Abstract: A method of identifying and quantifying copy number variations in a gene of interest for a genomic DNA sample includes (i) fragmenting a genomic DNA sample to produce a plurality of polynucleotide fragments, (ii) isolating a plurality of target polynucleotide fragments, (iii) sequencing the plurality of target polynucleotide fragments, (iv) aligning fragment sequences to a reference sequence, (v) calculating read depths for base positions of the plurality of target polynucleotide fragments, (vi) calculating copy number likelihoods for each base position of the reference sequence, (vii) performing a breakpoint analysis on a set of fragment sequences to identify at least one sequence variation located between selected breakpoint regions of the target gene and calculate modified copy number likelihoods for base positions of the reference sequence based on the at least one sequence variation, and (viii) determining whether the target gene includes at least one copy number variation.

Abstract: In some embodiments, an electronic device presents representations of messaging conversations. In some embodiments, an electronic device indicates which messages are replies to other messages in a messaging conversation. In some embodiments, an electronic device creates and presents links (e.g., rich links) to contacts in a messaging conversation (e.g., “mentions”). In some embodiments, an electronic device presents indications of messages that are replies to other messages. In some embodiments, an electronic device presents options to create a link (e.g., a rich link) to contacts in a messaging conversation (e.g., “mentions”) using a suggested entry user interface element.

Abstract: The present disclosure relates to a laboratory execution system that provides for automation of laboratory processes. A centralized data management system may be dynamically updated and used to facilitate management of components of the laboratory execution system, such as an automation system and an analytics results management system that may facilitate complex analytical functions, such as synthesizing raw test data. Potential workflows include the detection of specific molecules of interest.

Abstract: This disclosure describes techniques for providing instructions when receiving biometric data associated with a user. For instance, a device may detect a portion of a user, such as a hand. The device may then display a first graphical element indicating a target location for placing the portion of the user above the user-recognition device. Additionally, the device may determine locations of the portion of the user above the device. The device may then display a second graphical element indicating the locations, such as when the locations are not proximate to the target location. Additionally, the device may display instructions for moving the portion of the user to the target location. Based on detecting that the location of the portion of the user is proximate to the target location, the device may send data representing the portion of the user to a remote system.

Abstract: The present disclosure relates to methods for detecting unique genetic signatures derived from markers such as, for example, mutations, somatic or germ-line, in nucleic acids obtained from biological samples. The sensitivity of the methods provides for detection of mutations associated with a disease, e.g., cancer mutations, or with inherited disease, e.g., an autosomal recessive disease, in a noninvasive manner at ultra-low proportions of sequences carrying mutations to sequences carrying normal, e.g., non-cancer sequences, or a reference sequence, e.g., a human reference genome.

Abstract: The present disclosure relates to a laboratory execution system that provides for automation of laboratory processes. A centralized data management system may be dynamically updated and used to facilitate management of components of the laboratory execution system, such as an automation system and an analytics results management system that may facilitate complex analytical functions, such as synthesizing raw test data. Potential workflows include the detection of specific molecules of interest.

Abstract: A turbine engine having a compressor section, a combustor section, a turbine section, and a rotatable drive shaft that couples a portion of the turbine section and a portion of the compressor section. A bypass conduit couples the compressor section to the turbine section while bypassing at least the combustion section. At least one particle separator is located in the turbine engine having a separator inlet that receives a bypass stream, a separator outlet that receives a reduced-particle stream flows, and a particle outlet that receives a concentrated-particle stream comprising separated particles. A conduit, fluidly coupled to the particle outlet, extends through an interior of at least one stationary vane.

Abstract: Devices and methods for withdrawing bodily fluid from a subject are disclosed herein. In some embodiments, a handheld device can include a housing having an opening, a skin-piercing assembly, and an actuator coupled to the skin-piercing assembly. The skin-piercing assembly can include a casing, a drive member pivotably mounted within the casing and carrying a blade, and a biasing member coupling the drive member to the casing. The actuator can be movable relative to the housing from a first position to a second position. In the first position, the drive member can engage the casing to maintain the biasing member in a biased configuration. Movement of the actuator from the first position to the second position can disengage the drive member from the casing to permit the biasing member to drive the blade at least partially through and/or across the opening in the base.

Abstract: In some embodiments, an oral device can include a curved frame, a first bite block, and a second bite block. The first bite block can be coupled to a first end of the curved frame and the second bite block can be coupled to a second end of the curved frame. A first wing coupled to the first bite block and a second wing coupled to the second bite block can be configured to corral a tongue of a user such that the tongue of the user is restrained from contacting a tooth engaging surface of the left bite block or the right bite block when the oral device is disposed in a mouth of the user. The oral device can be symmetrical about a plane including a portion of the frame, a portion of the first bite block, and a portion of the second bite block.

Abstract: Methods and compositions for inhibiting corrosion of a corrodible metal surface that contact a nitrogen-containing solution. The method comprises adding a chemical treatment composition to the nitrogen-containing solution that includes an organic filmer and a passivator. The organic filmer may be a hydroxycarboxylic acid. The chemical treatment composition may further include a surface-active compound.

Abstract: Apparatuses, system, and computer-implemented methods to facilitate physical representation of quantum entanglement are provided. According to an embodiment, an apparatus can comprise two or more qubit representation devices that interact with one another in a defined manner, and a display component operatively coupled to at least one of the two or more qubit representation devices, wherein the display component outputs a visual indicator of quantum entanglement between the two or more qubit representation devices.

Abstract: Embodiments herein provide methods, systems, suitable for the analysis of both complex and conventional data pertaining to an individual user or human activity that is received in real-time and/or in batches from a variety of data source types, to identify and produce results that benefit the individual user. One general aspect includes a method comprising: receiving input data from a plurality of peripheral devices, e.g., one or more interface devices for a user device; analyzing the input data to generate a plurality of data analysis streams of time-series data relating to a user of for a first period of time; generating a plurality of user or system generated insight based time tags for second periods of time within the first period of time; and generating a dashboard for display to the user.

Abstract: A door includes a first skin, a second skin, two stiles, a core, and a gas permeable membrane. The first skin provides a first outer door surface. The second skin provides a second outer door surface. The two stiles are disposed at least partially between the first skin and the second skin. At least one stile defines a vent therein. The core comprises a foam material and is disposed between the first skin and the second skin. The gas permeable membrane, which is permeable to gas but not to the precursors of a foam material, is disposed on the at least one stile covering the vent. The gas permeable membrane contacts the foam material in the core, and separate the foam material in the core from the vent.

Abstract: Devices and methods for withdrawing bodily fluid from a subject are disclosed herein. In some embodiments, a handheld device can include a housing having an opening, a skin-piercing assembly, and an actuator coupled to the skin-piercing assembly. The skin-piercing assembly can include a casing, a drive member pivotably mounted within the casing and carrying a blade, and a biasing member coupling the drive member to the casing. The actuator can be movable relative to the housing from a first position to a second position. In the first position, the drive member can engage the casing to maintain the biasing member in a biased configuration. Movement of the actuator from the first position to the second position can disengage the drive member from the casing to permit the biasing member to drive the blade at least partially through and/or across the opening in the base.

Abstract: A quantum state visualization device comprising at least a portion of a spherical shell and a support structure affixed to the spherical shell. A portion of the support structure can intersect a center of the spherical shell. The quantum state visualization device further comprising a indicator pivotally attached to the support structure at the portion of the support structure intersecting the center of the spherical shell. The indicator is representative of a quantum state based on its position relative to the spherical shell.

Abstract: Systems, computer-implemented methods, and computer program products to facilitate quantum platform routing of a quantum application component are provided. According to an embodiment, a system can comprise a memory that stores computer executable components and a processor that executes the computer executable components stored in the memory. The computer executable components can comprise a dissection component that identifies one or more components of a quantum application. The computer executable components can further comprise a determination component that selects at least one quantum platform to execute the one or more components of the quantum application based on a defined run criterion.

Abstract: Methods and compositions for inhibiting corrosion of a corrodible metal surface that contact a nitrogen-containing solution. The method comprises adding a chemical treatment composition to the nitrogen-containing solution that includes an organic filmer and a passivator. The organic filmer may be a hydroxycarboxylic acid. The chemical treatment composition may further include a surface-active compound.

Abstract: A door include a first skin, a second skin, and a glazing unit. The first skin includes a first skin body portion, and a first flange portion extending inward from the first skin body portion. The first skin body portion has a first tip. A second skin includes a second skin body portion, and a second flange portion extending inward from the second skin body portion. The second skin body portion has a second tip. A glazing unit has an edge disposed adjacent to and between the first tip and the second tip. The first flange portion and the second flange portion provide an interlocking structure.

Abstract: A door includes a first skin, a second skin, two stiles, a core, and a gas permeable membrane. The first skin provides a first outer door surface. The second skin provides a second outer door surface. The two stiles are disposed at least partially between the first skin and the second skin. At least one stile defines a vent therein. The core comprises a foam material and is disposed between the first skin and the second skin. The gas permeable membrane, which is permeable to gas but not to the precursors of a foam material, is disposed on the at least one stile covering the vent. The gas permeable membrane contacts the foam material in the core, and separate the foam material in the core from the vent.