Abstract: Devices, systems, and methods manipulate target materials within fluids, and may be useful for removing microbubbles and other materials from blood. Ultrasound or acoustic filtering waves may be directed across a flow of blood, and differences in density between the target microbubbles and the blood may enhance separation by driving the lighter matter upward for removal from the blood stream. A disposable acoustically transmissive conduit can replaceably engage an ultrasound transmitter to facilitate sterilization. Exemplary conduits have elongate lumen cross-sections and an axial path resembling a portion of a Mobius strip.

Abstract: Devices, systems, and methods manipulate target materials within fluids, and may be useful for removing microbubbles and other materials from blood. Ultrasound or acoustic filtering waves may be directed across a flow of blood, and differences in density between the target microbubbles and the blood may enhance separation by driving the lighter matter upward for removal from the blood stream. A disposable acoustically transmissive conduit can replaceably engage an ultrasound transmitter to facilitate sterilization. Exemplary conduits have elongate lumen cross-sections and an axial path resembling a portion of a Mobius strip.