Abstract: An improved method and an improved instrument for analyte determination that uses infrared radiation naturally emitted by subject are disclosed. The method is based on Thermal Emission Spectroscopy (TES) whereby the spectral signal is measured in reference to a body's physiological and ambient parameters. The instrument that realizes the method incorporates temperature and humidity sensors. Ambient environmental parameters and subject parameters as disclosed allow normalization of spectrally specific analyte signal for grater precision and accuracy of analytes concentration determination. Such improvement leads to a universal calibration in, for example, non-invasive blood glucose measurements in human subjects.

Abstract: A method, apparatus and procedure for the non-invasive detection of the sugar concentration changes in body liquids such as blood is disclosed. The instrument measures sugar concentration changes using the natural fingerprint of sugar which is rotations of polarization of light emitted from the biological particle chromophores dissolved together with sugar in human liquids. The degree of polarization of light emitted from luminescence centers undergoing interaction with an optically active medium such as sugar is proportional to the concentration of sugar in, for example, blood. The reference level is determined by conventional blood analysis using standard monitoring equipment during the special procedure of the Glucose Tolerance Test.