Patents by Inventor Jannis Stavrianopoulos
Jannis Stavrianopoulos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11028121Abstract: Provided are compounds comprising two DNA supramolecular binding molecules covalently joined by a linker group. Also provided are multisignal labeling reagents comprising (i) an oligomer of nucleotides or nucleotide analogs; (ii) a DNA supramolecular binding molecule noncovalently bound to the oligomer; and (iii) a first reactive group or a first partner of a first binding pair covalently bound to the oligomer. Additionally provided are methods of producing multisignal labeling reagents.Type: GrantFiled: March 26, 2020Date of Patent: June 8, 2021Assignee: ENZO LIFE SCIENCES, INC.Inventors: Jack Coleman, Elazar Rabbani, Jannis Stavrianopoulos, Praveen Pande
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Publication number: 20200270297Abstract: Provided are compounds comprising two DNA supramolecular binding molecules covalently joined by a linker group. Also provided are multisignal labeling reagents comprising (i) an oligomer of nucleotides or nucleotide analogs; (ii) a DNA supramolecular binding molecule noncovalently bound to the oligomer; and (iii) a first reactive group or a first partner of a first binding pair covalently bound to the oligomer. Additionally provided are methods of producing multisignal labeling reagents.Type: ApplicationFiled: March 26, 2020Publication date: August 27, 2020Applicant: Enzo Life Science, Inc.Inventors: Jack Coleman, Elazar Rabbani, Jannis Stavrianopoulos, Praveen Pande
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Patent number: 10647740Abstract: Provided are compounds comprising two DNA supramolecular binding molecules covalently joined by a linker group. Also provided are multisignal labeling reagents comprising (i) an oligomer of nucleotides or nucleotide analogs; (ii) a DNA supramolecular binding molecule noncovalently bound to the oligomer; and (iii) a first reactive group or a first partner of a first binding pair covalently bound to the oligomer. Additionally provided are methods of producing multisignal labeling reagents.Type: GrantFiled: December 21, 2017Date of Patent: May 12, 2020Assignee: Enzo Life Science, Inc.Inventors: Jack Coleman, Elazar Rabbani, Jannis Stavrianopoulos, Praveen Pande
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Patent number: 10640529Abstract: Provided are compounds comprising two DNA supramolecular binding molecules covalently joined by a linker group. Also provided are multisignal labeling reagents comprising (i) an oligomer of nucleotides or nucleotide analogs; (ii) a DNA supramolecular binding molecule noncovalently bound to the oligomer; and (iii) a first reactive group or a first partner of a first binding pair covalently bound to the oligomer. Additionally provided are methods of producing multisignal labeling reagents.Type: GrantFiled: December 21, 2017Date of Patent: May 5, 2020Assignee: Enzo Life Sciences, Inc.Inventors: Jack Coleman, Elazar Rabbani, Jannis Stavrianopoulos, Praveen Pande
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Publication number: 20180127455Abstract: Provided are compounds comprising two DNA supramolecular binding molecules covalently joined by a linker group. Also provided are multisignal labeling reagents comprising (i) an oligomer of nucleotides or nucleotide analogs; (ii) a DNA supramolecular binding molecule noncovalently bound to the oligomer; and (iii) a first reactive group or a first partner of a first binding pair covalently bound to the oligomer. Additionally provided are methods of producing multisignal labeling reagents.Type: ApplicationFiled: December 21, 2017Publication date: May 10, 2018Applicant: Enzo Life Science, Inc., c/o Enzo Biochem, Inc.Inventors: Jack Coleman, Elazar Rabbani, Jannis Stavrianopoulos, Praveen Pande
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Publication number: 20180127456Abstract: Provided are compounds comprising two DNA supramolecular binding molecules covalently joined by a linker group. Also provided are multisignal labeling reagents comprising (i) an oligomer of nucleotides or nucleotide analogs; (ii) a DNA supramolecular binding molecule noncovalently bound to the oligomer; and (iii) a first reactive group or a first partner of a first binding pair covalently bound to the oligomer. Additionally provided are methods of producing multisignal labeling reagents.Type: ApplicationFiled: December 21, 2017Publication date: May 10, 2018Applicant: Enzo Life Science, Inc., c/o Enzo Biochem, Inc.Inventors: Jack Coleman, Elazar Rabbani, Jannis Stavrianopoulos, Praveen Pande
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Patent number: 9884889Abstract: Provided are compounds comprising two DNA supramolecular binding molecules covalently joined by a linker group. Also provided are multisignal labeling reagents comprising (i) an oligomer of nucleotides or nucleotide analogs; (ii) a DNA supramolecular binding molecule noncovalently bound to the oligomer; and (iii) a first reactive group or a first partner of a first binding pair covalently bound to the oligomer. Additionally provided are methods of producing multisignal labeling reagents.Type: GrantFiled: September 3, 2015Date of Patent: February 6, 2018Assignee: Enzo Life Sciences, Inc.Inventors: Jack Coleman, Elazar Rabbani, Jannis Stavrianopoulos, Praveen Pande
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Publication number: 20160025716Abstract: Provided are compounds comprising two DNA supramolecular binding molecules covalently joined by a linker group. Also provided are multisignal labeling reagents comprising (i) an oligomer of nucleotides or nucleotide analogs; (ii) a DNA supramolecular binding molecule noncovalently bound to the oligomer; and (iii) a first reactive group or a first partner of a first binding pair covalently bound to the oligomer. Additionally provided are methods of producing multisignal labeling reagents.Type: ApplicationFiled: September 3, 2015Publication date: January 28, 2016Applicant: Enzo Life Science, Inc., c/o Enzo Biochem, Inc.Inventors: Jack Coleman, Elazar Rabbani, Jannis Stavrianopoulos, Praveen Pande
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Patent number: 9156986Abstract: Provided are compounds comprising two DNA supramolecular binding molecules covalently joined by a linker group. Also provided are multisignal labeling reagents comprising (i) an oligomer of nucleotides or nucleotide analogs; (ii) a DNA supramolecular binding molecule noncovalently bound to the oligomer; and (iii) a first reactive group or a first partner of a first binding pair covalently bound to the oligomer. Additionally provided are methods of producing multisignal labeling reagents.Type: GrantFiled: March 14, 2011Date of Patent: October 13, 2015Assignee: Enzo Life Sciences, Inc.Inventors: Jack Coleman, Elazar Rabbani, Jannis Stavrianopoulos, Praveen Pande
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Patent number: 8445664Abstract: This invention provides novel processes for amplifying nucleic acid sequences of interest, including linear and non-linear amplification. In linear amplification, a single initial primer or nucleic acid construct is utilized to carry out the amplification process. In non-linear amplification, a first initial primer or nucleic acid construct is employed with a subsequent initial primer or nucleic acid construct. In other non-linear amplification processes provided by this invention, a first initial primer or nucleic acid construct is deployed with a second initial primer or nucleic acid construct to amplify the specific nucleic acid sequence of interest and its complement that are provided. A singular primer or a singular nucleic acid construct capable of non-linear amplification can also be used to carry out non-linear amplification in accordance with this invention.Type: GrantFiled: October 20, 2005Date of Patent: May 21, 2013Assignee: Enzo Diagnostics, Inc.Inventors: Elazar Rabbani, Jannis Stavrianopoulos, James J. Donegan, Jack Coleman, Marleen Walner
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Patent number: 8334370Abstract: Provided are nucleic acid compositions modified with intercalating aromatic compounds attached directly or indirectly through a linker arm thereto. Modifications to the nucleotides or to the oligo- or polynucleotides involve the pentosyl moieties, the abasic moieties (without a base) and the base moieties. Useful property changes are effected and can be measured or detected when such modified nucleic acids compositions have hybridized specifically to target nucleic acids.Type: GrantFiled: October 5, 1992Date of Patent: December 18, 2012Assignee: Enzo Biochem, Inc.Inventors: Jannis Stavrianopoulos, Elazar Rabbani
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Publication number: 20110318788Abstract: Provided are compounds comprising two DNA supramolecular binding molecules covalently joined by a linker group. Also provided are multisignal labeling reagents comprising (i) an oligomer of nucleotides or nucleotide analogs; (ii) a DNA supramolecular binding molecule noncovalently bound to the oligomer; and (iii) a first reactive group or a first partner of a first binding pair covalently bound to the oligomer. Additionally provided are methods of producing multisignal labeling reagents.Type: ApplicationFiled: March 14, 2011Publication date: December 29, 2011Applicant: ENZO LIFE SCIENCES, INC., C/O ENZO BIOCHEM, INC.Inventors: Jack Coleman, Elazar Rabbani, Jannis Stavrianopoulos, Praveen Pande
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Publication number: 20100273145Abstract: A method of detecting in a sample an analyte (A) having a molecularly recognizable portion thereon, which comprises: providing (B) a molecular bridging entity having thereon: (i) a portion capable of recognizing the molecularly recognizable portion on the analyte; and (ii) a portion comprising a polynucleotide sequence; and (C) a signalling entity having thereon: (i) a polynucleotide portion capable of annealing to the polynucleotide portion of the bridging entity, thereby to form a stable polynucleotide hybrid, and (ii) a signal generating portion; forming a complex comprising: (1) the analyte (A) complexed through its molecularly recognizable portion to (2) the recognizing portion of the entity (B); the entity (B) being complexed through the polynucleotide portion thereon to (3) the polynucleotide portion of the signalling entity; and detecting a signal by means of the signal generating portion present in the complex.Type: ApplicationFiled: June 7, 1995Publication date: October 28, 2010Applicant: ENZO BIOCHEM, INC.Inventors: ROBERT PERGOLIZZI, JANNIS STAVRIANOPOULOS, ELAZAR RABBANI, DEAN ENGELHARDT, STAN KLINE, PAULA OLSIEWSKI
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Publication number: 20080108139Abstract: The present invention provides an array of compositions useful for effecting and/or exhibiting changes in biological functioning and processing within cells and in biological systems containing such cells. In effect, these compositions combine chemical modifications and/or ligand additions with biological functions. The chemical modifications and/or ligand additions provide additional characteristics to the compositions without interfering substantially with their biological function. Such additional characteristics include nuclease resistance, targeting specific cells or specific cell receptors localizing to specific sites within cells and augmenting interactions between the compositions and target cells of interest as well as decreasing such interactions when desired. Also provided by the present invention are processes and kits.Type: ApplicationFiled: October 30, 2007Publication date: May 8, 2008Applicant: Enzo Therapeutics, Inc.Inventors: Elazar Rabbani, Jannis Stavrianopoulos, James Donegan, Dakai Liu, Norman Kelker, Dean Engelhardt
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Publication number: 20080026372Abstract: This invention provides inter alia an in vitro process for producing multiple specific nucleic acid copies in which the copies are produced under isostatic conditions, e.g., temperature, buffer and ionic strength, and independently of any requirement for introducing an intermediate structure for producing the copies. In other aspects, the invention provides in vitro processes for producing multiple specific nucleic acid copies in which the products are substantially free of any primer-coded sequences, such sequences having been substantially or all removed from the product to regenerate a primer binding site, thereby allowing new priming events to occur and multiple nucleic acid copies to be produced. This invention further provides a promoter-independent non-naturally occurring nucleic acid construct that produces a nucleic acid copy or copies without using or relying on any gene product that may be coded by the nucleic acid construct.Type: ApplicationFiled: November 19, 2003Publication date: January 31, 2008Applicant: Enzo Diagnostics, Inc.Inventors: Dean Engelhardt, Jannis Stavrianopoulos, Elazar Rabbani, James Donegan
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Publication number: 20070196828Abstract: This invention provides novel compositions and processes for analyte detection, quantification and amplification. Nucleic acid arrays and libraries of analytes are usefully incorporated into such compositions and processes. Universal detection elements, signaling entities and the like are employed to detect and if necessary or desirable, to quantify analytes. Amplification of target analytes are also provided by the compositions and processes of this invention.Type: ApplicationFiled: July 27, 2004Publication date: August 23, 2007Applicant: Enzo Life Sciences, Inc.Inventors: Elazar Rabbani, Jannis Stavrianopoulos, James Donegan, Jack Coleman
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Publication number: 20060172310Abstract: This invention provides novel compositions and processes for analyte detection, quantification and amplification. Nucleic acid arrays and libraries of analytes are usefully incorporated into such compositions and processes. Universal detection elements, signaling entities and the like are employed to detect and if necessary or desirable, to quantify analytes. Amplification of target analytes are also provided by the compositions and processes of this invention.Type: ApplicationFiled: July 27, 2004Publication date: August 3, 2006Applicant: Enzo Life Sciences, Inc., c/o Enzo Biochem, Inc.Inventors: Elazar Rabbani, Jannis Stavrianopoulos, James Donegan, Jack Coleman
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Publication number: 20060172308Abstract: This invention provides for labeling reagents, labeled targets and processes for preparing labeling reagents. The labeling reagents can take the form of cyanine dyes, xanthene dyes, porphyrin dyes, coumarin dyes or composite dyes. These labeling reagents are useful for labeling probes or targets, including nucleic acids and proteins. These reagents can be usefully applied to protein and nucleic acid probe based assays. They are also applicable to real-time detection processes.Type: ApplicationFiled: January 22, 2004Publication date: August 3, 2006Applicant: Enzo Life Sciences, Inc., c/o Enzo Biochem, Inc.Inventors: Jannis Stavrianopoulos, Elazar Rabbani
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Publication number: 20060099601Abstract: This invention provides novel compositions and processes for analyte detection, quantification and amplification. Nucleic acid arrays and libraries of analytes are usefully incorporated into such compositions and processes. Universal detection elements, signaling entities and the like are employed to detect and if necessary or desirable, to quantify analytes. Amplification of target analytes are also provided by the compositions and processes of this invention.Type: ApplicationFiled: July 27, 2004Publication date: May 11, 2006Applicant: Enzo Life Sciences, Inc.,Inventors: Elazar Rabbani, Jannis Stavrianopoulos, James Donegan, Jack Coleman
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Publication number: 20060057583Abstract: This invention relates to novel compositions and methods for controlling the extendability of various components used in copying or amplification steps to provide an enhancement of the specificity of the nucleic acids produced by these processes as well as potentially increasing the amount of such products. By these means, the copying or amplification of target nucleic nucleic acids can be carried out under conditions where synthesis (derived from target nucleic acid templates) is retained while potentially deleterious side reactions caused by nucleic acids acting inappropriately as either primers or as templates are avoided.Type: ApplicationFiled: October 24, 2003Publication date: March 16, 2006Inventors: Elazar Rabbani, Jannis Stavrianopoulos, James Donegan, Jack Coleman