Patents by Inventor Jared Lynn Randall
Jared Lynn Randall has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10370403Abstract: Disclosed herein are methods of making ceragnenin compounds for treating, preventing, or diagnosing diseases, disorders, or conditions associated with bacterial or viral infections, cancer, inflammation, and osteogenesis. Ceragenin compounds display broad-spectrum antibacterial activity utilizing a mode of action similar to antimicrobial peptides, but without the high synthesis costs and susceptibility to proteolytic degradation. Ceragenin compounds reproduce the amphiphilic morphology found in many antimicrobial peptides and display potent and diverse biological activities, including anti-bacterial, anti-cancer, anti-inflammatory, bone growth promotion, and wound healing promotion.Type: GrantFiled: April 22, 2016Date of Patent: August 6, 2019Assignee: Brigham Young UniversityInventors: Paul B. Savage, Thomas E. Jacks, Ross A. Miller, Andrew S. Thompson, Jared Lynn Randall
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Publication number: 20170174720Abstract: Disclosed herein are acid addition salts of cationic steroidal antimicrobials (“CSAs” or “ceragenins”) and methods of making the same. Particularly advantageous salt forms are identified, such as 1,5-naphthalenedisulfonic acid addition salts and sulfate addition salts. The acid addition salts may be formulated for treating subjects with ailments responsive to CSAs, including but not limited to treating bacterial infections. Accordingly, some embodiments include formulations and methods of administering acid addition salts of CSAs.Type: ApplicationFiled: April 22, 2016Publication date: June 22, 2017Applicant: BRIGHAM YOUNG UNIVERSITYInventors: Paul B. Savage, Saurabh Shashikant Chitre, Kunal Arvind Varia, Hayley Ann Reece, Thomas E. Jacks, Ross A. Miller, Jared Lynn Randall
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Patent number: 9527883Abstract: Disclosed herein are methods of making ceragenin compounds for treating, preventing, or diagnosing diseases, disorders, or conditions associated with bacterial or viral infections, cancer, inflammation, and osteogenesis. Ceragenin compounds display broad spectrum antibacterial activity utilizing a mode of action similar to antimicrobial peptides, but without the high synthesis costs and susceptibility to proteolytic degradation. Ceragenin compounds reproduce the amphiphilic morphology found in many antimicrobial peptides and display potent and diverse biological activities, including anti-bacterial, anti-cancer, anti -inflammatory, bone growth promotion, and wound healing promotion.Type: GrantFiled: April 22, 2016Date of Patent: December 27, 2016Assignee: BRIGHAM YOUNG UNIVERSITYInventors: Paul B. Savage, Jared Lynn Randall
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Publication number: 20160311851Abstract: Disclosed herein are methods of making ceragnenin compounds for treating, preventing, or diagnosing diseases, disorders, or conditions associated with bacterial or viral infections, cancer, inflammation, and osteogenesis. Ceragenin compounds display broad-spectrum antibacterial activity utilizing a mode of action similar to antimicrobial peptides, but without the high synthesis costs and susceptibility to proteolytic degradation. Ceragenin compounds reproduce the amphiphilic morphology found in many antimicrobial peptides and display potent and diverse biological activities, including anti-bacterial, anti-cancer, anti-inflammatory, bone growth promotion, and wound healing promotion.Type: ApplicationFiled: April 22, 2016Publication date: October 27, 2016Applicant: BRIGHAM YOUNG UNIVERSITYInventors: Paul B. Savage, Thomas E. Jacks, Ross A. Miller, Andrew S. Thompson, Jared Lynn Randall
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Publication number: 20160311850Abstract: Disclosed herein are acid addition salts of cationic steroidal antimicrobials (“CSAs” or “ceragenins”) and methods of making the same. Particularly advantageous salt forms are identified, such as 1,5-naphthalenedisulfonic acid addition salts and sulfate addition salts. The acid addition salts may be formulated for treating subjects with ailments responsive to CSAs, including but not limited to treating bacterial infections. Accordingly, some embodiments include formulations and methods of administering acid addition salts of CSAs.Type: ApplicationFiled: April 22, 2016Publication date: October 27, 2016Applicant: BRIGHAM YOUNG UNIVERSITYInventors: Paul B. Savage, Saurabh Shashikant Chitre, Kunal Arvind Varia, Hayley Ann Reece, Thomas E. Jacks, Ross A. Miller, Jared Lynn Randall
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Publication number: 20160311852Abstract: Disclosed herein are methods of making ceragnenin compounds for treating, preventing, or diagnosing diseases, disorders, or conditions associated with bacterial or viral infections, cancer, inflammation, and osteogenesis. Ceragenin compounds display broad-spectrum antibacterial activity utilizing a mode of action similar to antimicrobial peptides, but without the high synthesis costs and susceptibility to proteolytic degradation. Ceragenin compounds reproduce the amphiphilic morphology found in many antimicrobial peptides and display potent and diverse biological activities, including anti-bacterial, anti-cancer, anti-inflammatory, bone growth promotion, and wound healing promotion.Type: ApplicationFiled: April 22, 2016Publication date: October 27, 2016Applicant: BRIGHAM YOUNG UNIVERSITYInventors: Paul B. Savage, Jared Lynn Randall
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Patent number: 7304084Abstract: 6-[(4,5-Dihydro-1H-imidazol-2-yl)amino-]-7-methyl-1H-benzimidazole-4-carbonitrile substantially free of 2,3,7-triamino-4,6-dimethyl-1,9-phenazinedicarbonitrile, and the anhydrous monoacetate salt thereof, are useful in the treatment of alpha-2 mediated disorders such as ocular hypertension.Type: GrantFiled: January 17, 2006Date of Patent: December 4, 2007Assignee: The Board of Regents of the University of NebraskaInventors: Jared Lynn Randall, Richard Alan Gibbs, Gregory Kent Bosch, Michael David Curtis, Li Sun, Nicholas Nikolaides
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Patent number: 6803469Abstract: The present invention relates to a process for preparing a quinolone antibiotic intermediate having the formula: wherein R is C1-C2 alkyl, C1-C2 fluoroalkyl, C2-C4 alkenyl, methoxy, chloro, or bromo; R1 is a unit selected from the group consisting of C1-C2 alkyl, C2-C3 alkenyl, C3-C5 cycloalkyl, and phenyl, each of which can be substituted by one or more fluorine atoms; said process comprising the step of cyclizing an admixture of quinolone precursors, said admixture comprising a 2-ethoxy substituted intermediate having the formula: in the presence of a silylating agent.Type: GrantFiled: July 30, 2003Date of Patent: October 12, 2004Assignee: The Procter & Gamble CompanyInventor: Jared Lynn Randall
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Publication number: 20040167194Abstract: 6-[(4,5-Dihydro-1H-imidazol-2-yl)amino-]-7-methyl-1H-benzimidazole-4-carbonitrile substantially free of 2,3,7-triamino-4,6-dimethyl-1,9-phenazinedicarbonitrile, and the anhydrous monoacetate salt thereof, are useful in the treatment of alpha-2 mediated disorders such as ocular hypertension.Type: ApplicationFiled: March 12, 2003Publication date: August 26, 2004Inventors: Jared Lynn Randall, Richard Alan Gibbs, Gregory Kent Bosch, Michael David Curtis, Li Sun, Nicholas Nikolaides
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Publication number: 20040063952Abstract: The present invention relates to a process for preparing a quinolone antibiotic intermediate having the formula: 1Type: ApplicationFiled: July 30, 2003Publication date: April 1, 2004Inventor: Jared Lynn Randall
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Patent number: 5801242Abstract: The present invention provides processes for making compounds of the structure(Q--L.sup.1)--L--(L.sup.2 --B)wherein(I) Q is a quinolone moiety;(II) B is a lactam moiety; and(III) L, L.sup.1, and L.sup.2 together comprise a linking moiety;comprising the steps of:(1) coupling a compound of Formula (III) with a lactam-containing compound to form an intermediate compound; and(2) cyclizing the intermediate by reaction with an organosilicon compound to give a compound of the formula (Q--L.sup.1)--L--(L.sup.2 --B).Preferably, the process additionally comprises a step prior to the coupling step, wherein protected forms of the compound of Formula (III) and the lactam compound are formed; and deprotection steps after the cyclization step, wherein the protecting groups are removed. Preferred antimicrobial compounds made by these processes are those where the beta-lactam moiety is a penem, a carbapenem, a cephem, or a carbacephem. Also preferred are those compounds where L.sup.1, L, and L.sup.Type: GrantFiled: November 12, 1997Date of Patent: September 1, 1998Assignee: The Procter & Gamble CompanyInventors: Jared Lynn Randall, Jane Ellen Godlewski
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Patent number: 5703231Abstract: The present invention provides a process for making a compound having a structure according to Formula (I) ##STR1## wherein A.sup.1, A.sup.2 and A.sup.3 are independently carbon or nitrogen and R.sup.1, R.sup.3, R.sup.4 and R.sup.6 are known quinolone substituents; and wherein one of R.sup.1, R.sup.3 or R.sup.6 may be a lactam-containing moiety;or a protected form, salt, pharmaceutically-acceptable salt, biohydrolyzable ester, or solvate thereof;the process comprising reacting one or more organosilicon compounds with a compound having a structure according to Formula (II) ##STR2## wherein A.sup.1, A.sup.2 and A.sup.3, R.sup.1, R.sup.3, R.sup.4 and R.sup.6 as described above; wherein one of R.sup.1, R.sup.3 or R.sup.6 may be a lactam-containing moiety; and X is a leaving group;or a protected form, salt, biohydrolyzable ester, or solvate thereof.Type: GrantFiled: November 14, 1996Date of Patent: December 30, 1997Assignee: The Procter & Gamble CompanyInventors: Jared Lynn Randall, Jane Ellen Godlewski