Patents by Inventor Janos Borvendeg
Janos Borvendeg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4806685Abstract: A novel 1,1,2-triphenylpropene derivative, namely: ##STR1## acts on the endocrine system of rats. It exerts oestrogenic or antioestrogenic effects of varying strength in rats, and furthermore inhibits the growth of the mammary tumor induced by 7,12-dimethyl-benz(a)anthracene in rats.Type: GrantFiled: January 31, 1986Date of Patent: February 21, 1989Assignee: Gyogyszerkutato Inteezet/Pharmaceutical Research InstituteInventors: Gizella Abraham, Tibor Horvath, Lajos Toldy, Janos Borvendeg, Endre Csanyi, Eva Kiss, Ilona S. nee Hermann, Kalman Tory
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Patent number: 4579954Abstract: The invention relates to the new monohydrate of N-methyl-N'-{2-[(5-methylimidazol-4-yl)-methylthio]-ethyl}-N"-cyanoguanidi ne (cimetidine), a histamine-H.sub.2 receptor antagonist which is called N-methyl-N'-{2-[(5-methylimidazol-4-yl)-methylthio]-ethyl}-N"-cyanoguanidi ne H (cimetidine H) as well as to a process for the preparation of same, which comprises pouring a hot, homogeneous aqueous solution of N-methyl-N'-{2-[(5-methylimidazol-4-yl)-methylthio]-ethyl}-N"-cyanoguanidi ne, optionally containing also methylamine, onto ice and separating the N-methyl-N'-{2-[(5-methylimidazol-4-yl)-methylthio]-ethyl}-N"-cyanoguanidi ne monohydrate.Type: GrantFiled: April 27, 1984Date of Patent: April 1, 1986Assignee: Richter Gedeon Vegyeszeti Gyar Rt.Inventors: Kalman Harsanyi, Gyorgy Domany, Oszkar Fuchs, Lajos Toldy, Gyorgy Fekete, Endre Kasztreiner, Bela Hegedus, Ferenc Morasz, Andras Rado, Tibor Lang, Arpad Lazar, Eva Csongor, Tibor Balogh, Janos Borvendeg, Jozsef Reiter, Tibor Somogyi, Margit Bidlo nee Igloy
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Patent number: 4539199Abstract: Pharmaceutical compositions for sustained release of pharmaceutical compounds comprising a reaction product of a water soluble salt of a pharmaceutically active compound containing a primary, secondary or tertiary amino group, and an alkali or ammonium salt of a synthetic copolymer containing an acid group, and selected from the group consisting of methacrylic acid/methacrylic acid methyl ester, methacrylic acid/acrylic acid methyl ester and methacrylic acid/acrylic acid methyl ester/methacrylic acid methyl ester copolymers and a pharmaceutically acceptable excipient. The water soluble salt of a pharmaceutically active compound containing a primary, secondary or tertiary amino group is reacted in aqueous medium with an alkali or ammonium salt of a copolymer selected from the group consisting of the above mentioned copolymers, and the resulting product is converted into a pharmaceutical composition.Type: GrantFiled: June 1, 1982Date of Patent: September 3, 1985Assignee: Egyt Gyogyszervegyeszeti GyarInventors: Erno Orban, Janos Borvendeg, Laszlo Nagy, Marta Sotinee Tolvay, Erzsebet Bander
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Patent number: 4418205Abstract: The invention relates to new 16-amino-18,19,20-trinor-prostaglandin derivatives of general formula I, having at C-17 a substituted or unsubstituted phenyl group, wherein C-15 and C-16 may have either S or R configuration, Y stands for a hydrogen atom or a lower alkyl group, W stands for a hydrogen atom, halogen atom, hydroxy group, lower alkyl or alkoxy group, and their acid addition salts. These compounds can be prepared by removing the ester group and the p-nitrobenzyloxycarbonyl protective group of a 9.alpha.,11.alpha.Type: GrantFiled: December 9, 1981Date of Patent: November 29, 1983Assignee: Patentbureau DanubiaInventors: Eva Toth-Sarudy, Gabor Ambrus, Gyorgy Cseh, Janos Borvendeg, Imre Moravcsik, Gabriella Mezei
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Patent number: 4342754Abstract: New steroid-spiro-oxathiazolidine derivatives pharmaceutical compositions containing the same, and to a process for the preparation thereof are disclosed.The new compounds have antimineral corticoide effects and have the following formula (I), ##STR1## wherein R.sub.1 is a C.sub.1-3 alkyl or a C.sub.2-4 alkenyl group, andZ is a group of the formulae (II) to (VI), ##STR2## wherein R.sub.2 is methyl or ethyl,R.sub.3 is hydrogen or methylR.sub.4 is hydrogen, a C.sub.1-3 alkyl group, a di-(C.sub.1-4 alkyl)-amino-C.sub.1-4 alkyl group, a C.sub.2-4 alkylcarbonyl group, a C.sub.2-4 alkoxycarbonyl group or a C.sub.3-6 carboxyalkylcarbonyl group, andthe dotted lines may represent additional valence bonds, with the proviso that if Z is a group of the formula (VI), a double bond exists between the carbon atoms in positions 4 and 5 or 5 and 6, andif R.sub.4 is a di-(C.sub.1-4 alkyl)-amino-C.sub.1-4 alkyl group or a C.sub.3-6 carboxyalkylcarbonyl group, the compounds may also be formed as their salts.Type: GrantFiled: March 11, 1981Date of Patent: August 3, 1982Assignee: Richter Gedeon Vegyeszeti Gyar RTInventors: Sandor Solyom, Katalin Szilagyi nee Farago, Lajos Toldi, Inge Schafer, Eleonora Szondy, Janos Borvendeg, Ilona Hermann nee Szente
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Patent number: 4328221Abstract: Compounds of the formula (I) having aldosterone-antagonizing activity are disclosed ##STR1## wherein R.sub.3 and R.sub.4 are each C.sub.1 to C.sub.3 alkyl; andZ is one of the following groups ##STR2## wherein R.sub.1 is hydrogen or methyl;R.sub.6 is hydrogen, C.sub.1 to C.sub.3 alkylthio or C.sub.2 to C.sub.4 acylthio; andX is oxo, hydroximino, C.sub.1 to C.sub.3 alkoxyimino, carboxy-alkoxyimino wherein the alkoxy has 2 to 4 carbon atoms or a salt-converted carboxy-alkoxy-imino wherein the alkoxy has 2 to 4 carbon atoms.Type: GrantFiled: December 24, 1980Date of Patent: May 4, 1982Assignee: Richter Gedeon Vegyeszeti Gyar Rt.Inventors: Katalin Szilagyi nee Farago, Sandor Solyom, Lajos Toldy, Inge Schafer, Eleonora Szondy, Janos Borvendeg, Ilona Hermann nee Szente
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Patent number: 4310549Abstract: 1-tert.-butylamino-3-(2,5-dichlorophenoxy)-2-propanol and its pharmaceutically acceptable acid addition salts possess hypotensive and bradycardizing effects. Thus they can be applied in human therapy for the treatment of hypertension and simultaneously also of tachycardia.Type: GrantFiled: September 4, 1979Date of Patent: January 12, 1982Inventors: Andor Hajos, Marton Fekete, Marianna Kurti, Tibor Lang, Lajos Toldy, Janos Borvendeg, Laszlo Nagy, Sandor Elek, Istvan Elekes, Istvan Polgari
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Patent number: 4287194Abstract: A pharmaceutical compositions with hypotensive effects which comprise a compound of formula (I) or a pharmaceutically acceptable acid addition salt thereof, ##STR1## wherein R.sup.1 is formula (II) ##STR2## wherein R.sup.4 and R.sup.5 each represent hydrogen, hydroxy, nitro at the same timeR.sup.2 and R.sup.3 are hydrogen, orR.sup.1 are 3-chloro-6-pyridazinylamino, 3-methyl-6-pyridazinylamino or 3-carbamoyl-6-pyridazinylamino, and at the same timeR.sup.2 and R.sup.3 form together formula (III), ##STR3## wherein R.sup.6 is C.sub.1-4 alkyl group,R.sup.7 is hydrogen or a C.sub.1-4 alkyl group, andn is an integer of 1 to 3, orR.sup.2 and R.sup.3 form together a group of the general formula (IV),=Q-R.sup.8 (IV)whereinQ is C.sub.5-7 cycloaliphatic, andR.sup.8 is hydrogen, a C.sub.1-4 alkoxycarbonyl or a C.sub.2-4 alkyl,and a compound of formula (V) or a pharmaceutically acceptable acid addition salt thereof, ##STR4## wherein R.sup.9 is naphthyl, 4-indolyl or 4-morpholino-1,2,5-thiadiazol-3-yl group or ##STR5## .Type: GrantFiled: July 6, 1979Date of Patent: September 1, 1981Assignee: Richter Gedeon Vegyeszeti Gyar Rt.Inventors: Edit Kosa, Janos Borvendeg, Zsuzsanna Huszti, Judit Kosary, Geza Szilagyi, Laszlo Tardos, Endre Kasztreiner, Laszlo Nagy, Erzsebet Szuucs, Gabriella Kiss
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Patent number: 4218446Abstract: Diuretic pharmaceutically active steroid-spiro-oxazolidinone compounds of the formula (I), ##STR1## wherein R.sup.1 is hydrogen or methyl,R.sup.2 is C.sub.1-4 alkyl,R.sup.3 is hydrogen, C.sub.1-4 alkyl or C.sub.2-4 alkenyl,Z.sup.1 and Z.sup.2 each are hydrogen or together form a second valence bond, or Z.sup.1 is hydrogen and Z.sup.2 is R.sup.4 --S--,Z.sup.3 and Z.sup.4 each are hydrogen or together form a second valence bond, or Z.sup.3 is hydrogen and Z.sup.4 is R.sup.4 --S--, with at least one of the pairs Z.sup.1 -Z.sup.2 and Z.sup.3 -Z.sup.4 representing hydrogen and an R.sup.4 --S-- group, andR.sup.4 is hydrogen or alkyl, alkenyl, aralkyl or acyl with up to 7 carbon atoms, provided that when Z.sup.1 and Z.sup.2 together form a valence bond, or Z.sup.1 represents a hydrogen atom and Z.sup.2 and R.sup.4 --S-- group then R.sup.1 is methyl.Type: GrantFiled: March 29, 1979Date of Patent: August 19, 1980Assignee: Richter Gedeon Vegyeszeti Gyar RtInventors: Sandor Solyom, Lajos Toldy, Katalin Szilagyi nee Farago, Inge Schafer, Eleonora Szondy, Janos Borvendeg, Ilona Hermann nee Szente
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Patent number: 4180505Abstract: The invention relates to novel spirooxazolidines represented by the formula I ##STR1## wherein R.sub.1 is alkyl having from 1 to 4 carbon atoms;R.sub.2 is hydrogen, alkyl having from 1 to 4 carbon atoms, alkenyl having from 1 to 4 carbon atoms, or dialkylphosphinoxymethyl having in the alkyl moiety from 1 to 3 carbon atoms each;Z is one of the groups represented by the formulae III to XIV as subsequently defined therein.Type: GrantFiled: March 14, 1978Date of Patent: December 25, 1979Assignee: Richter Gedeon Vegyeszet, Gyar RTInventors: Sandor S. L. Toldy, Katalin Szilagyi nee Farago, Inge Schafer, Eleonora Szondy, Janos Borvendeg, Ilona Hermann nee Szente
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Patent number: 4028348Abstract: Novel 6-amino-5.alpha.,19-cycloandrostane derivatives of formula I and their pharmaceutically acceptable addition salts ##STR1## wherein X denotes any of the groups of the formula =CH(OR), =CO or =C=N-OR.sub.1,Y denotes any of the groups of the formula =CO, =CH(OR.sub.1), =C=N-OR.sub.1, =C(OR.sub.1)-C.tbd.CH or ##STR2## wherein R denotes a hydrogen atom, a C.sub.1-4 alkyl group or a C.sub.2-5 acyl group, andR.sub.1 denotes a hydrogen atom, a straight-chained or branched C.sub.1-5 alkyl group, a straight-chained or branched C.sub.1-5 hydroxyalkyl group, a C.sub.3-8 cycloalkyl group, an allyl group, or a benzyl group, andR.sub.3 has the same meaning as R.sub.2 but if R.sub.2 is a sec. or tert. alkyl group or an alicyclic group, then R.sub.3 can only be a hydrogen atom; and if R.sub.2 is a benzyl group then R.sub.3 can only be a hydrogen atom or a primary alkyl group, furtherR.sub.2 and R.sub.3 may denote together with the adjcacent nitrogen atom a piperidine, a morpholine, or an N-methylpiperazine group.Type: GrantFiled: February 17, 1976Date of Patent: June 7, 1977Assignee: Richter Gedeon Vegyeszeti Gyar RTInventors: Pal Bite, Imre Moravcsik, Inge Schafer, Gyula Horvath, Zsuzsanna Mehesfalvi nee Vajna, Janos Borvendeg, Ilona Hermann nee Szente