Patents by Inventor Jared J. Drader
Jared J. Drader has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20150014548Abstract: The invention relates generally to sample ionization, and provides ionization probe assemblies, systems, computer program products, and methods useful for this purpose.Type: ApplicationFiled: August 4, 2014Publication date: January 15, 2015Inventors: Steven A. Hofstadler, Jose R. Gutierrez, James C. Hannis, Jared J. Drader, Rex O. Bare, Jeffrey C. Smith, Paul J. Gleason, Jared Nathanson
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Publication number: 20140307520Abstract: Cartridges useful for mixing materials, such as fluidic materials are provided. A cartridge typically includes a body structure having surfaces that define a cavity with upper and lower portions. A rotatable member generally extends along a horizontal axis in the upper portion of the cavity. One or more protrusions typically extend outward from the rotatable member and into the lower portion of the cavity, and are configured to mix the material when the material is disposed in the cavity. Related mixing stations, systems, kits, and methods are also provided.Type: ApplicationFiled: October 7, 2013Publication date: October 16, 2014Applicant: IBIS BIOSCIENCES, INC.Inventors: Steven A. Hofstadler, Jared J. Drader, Jose R. Gutierrez, Rex O. Bare, Robert D. Miller, Jeffrey C. Smith
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Publication number: 20140224042Abstract: Sample processing units useful for mixing and purifying materials, such as fluidic materials are provided. A sample processing unit typically includes a container configured to contain a sample comprising magnetically responsive particles, and one or more magnets that are in substantially fixed positions relative to the container. A sample processing unit also generally includes a conveyance mechanism configured to convey the container to and from a position that is within magnetic communication with the magnet, e.g., such that magnetically responsive particles with captured analytes can be retained within the container when other materials are added to and/or removed from the container. Further, a sample processing unit also typically includes a rotational mechanism that is configured to rotate the container, e.g., to effect mixing of sample materials disposed within the container. Related carrier mechanisms, sample processing stations, systems, and methods are also provided.Type: ApplicationFiled: December 10, 2013Publication date: August 14, 2014Applicant: IBIS BIOSCIENCES, INC.Inventors: Steven A. Hofstadler, Jared J. Drader, Jose R. Gutierrez, Paul J. Gleason, Rex O. Bare, Robert D. Miller, Jeffrey C. Smith
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Patent number: 8796617Abstract: The invention relates generally to sample ionization, and provides ionization probe assemblies, systems, computer program products, and methods useful for this purpose.Type: GrantFiled: January 3, 2012Date of Patent: August 5, 2014Assignee: Ibis BioSciences, Inc.Inventors: Steven A. Hofstadler, Jose R. Gutierrez, James C. Hannis, Jared J. Drader, Rex O. Bare, Jeffrey C. Smith, Paul J. Gleason, Jared Nathanson
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Publication number: 20140154043Abstract: Systems, computer program products, and methods useful for handling or managing microplates are provided.Type: ApplicationFiled: September 16, 2013Publication date: June 5, 2014Applicant: IBIS BIOSCIENCES, INC.Inventors: Steven A. Hofstadler, Jared J. Drader, Jose R. Gutierrez, Paul J. Gleason, Rex O. Bare, Robert D. Miller, Jeffrey C. Smith, Kevin S. Oberkramer, Ronald K. Bergold
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Patent number: 8614087Abstract: Provided herein is technology relating to testing biological samples and particularly, but not exclusively, to devices, systems, and kits for performing multiple, simultaneous real-time assays on a sample in a single-use disposable format. For example, the technology relates to an apparatus that finds use, for example, for point-of-care diagnostics, including use at accident sites, emergency rooms, in surgery, in intensive care units, as well as for non-medical applications.Type: GrantFiled: May 2, 2012Date of Patent: December 24, 2013Assignee: Ibis Biosciences, Inc.Inventors: Jared J. Drader, Gordon Bruce Collier, Steven A. Hofstadler
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Patent number: 8609430Abstract: Sample processing units useful for mixing and purifying materials, such as fluidic materials are provided. A sample processing unit typically includes a container configured to contain a sample comprising magnetically responsive particles, and one or more magnets that are in substantially fixed positions relative to the container. A sample processing unit also generally includes a conveyance mechanism configured to convey the container to and from a position that is within magnetic communication with the magnet, e.g., such that magnetically responsive particles with captured analytes can be retained within the container when other materials are added to and/or removed from the container. Further, a sample processing unit also typically includes a rotational mechanism that is configured to rotate the container, e.g., to effect mixing of sample materials disposed within the container. Related carrier mechanisms, sample processing stations, systems, and methods are also provided.Type: GrantFiled: August 27, 2012Date of Patent: December 17, 2013Assignee: Ibis Biosciences, Inc.Inventors: Steven A. Hofstadler, Jared J. Drader, Jose R. Gutierrez, Paul J. Gleason, Rex O. Bare, Robert D. Miller, Jeffrey C. Smith
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Patent number: 8550694Abstract: Cartridges useful for mixing materials, such as fluidic materials are provided. A cartridge typically includes a body structure having surfaces that define a cavity with upper and lower portions. A rotatable member generally extends along a horizontal axis in the upper portion of the cavity. One or more protrusions typically extend outward from the rotatable member and into the lower portion of the cavity, and are configured to mix the material when the material is disposed in the cavity. Related mixing stations, systems, kits, and methods are also provided.Type: GrantFiled: September 16, 2009Date of Patent: October 8, 2013Assignee: Ibis Biosciences, Inc.Inventors: Steven A. Hofstadler, Jared J. Drader, Jose R. Gutierrez, Rex O. Bare, Robert D. Miller, Jeffrey C. Smith
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Patent number: 8534447Abstract: Systems, computer program products, and methods useful for handling or managing microplates are provided.Type: GrantFiled: September 16, 2009Date of Patent: September 17, 2013Assignee: Ibis Biosciences, Inc.Inventors: Steven A. Hofstadler, Jared J. Drader, Jose R. Gutierrez, Paul J. Gleason, Rex O. Bare, Robert D. Miller, Jeffrey C. Smith, Kevin S. Oberkramer, Ronald K. Bergold
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Publication number: 20130092830Abstract: The methods described herein generally relate to characterization of large analytes, such as biomolecules, by molecular mass analysis. Specifically, the methods are directed to molecular mass analysis of singly- or multiply-charged ions by selective ion filtering carried out by a digital thresholding process.Type: ApplicationFiled: May 7, 2012Publication date: April 18, 2013Applicant: IBIS BIOSCIENCES, INC.Inventors: Steven A. Hofstadler, Jared J. Drader, Amy L. Schink
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Publication number: 20130059372Abstract: Sample processing units useful for mixing and purifying materials, such as fluidic materials are provided. A sample processing unit typically includes a container configured to contain a sample comprising magnetically responsive particles, and one or more magnets that are in substantially fixed positions relative to the container. A sample processing unit also generally includes a conveyance mechanism configured to convey the container to and from a position that is within magnetic communication with the magnet, e.g., such that magnetically responsive particles with captured analytes can be retained within the container when other materials are added to and/or removed from the container. Further, a sample processing unit also typically includes a rotational mechanism that is configured to rotate the container, e.g., to effect mixing of sample materials disposed within the container. Related carrier mechanisms, sample processing stations, systems, and methods are also provided.Type: ApplicationFiled: August 27, 2012Publication date: March 7, 2013Applicant: IBIS BIOSCIENCES, INC.Inventors: Steven A. Hofstadler, Jared J. Drader, Jose R. Gutierrez, Paul J. Gleason, Rex O. Bare, Robert D. Miller, Jeffrey C. Smith
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Publication number: 20120282602Abstract: Provided herein is technology relating to testing biological samples and particularly, but not exclusively, to devices, systems, and kits for performing multiple, simultaneous real-time assays on a sample in a single-use disposable format. For example, the technology relates to an apparatus that finds use, for example, for point-of-care diagnostics, including use at accident sites, emergency rooms, in surgery, in intensive care units, as well as for non-medical applications.Type: ApplicationFiled: May 2, 2012Publication date: November 8, 2012Applicant: IBIS BIOSCIENCES, INC.Inventors: Jared J. Drader, Gordon Bruce Collier, Steven A. Hofstadler
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Patent number: 8268565Abstract: The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.Type: GrantFiled: December 2, 2008Date of Patent: September 18, 2012Assignee: Ibis Biosciences, Inc.Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Stephen A. Hofstadler, John McNeil, Stanley T. Crooke, Lawrence B. Blyn, Thomas A. Hall, Yun Jiang, James C. Hannis, Neill White, Vivek Samant, Mark W. Eshoo, Jared J. Drader
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Patent number: 8252599Abstract: Sample processing units useful for mixing and purifying materials, such as fluidic materials are provided. A sample processing unit typically includes a container configured to contain a sample comprising magnetically responsive particles, and one or more magnets that are in substantially fixed positions relative to the container. A sample processing unit also generally includes a conveyance mechanism configured to convey the container to and from a position that is within magnetic communication with the magnet, e.g., such that magnetically responsive particles with captured analytes can be retained within the container when other materials are added to and/or removed from the container. Further, a sample processing unit also typically includes a rotational mechanism that is configured to rotate the container, e.g., to effect mixing of sample materials disposed within the container. Related carrier mechanisms, sample processing stations, systems, and methods are also provided.Type: GrantFiled: August 30, 2011Date of Patent: August 28, 2012Assignee: Ibis Biosciences, Inc.Inventors: Steven A. Hofstadler, Jared J. Drader, Jose R. Gutierrez, Paul J. Gleason, Rex O. Bare, Robert D. Miller, Jeffrey C. Smith
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Publication number: 20120190126Abstract: Provided herein are apparatuses and methods for fragmenting nucleic acids or disrupting cells. For example, some embodiments provide a disposable microfluidic device designed to position a sample to be in direct contact with a high frequency vibrating element that emits an ultrasonic frequency into the sample such that the vibrational energy transduced into the sample results in fragmenting nucleic acids or disrupting cells.Type: ApplicationFiled: January 20, 2012Publication date: July 26, 2012Applicant: IBIS BIOSCIENCES, INC.Inventors: Mark W. Eshoo, Jose R. Gutierrez, Jared J. Drader, John Picuri, Karl M. Cabrera, Stanley Motley
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Patent number: 8188011Abstract: The present invention provides methods for the identification ligand compounds that bind to target molecules such as proteins or structured RNA with as little as millimolar (mM) affinity using mass spectrometry. The methods may be used to determine the mode of binding interaction between two or more of these ligand compounds to the target as well as their relative affinities. Also provided are methods for designing compounds having greater affinity to a target molecule by identifying two or more ligands using mass spectrometry methods of the invention and linking the ligands together to form a novel compound.Type: GrantFiled: May 16, 2000Date of Patent: May 29, 2012Assignee: Isis Pharmaceuticals, Inc.Inventors: Richard Griffey, Steven Hofstadler, Jared J. Drader, Kristin S. Lowery
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Publication number: 20120115213Abstract: The present invention provides systems and methods for analysis of samples, particularly biological and environmental sample to detect biomolecules of interest contained therein. A variety of system components are described herein, including, but not limited to, components for sample handling, mixing of materials, sample processing, transfer of materials, and analysis of materials. The invention further provides mechanisms for combining and integrating the different components and for housing, moving, and storing system components or the system as a whole. The systems may include any one or more or all of these components. The system finds particular use when employed for analysis of nucleic acid molecule using mass spectrometry, however, the invention is not limited such specific uses.Type: ApplicationFiled: July 15, 2010Publication date: May 10, 2012Applicant: IBIS BIOSCIENCES, INC.Inventors: Steven A. Hofstadler, Jose R. Gutierrez, James C. Hannis, Jared J. Drader, Rex O. Bare, Jeffrey C. Smith, Paul J. Gleason, Jared H. Nathanson, Ronald K. Bergold, Robert D. Miller, Kevin S. Oberkramer
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Patent number: 8173957Abstract: The methods described herein generally relate to characterization of large analytes, such as biomolecules, by molecular mass analysis. Specifically, the methods are directed to molecular mass analysis of singly- or multiply-charged ions by selective ion filtering carried out by a digital thresholding process.Type: GrantFiled: January 26, 2010Date of Patent: May 8, 2012Assignee: Ibis Biosciences, Inc.Inventors: Steven A. Hofstadler, Jared J. Drader, Amy L. Schink
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Publication number: 20120097846Abstract: The invention relates generally to sample ionization, and provides ionization probe assemblies, systems, computer program products, and methods useful for this purpose.Type: ApplicationFiled: January 3, 2012Publication date: April 26, 2012Applicant: IBIS BIOSCIENCES, INC.Inventors: Steven A. Hofstadler, Jose R. Gutierrez, James C. Hannis, Jared J. Drader, Rex O. Bare, Jeffrey C. Smith, Paul J. Gleason, Jared Nathanson
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Patent number: 8158936Abstract: The invention relates generally to sample ionization, and provides ionization probe assemblies, systems, computer program products, and methods useful for this purpose.Type: GrantFiled: February 12, 2010Date of Patent: April 17, 2012Assignee: Ibis Biosciences, Inc.Inventors: Steven A. Hofstadler, Jose R. Gutierrez, James C. Hannis, Jared J. Drader, Rex O. Bare, Jeffrey C. Smith, Paul J. Gleason, Jared Nathanson