Abstract: The present invention relates to processes for the preparation of tablets which dissolve rapidly in the mouth and provide an excellent mouthfeel. The tablets of the invention comprise a compound which melts at about 37° C. or lower, have a low hardness, high stability and generally comprise few insoluble disintegrants which may cause a gritty or chalky sensation in the mouth. Convenient and economically feasible processes by which the tablets of the invention may be produced are also provided.

Abstract: The present invention relates to processes for the preparation of tablets which dissolve rapidly in the mouth and provide an excellent mouthfeel. The tablets of the invention comprise a compound which melts at about 37° C. or lower, have a low hardness, high stability and generally comprise few insoluble disintegrants which may cause a gritty or chalky sensation in the mouth. Convenient and economically feasible processes by which the tablets of the invention may be produced are also provided.

Abstract: The present invention relates to processes for the preparation of tablets which dissolve rapidly in the mouth and provide an excellent mouthfeel. The tablets of the invention comprise a compound which melts at about 37° C. or lower, have a low hardness, high stability and generally comprise few insoluble disintegrants which may cause a gritty or chalky sensation in the mouth. Convenient and economically feasible processes by which the tablets of the invention may be produced are also provided.

Abstract: The present invention relates to processes for the preparation of tablets which dissolve rapidly in the mouth and provide an excellent mouthfeel. The tablets of the invention comprise a compound which melts at about 37° C. or lower, have a low hardness, high stability and generally comprise few insoluble disintegrants which may cause a gritty or chalky sensation in the mouth. Convenient and economically feasible processes by which the tablets of the invention may be produced are also provided.

Abstract: The present invention relates to a pharmacologic dosage unit which includes a multi-functional particulate system and a pharmacologically active agent. The multi-functional particulate system includes solid biologically-safe particles incorporated into a matrix and having a characteristic that each individual particle retains its original size. The invention also relates to methods of preparing, enhancing flow properties and compacting properties of a pharmacologic composition, increasing capacity for inclusion of ingredients, and increasing dispersion of actives. Finally, the invention includes a method for delivering an active agent to a patient.

Abstract: The present invention is directed to orally disintegrating dosage forms comprising lipid coated substrates and silicified excipients. The use of silicified excipients in the orally disintegrating dosage form along with lipid coating of active agents, allows for improvements in the ability to prepare these dosage forms. Further, the dosage form can prevent unpleasant taste or aftertaste and provide better chemical and mechanical stability of the coated active substrate. This present invention also provides the possibility of harder more durable tablets, along with targeted immediate or modified release profiles for the active agent.

Abstract: The present invention relates to processes for the preparation of tablets which dissolve rapidly in the mouth and provide an excellent mouthfeel. The tablets of the invention comprise a compound which melts at about 37° C. or lower, have a low hardness, high stability and generally comprise few insoluble disintegrants which may cause a gritty or chalky sensation in the mouth. Convenient and economically feasible processes by which the tablets of the invention may be produced are also provided.

Abstract: Pesticidal formulations of cadusafos are provided. An aqueous capsule suspension is provided, containing from about 150 to about 360 grams of cadusafos per liter of formulation and having lower mammalian toxicity than aqueous cadusafos microemulsion formulations is prepared by interfacial polymerization of a first polyfunctional compound, such as a polymethylene polyphenyl isocyanate, with a second polyfunctional compound, such as a polyfunctional amine or mixtures of polyfunctional amines, in an aqueous phase optionally containing from about 0.05 to about 0.50 xanthan gum viscosity modifier/stabilizer. A granular form of the microencapsulated cadusafos is also provided. Several such formulations and the method of their preparation are described.

Abstract: Provided is a method of encapsulating clomazone and a second biological agent comprising: (a) mixing (i) an aqueous phase, (ii) an emulsifier and (iii) a water-immiscible phase containing clomazone, the second biological agent, and at least one first polyfunctional compound; (b) forming a dispersion of water-immiscible droplets throughout the aqueous phase; and (c) adding at least one second polyfunctional compound into the dispersion and reacting the second polyfunctional compound(s) with the first polyfunctional compound(s) to form a polymer shell around the water-immiscible droplets.

Abstract: The present invention provides herbicidal formulation that is composed of an aqueous liquid having suspended therein a multitude of microcapsules having a capsule wall of a porous polymer encapsulating a solution of clomazone, and suitable concentrations of fat in the absence of a resin, or a resin in the absence of a fat, or both fat and resin. Preferably, if included, the fat is at least 95% saturated.

Abstract: The present invention provides an herbicidal formulation that is composed of an aqueous liquid having suspended therein a multitude of microcapsules having a capsule wall of a porous polymer encapsulating a solution of clomazone, and suitable concentrations of fat in the absence of a resin, or a resin in the absence of a fat, or both fat and resin. Preferably, if included, the fat is at least 95% saturated.

Abstract: The present invention provides an herbicidal formulation that is composed of an aqueous liquid having suspended therein a multitude of microcapsules having a capsule wall of a porous polymer encapsulating a solution of clomazone, and suitable concentrations of fat in the absence of a resin, or a resin in the absence of a fat, or both fat and resin. Preferably, if included, the fat is at least 95% saturated.

Abstract: The present invention provides a solid water soluble granular composition which comprises an imidazolinone herbicide alone or in combination with a second herbicide and a base, preferably wherein the base is present at a ratio of about 0.9 to 2.0 molar equivalents of base to molar equivalents of imidazolinone herbicide. Said composition is storage stable and dissolves rapidly and essentially completely in water for even application to target surfaces.