, an alkyl group, an olefinic group, an aromatic group, an O-alkyl group, an O-olefinic group, or an O-aromatic group; R7 is an alkyl group, an olefinic group, or an aromatic group; P1 is a hydroxyl protecting group; P5 is H or an acid labile protecting group at the 7-O position; R8 is H, alkyl group, olefinic or aromatic group; and R9 is: H, alkyl group, olefinic or aromatic or is as defined in the specification.Type: GrantFiled: January 23, 2015Date of Patent: August 2, 2016Assignee: Tapestry Pharmaceuticals, Inc.Inventors: Jan Zygmunt, James Ferrara, James D. McChesney
-
Publication number: 20160200645Abstract: Methods to synthesize fuels and chemicals from natural gas liquids are described. Higher alcohols are synthesized starting from natural gas liquid compounds by converting an alkane from a NGL to an olefin, dimerizing said olefin, and, hydrating said olefin product to form a higher alcohol. Higher alcohols are synthesized starting from natural gas liquid compounds by converting an alkane from a NGL to an olefin, oxidizing the olefin to form a ketone or aldehyde and, hydrogenating the aldehyde or ketone product to form a higher alcohol. Thus, NGL component butane may be dehydrogenated to form butane, butylene is oxidized in the presence of a catalyst to form methylethyl ketone and methylethyl ketone hydrogenated to form butanol.Type: ApplicationFiled: September 29, 2014Publication date: July 14, 2016Applicant: PIONEER ENERGY INCInventors: John T Henri, Jan Zygmunt, Robert Zubrin
-
Publication number: 20160031776Abstract: In one embodiment, the present application discloses methods to selectively synthesize higher alcohols and hydrocarbons useful as fuels and industrial chemicals from syngas and biomass. Ketene and ketonization chemistry along with hydrogenation reactions are used to synthesize fuels and chemicals. In another embodiment, ketene used to form fuels and chemicals may be manufactured from acetic acid which in turn can be synthesized from synthesis gas which is produced from coal, biomass, natural gas, etc.Type: ApplicationFiled: July 30, 2015Publication date: February 4, 2016Applicant: Pioneer Energy, Inc.Inventors: John T. Henri, Jan Zygmunt, Mark Berggren, Robert Zubrin
-
Publication number: 20150353854Abstract: Methods to synthesize useful alcohol and aromatic hydrocarbon products from sorbitol derived from sugars are described. Sorbitol is dehydrated to form furans such as 2-acetylfuran which is hydrogenated to form hexanols, ethyl tetrahydrofuran, etc useful as fuels and chemicals for industry and commerce. Sorbitol may also be heated over a dehydrating catalyst to form aromatic hydrocarbons useful as fuels.Type: ApplicationFiled: June 9, 2014Publication date: December 10, 2015Applicant: PIONEER ENERGY INCInventors: John T Henri, Jan Zygmunt, Robert Zubrin
-
Publication number: 20150267135Abstract: In one embodiment, the present application discloses methods to selectively synthesize higher alcohols and hydrocarbons useful as fuels and industrial chemicals from syngas and biomass. Ketene and ketonization chemistry along with hydrogenation reactions are used to synthesize fuels and chemicals. In another embodiment, ketene used to form fuels and chemicals may be manufactured from acetic acid which in turn can be synthesized from synthesis gas which is produced from coal, biomass, natural gas, etc.Type: ApplicationFiled: April 23, 2015Publication date: September 24, 2015Applicant: Pioneer Energy, Inc.Inventors: John Henri, Jan Zygmunt, Mark Berggren, Robert Zubrin
-
Publication number: 20150246862Abstract: In one embodiment, the present application discloses methods to selectively synthesize higher alcohols and hydrocarbons useful as fuels and industrial chemicals from syngas and biomass. Ketene and ketonization chemistry along with hydrogenation reactions are used to synthesize fuels and chemicals. In another embodiment, ketene used to form fuels and chemicals may be manufactured from acetic acid which in turn can be synthesized from synthesis gas which is produced from coal, biomass, natural gas, etc.Type: ApplicationFiled: May 12, 2015Publication date: September 3, 2015Applicant: Pioneer Energy, Inc.Inventors: John T. Henri, Jan Zygmunt, Mark Berggren, Robert Zubrin
-
Synthesis of high caloric fuels and chemicals including pentanol from coal, natural gas, and biomass
Patent number: 9080119Abstract: In one embodiment, the present application discloses methods to selectively synthesize higher alcohols and hydrocarbons useful as fuels and industrial chemicals from syngas and biomass. Ketene and ketonization chemistry along with hydrogenation reactions are used to synthesize fuels and chemicals. In another embodiment, ketene used to form fuels and chemicals may be manufactured from acetic acid which in turn can be synthesized from synthesis gas which is produced from coal, biomass, natural gas, etc.Type: GrantFiled: March 20, 2013Date of Patent: July 14, 2015Assignee: PIONEER ENERGYInventors: John Henri, Jan Zygmunt, Mark Berggren, Robert Zubrin -
Patent number: 9040757Abstract: In one embodiment, the present application discloses methods to selectively synthesize higher alcohols and hydrocarbons useful as fuels and industrial chemicals from syngas and biomass. Ketene and ketonization chemistry along with hydrogenation reactions are used to synthesize fuels and chemicals. In another embodiment, ketene used to form fuels and chemicals may be manufactured from acetic acid which in turn can be synthesized from synthesis gas which is produced from coal, biomass, natural gas, etc.Type: GrantFiled: March 8, 2013Date of Patent: May 26, 2015Assignee: PIONEER ENERGYInventors: John Henri, Jan Zygmunt, Mark Bergren, Robert Zubrin