Abstract: Identification of molecules which modulate inter alia obesity, anorexia, weight maintenance, inflammation and/or metabolic energy levels in a subject are described which particularly relate to a protein molecule called “FIT”, previously known as “AGT-121”. Ligands of “FIT” as well as antagonists of “FIT”-ligand interaction are proposed to modulate inter alia obesity, anorexia, weight maintenance, inflammation and/or metabolic energy levels in a subject. Methods of treatment and prophylaxis and pharmaceutical compositions useful in modulating inter alia obesity, anorexia, weight maintenance, inflammation and/or metabolic energy levels are also provided.

Abstract: The present invention relates generally to a method of modulating the functional activity of a serum amyloid A or derivative, homologue, analogue, equivalent or mimetic thereof and, more particularly, to a method of modulating the functional activity of a serum amyloid A by modulating intracellular levels of Tanis or derivative, homologue, analogue, chemical equivalent or mimetic thereof. The method of the present invention is particularly useful, inter alia, in the treatment and/or prophylaxis of conditions characterised by aberrant, unwanted or otherwise inappropriate serum amyloid A activity. The present invention is further directed to methods for identifying and/or designing agents capable of modulating Tanis mediated regulation of a serum amyloid A functional activity.