Patents by Inventor Jana Kralovicova

Jana Kralovicova has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Reducing intron retention
    Patent number: 11891605
    Abstract: Disclosed herein are methods, compositions, polynucleic acid polymers, assays, and kits for inducing processing of a partially processed mRNA transcript to remove a retained intron to produce a fully processed mRNA transcript that encodes a full-length functional form of a protein. Also described herein are methods and compositions for treating a disease or condition characterized by impaired production of a full-length functional form of a protein or for treating a disease or condition characterized by a defective splicing in a subject.
    Type: Grant
    Filed: June 22, 2022
    Date of Patent: February 6, 2024
    Assignee: University of Southampton
    Inventors: Igor Vorechovsky, Jana Kralovicova
  • MODULATION OF GENE EXPRESSION AND SCREENING FOR DEREGULATED PROTEIN EXPRESSION
    Publication number: 20230416756
    Abstract: Disclosed herein include compositions and methods of modulating protein expression that utilizes an activator or a repressor of a non-sense mediated RNA decay switch exon (NSE). In some embodiments, also included herein are compositions and methods of modulating protein expression that uses an agent that targets a transposed element.
    Type: Application
    Filed: April 12, 2023
    Publication date: December 28, 2023
    Inventors: Igor VORECHOVSKY, Jana KRALOVICOVA
  • Modulation of gene expression and screening for deregulated protein expression
    Patent number: 11702660
    Abstract: Disclosed herein include compositions and methods of modulating protein expression that utilizes an activator or a repressor of a non-sense mediated RNA decay switch exon (NSE). In some embodiments, also included herein are compositions and methods of modulating protein expression that uses an agent that targets a transposed element.
    Type: Grant
    Filed: January 27, 2021
    Date of Patent: July 18, 2023
    Assignee: University of Southampton
    Inventors: Igor Vorechovsky, Jana Kralovicova
  • REDUCING INTRON RETENTION
    Publication number: 20230183693
    Abstract: Disclosed herein are methods, compositions, polynucleic acid polymers, assays, and kits for inducing processing of a partially processed mRNA transcript to remove a retained intron to produce a fully processed mRNA transcript that encodes a full-length functional form of a protein. Also described herein are methods and compositions for treating a disease or condition characterized by impaired production of a full-length functional form of a protein or for treating a disease or condition characterized by a defective splicing in a subject.
    Type: Application
    Filed: June 22, 2022
    Publication date: June 15, 2023
    Inventors: Igor Vorechovsky, Jana Kralovicova
  • Reducing intron retention
    Patent number: 11390869
    Abstract: Disclosed herein are methods, compositions, polynucleic acid polymers, assays, and kits for inducing processing of a partially processed mRNA transcript to remove a retained intron to produce a fully processed mRNA transcript that encodes a full-length functional form of a protein. Also described herein are methods and compositions for treating a disease or condition characterized by impaired production of a full-length functional form of a protein or for treating a disease or condition characterized by a defective splicing in a subject.
    Type: Grant
    Filed: November 26, 2019
    Date of Patent: July 19, 2022
    Assignee: University of Southampton
    Inventors: Igor Vorechovsky, Jana Kralovicova
  • MODULATION OF GENE EXPRESSION AND SCREENING FOR DEREGULATED PROTEIN EXPRESSION
    Publication number: 20210155936
    Abstract: Disclosed herein include compositions and methods of modulating protein expression that utilizes an activator or a repressor of a non-sense mediated RNA decay switch exon (NSE). In some embodiments, also included herein are compositions and methods of modulating protein expression that uses an agent that targets a transposed element.
    Type: Application
    Filed: January 27, 2021
    Publication date: May 27, 2021
    Inventors: Igor VORECHOVSKY, Jana KRALOVICOVA
  • Modulation of gene expression and screening for deregulated protein expression
    Patent number: 10941405
    Abstract: Disclosed herein include compositions and methods of modulating protein expression that utilizes an activator or a repressor of a non-sense mediated RNA decay switch exon (NSE). In some embodiments, also included herein are compositions and methods of modulating protein expression that uses an agent that targets a transposed element.
    Type: Grant
    Filed: December 7, 2018
    Date of Patent: March 9, 2021
    Assignee: University of Southampton
    Inventors: Igor Vorechovsky, Jana Kralovicova
  • REDUCING INTRON RETENTION
    Publication number: 20200231969
    Abstract: Disclosed herein are methods, compositions, polynucleic acid polymers, assays, and kits for inducing processing of a partially processed mRNA transcript to remove a retained intron to produce a fully processed mRNA transcript that encodes a full-length functional form of a protein. Also described herein are methods and compositions for treating a disease or condition characterized by impaired production of a full-length functional form of a protein or for treating a disease or condition characterized by a defective splicing in a subject.
    Type: Application
    Filed: November 26, 2019
    Publication date: July 23, 2020
    Inventors: Igor Vorechovsky, Jana Kralovicova
  • Reducing intron retention
    Patent number: 10538764
    Abstract: Disclosed herein are methods, compositions, polynucleic acid polymers, assays, and kits for inducing processing of a partially processed mRNA transcript to remove a retained intron to produce a fully processed mRNA transcript that encodes a full-length functional form of a protein. Also described herein are methods and compositions for treating a disease or condition characterized by impaired production of a full-length functional form of a protein or for treating a disease or condition characterized by a defective splicing in a subject.
    Type: Grant
    Filed: June 12, 2017
    Date of Patent: January 21, 2020
    Assignee: University of Southampton
    Inventors: Igor Vorechovsky, Jana Kralovicova
  • MODULATION OF GENE EXPRESSION AND SCREENING FOR DEREGULATED PROTEIN EXPRESSION
    Publication number: 20190264211
    Abstract: Disclosed herein include compositions and methods of modulating protein expression that utilizes an activator or a repressor of a non-sense mediated RNA decay switch exon (NSE). In some embodiments, also included herein are compositions and methods of modulating protein expression that uses an agent that targets a transposed element.
    Type: Application
    Filed: December 7, 2018
    Publication date: August 29, 2019
    Inventors: Igor Vorechovsky, Jana Kralovicova
  • Modulation of gene expression and screening for deregulated protein expression
    Patent number: 10196639
    Abstract: Disclosed herein include compositions and methods of modulating protein expression that utilizes an activator or a repressor of a non-sense mediated RNA decay switch exon (NSE). In some embodiments, also included herein are compositions and methods of modulating protein expression that uses an agent that targets a transposed element.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: February 5, 2019
    Assignee: University of Southampton
    Inventors: Igor Vorechovsky, Jana Kralovicova
  • REDUCING INTRON RETENTION
    Publication number: 20180002694
    Abstract: Disclosed herein are methods, compositions, polynucleic acid polymers, assays, and kits for inducing processing of a partially processed mRNA transcript to remove a retained intron to produce a fully processed mRNA transcript that encodes a full-length functional form of a protein. Also described herein are methods and compositions for treating a disease or condition characterized by impaired production of a full-length functional form of a protein or for treating a disease or condition characterized by a defective splicing in a subject.
    Type: Application
    Filed: June 12, 2017
    Publication date: January 4, 2018
    Inventors: Igor Vorechovsky, Jana Kralovicova
  • Reducing intron retention
    Patent number: 9745577
    Abstract: Disclosed herein are methods, compositions, polynucleic acid polymers, assays, and kits for inducing processing of a partially processed mRNA transcript to remove a retained intron to produce a fully processed mRNA transcript that encodes a full-length functional form of a protein. Also described herein are methods and compositions for treating a disease or condition characterized by impaired production of a full-length functional form of a protein or for treating a disease or condition characterized by a defective splicing in a subject.
    Type: Grant
    Filed: June 16, 2015
    Date of Patent: August 29, 2017
    Assignee: UNIVERSITY OF SOUTHAMPTON
    Inventors: Igor Vorechovsky, Jana Kralovicova
  • Reducing intron retention
    Patent number: 9714422
    Abstract: Disclosed herein are methods, compositions, polynucleic acid polymers, assays, and kits for inducing processing of a partially processed mRNA transcript to remove a retained intron to produce a fully processed mRNA transcript that encodes a full-length functional form of a protein. Also described herein are methods and compositions for treating a disease or condition characterized by impaired production of a full-length functional form of a protein or for treating a disease or condition characterized by a defective splicing in a subject.
    Type: Grant
    Filed: May 6, 2016
    Date of Patent: July 25, 2017
    Assignee: UNIVERSITY OF SOUTHAMPTON
    Inventors: Igor Vorechovsky, Jana Kralovicova
  • MODULATION OF GENE EXPRESSION AND SCREENING FOR DEREGULATED PROTEIN EXPRESSION
    Publication number: 20170101641
    Abstract: Disclosed herein include compositions and methods of modulating protein expression that utilizes an activator or a repressor of a non-sense mediated RNA decay switch exon (NSE). In some embodiments, also included herein are compositions and methods of modulating protein expression that uses an agent that targets a transposed element.
    Type: Application
    Filed: October 7, 2016
    Publication date: April 13, 2017
    Inventors: Igor Vorechovsky, Jana Kralovicova
  • REDUCING INTRON RETENTION
    Publication number: 20160244762
    Abstract: Disclosed herein are methods, compositions, polynucleic acid polymers, assays, and kits for inducing processing of a partially processed mRNA transcript to remove a retained intron to produce a fully processed mRNA transcript that encodes a full-length functional form of a protein. Also described herein are methods and compositions for treating a disease or condition characterized by impaired production of a full-length functional form of a protein or for treating a disease or condition characterized by a defective splicing in a subject.
    Type: Application
    Filed: May 6, 2016
    Publication date: August 25, 2016
    Inventors: Igor Vorechovsky, Jana Kralovicova
  • REDUCING INTRON RETENTION
    Publication number: 20160017322
    Abstract: Disclosed herein are methods, compositions, polynucleic acid polymers, assays, and kits for inducing processing of a partially processed mRNA transcript to remove a retained intron to produce a fully processed mRNA transcript that encodes a full-length functional form of a protein. Also described herein are methods and compositions for treating a disease or condition characterized by impaired production of a full-length functional form of a protein or for treating a disease or condition characterized by a defective splicing in a subject.
    Type: Application
    Filed: June 16, 2015
    Publication date: January 21, 2016
    Inventors: Igor Vorechovsky, Jana Kralovicova