Patents by Inventor Janus Krarup

Janus Krarup has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of controlling a polypeptide modification reaction
    Patent number: 10851364
    Abstract: The invention relates to a method of controlling a polypeptide modification reaction, in particular but not exclusively, a method of controlling the activation of human factor VII (FVII) to produce human factor VII(a) (FVII(a)). The invention also relates to polypeptides obtainable by the polypeptide modification reaction and to pharmaceutical compositions comprising said polypeptides.
    Type: Grant
    Filed: March 13, 2018
    Date of Patent: December 1, 2020
    Assignee: NOVO NORDISK HEALTHCARE AG
    Inventors: Lars Sejergaard, Janus Krarup
  • Method of Controlling a Polypeptide Modification Reaction
    Publication number: 20180362953
    Abstract: The invention relates to a method of controlling a polypeptide modification reaction, in particular but not exclusively, a method of controlling the activation of human factor VII (FVII) to produce human factor VII(a) (FVII(a)). The invention also relates to polypeptides obtainable by the polypeptide modification reaction and to pharmaceutical compositions comprising said polypeptides.
    Type: Application
    Filed: March 13, 2018
    Publication date: December 20, 2018
    Inventors: Lars Sejergaard, Janus Krarup
  • Reduction of dimer content in factor VII polypeptide compositions by heat treatment
    Patent number: 10047354
    Abstract: The present application relates to a method of reducing the content of dimers in Factor VII polypeptide composition by heat treatment.
    Type: Grant
    Filed: August 22, 2008
    Date of Patent: August 14, 2018
    Assignee: Novo Nordisk Health Care AG
    Inventor: Janus Krarup
  • Method of Controlling a Polypeptide Modification Reaction
    Publication number: 20160130573
    Abstract: The invention relates to a method of controlling a polypeptide modification reaction, in particular but not exclusively, a method of controlling the activation of human factor VII (FVII) to produce human factor VII(a) (FVII(a)). The invention also relates to polypeptides obtainable by the polypeptide modification reaction and to pharmaceutical compositions comprising said polypeptides.
    Type: Application
    Filed: November 6, 2015
    Publication date: May 12, 2016
    Inventors: Lars Sejergaard, Janus Krarup
  • Reduction of the content of protein contaminants in compositions comprising a vitamin K-dependent protein of interest
    Patent number: 9187549
    Abstract: The present invention relates to Vitamin K-dependent protein compositions having a very low, or negligible, content of protein contaminants. The present invention also relates to method applicable in the preparation of such Vitamin K-dependent protein compositions. Such methods may either be used alone or in sequential combination with the purpose of reducing the relative content of protein contaminants. The present invention is particularly relevant in the preparation of compositions of coagulation factors selected from Factor X polypeptides (FX/FXa), Factor IX polypeptides (FIX/FIXa), Factor VII polypeptides (FVII/FVIIa), and the anticoagulant Protein C, in particular Factor VII polypeptides.
    Type: Grant
    Filed: December 23, 2005
    Date of Patent: November 17, 2015
    Assignee: Novo Nordisk Healthcare A/G
    Inventors: Janus Krarup, Thomas Budde Hansen, Anne Charlotte Arentsen, Daniel E. Rasmussen, Are Bogsnes, Arne Staby, Haleh Ahmadian, Susanne Bang
  • Hydrophobic interaction chromatography purification of factor VII polypeptides
    Patent number: 9023992
    Abstract: The invention described herein provides new methods of preparing purified Factor VII polypeptide drug substances in large quantities (industrial scale levels) that are associated with reduced content of product-related impurities (e.g., late eluting peaks) and/or that exhibit a relatively uniform glycosylation pattern.
    Type: Grant
    Filed: September 17, 2010
    Date of Patent: May 5, 2015
    Assignee: Novo Nordisk Healthcare AG
    Inventors: Daniel E. Rasmussen, Janus Krarup
  • Method for the production of proteins
    Patent number: 8921530
    Abstract: The present invention relates to a process for the purification of a protease.
    Type: Grant
    Filed: June 10, 2013
    Date of Patent: December 30, 2014
    Assignee: Novo Nordisk Healthcare AG
    Inventor: Janus Krarup
  • AQUEOUS FACTOR VIII SOLUTION
    Publication number: 20130345403
    Abstract: The present invention relates to methods for stabilizing FVIII in aqueous solutions comprising a relatively high concentration of FVIII. The invention furthermore relates to such aqueous solutions as well as use thereof.
    Type: Application
    Filed: November 30, 2011
    Publication date: December 26, 2013
    Applicant: NOVO NORDISK A/S
    Inventors: Christian Rischel, Christina Jespersgaard, Are Bogsnes, Janus Krarup
  • Method for the Production of Proteins
    Publication number: 20130260439
    Abstract: The present invention relates to a process for the purification of a protease.
    Type: Application
    Filed: June 10, 2013
    Publication date: October 3, 2013
    Applicant: Novo Nordisk Health Care AG
    Inventor: Janus Krarup
  • Method for the production of proteins
    Patent number: 8530630
    Abstract: The present invention relates to a process for the purification of a protease.
    Type: Grant
    Filed: December 20, 2010
    Date of Patent: September 10, 2013
    Assignee: Novo Nordisk Healthcare A/G
    Inventor: Janus Krarup
  • Method for the production of proteins
    Patent number: 8084587
    Abstract: The present invention relates to a process for the purification of a protease.
    Type: Grant
    Filed: January 26, 2010
    Date of Patent: December 27, 2011
    Assignee: Novo Nordisk Health Care AG
    Inventors: Janus Krarup, Egon Persson
  • Method of Controlling a Polypeptide Modification Reaction
    Publication number: 20110177580
    Abstract: The invention relates to a method of controlling a polypeptide modification reaction, in particular but not exclusively, a method of controlling the activation of human factor VII (FVII) to produce human factor VII(a) (FVII(a)). The invention also relates to polypeptides obtainable by the polypeptide modification reaction and to pharmaceutical compositions comprising said polypeptides.
    Type: Application
    Filed: May 29, 2009
    Publication date: July 21, 2011
    Applicant: Novo Nordisk HEalthcare AG
    Inventors: Lars Sejergaard, Janus Krarup
  • Method for the Production of Proteins
    Publication number: 20110081702
    Abstract: The present invention relates to a process for the purification of a protease.
    Type: Application
    Filed: December 20, 2010
    Publication date: April 7, 2011
    Applicant: Novo Nordisk HealthCare A/G
    Inventors: Janus Krarup, Egon Persson
  • HYDROPHOBIC INTERACTION CHROMATOGRAPHY PURIFICATION OF FACTOR VII POLYPEPTIDES
    Publication number: 20110064719
    Abstract: The invention described herein provides new methods of preparing purified Factor VII polypeptide drug substances in large quantities (industrial scale levels) that are associated with reduced content of product-related impurities (e.g., late eluting peaks) and/or that exhibit a relatively uniform glycosylation pattern.
    Type: Application
    Filed: September 17, 2010
    Publication date: March 17, 2011
    Applicant: Novo Nordisk A/S
    Inventors: DANIEL E. RASMUSSEN, JANUS KRARUP
  • Method for the production of proteins
    Patent number: 7897734
    Abstract: The present invention relates to a process for the purification of a protease.
    Type: Grant
    Filed: September 15, 2005
    Date of Patent: March 1, 2011
    Assignee: Novo Nordisk Healthcare AG
    Inventor: Janus Krarup
  • Reduction of Dimer Content in Factor VII Polypeptide Compositions by Heat Treatment
    Publication number: 20110003363
    Abstract: The present application relates to a method of reducing the content of dimers in Factor VII polypeptide composition by heat treatment.
    Type: Application
    Filed: August 22, 2008
    Publication date: January 6, 2011
    Applicant: Novo Nordisk Health Care AG
    Inventor: Janus Krarup
  • Method for the Production of Proteins
    Publication number: 20100136622
    Abstract: The present invention relates to a process for the purification of a protease.
    Type: Application
    Filed: January 26, 2010
    Publication date: June 3, 2010
    Applicant: Novo Nordisk HealthCare A/G
    Inventors: Janus Krarup, Egon Persson
  • Purification of a Drug Substance of a Factor VII Polypeptide by Removal of DesGla-Factor VII Polypeptide Structures
    Publication number: 20090042784
    Abstract: The present invention relates to a purification process for drug substances of a Factor VII polypeptide having an impurity in the form of desGla-Factor VII polypeptide structures. The process utilizes an anion-exchange material and includes washing and/or elution with a buffer of a predetermined pH.
    Type: Application
    Filed: September 29, 2005
    Publication date: February 12, 2009
    Inventor: Janus Krarup
  • FVII Specific Antibodies and Use Thereof
    Publication number: 20090017557
    Abstract: The present invention relates to novel antibodies against FVII, use for determining amount of correctly folded and intact FVII in a sample, as well as for purification and process optimization.
    Type: Application
    Filed: August 31, 2006
    Publication date: January 15, 2009
    Applicant: Novo Nordisk HealthCare A/G
    Inventors: Hans Kurt Pingel, Else Marie Nicolaisen, Janus Krarup
  • Reduction of the Content of Protein Contaminents in Compositions Comprising a Vitamin K-Dependent Protein of Interest
    Publication number: 20080207880
    Abstract: The present invention relates to Vitamin K-dependent protein compositions having a very low, or negligible, content of protein contaminants. The present invention also relates to method applicable in the preparation of such Vitamin K-dependent protein compositions. Such methods may either be used alone or in sequential combination with the purpose of reducing the relative content of protein contaminants. The present invention is particularly relevant in the preparation of compositions of coagulation factors selected from Factor X polypeptides (FX/FXa), Factor IX polypeptides (FIX/FIXa), Factor VII polypeptides (FVII/FVIIa), and the anticoagulant Protein C, in particular Factor VII polypeptides.
    Type: Application
    Filed: December 23, 2005
    Publication date: August 28, 2008
    Applicant: Novo Nordisk HealthCare A/G
    Inventors: Janus Krarup, Thomas Budde Hansen, Anne Charlotte Arentsen, Daniel E. Rasmussen, Are Bognes, Arne Staby, Haleh Ahmadian, Susanne Bang