Abstract: Systems and methods for generating a movement model that requires less storage space than movement models of the prior art are disclosed. This movement model may be based on x-ray images of a patient and may be configured for estimating movement of organs within the patient during medical treatment. The movement model comprises at least two deformation fields associated with strong time points and a plurality of interpolation parameters associated with weak time points. In contrast with the prior art, the stored movement model does not include deformation fields associated with all time points. Because interpolation parameters rather than deformation fields are associated with the weak time points, the movement model requires less storage than movement models of the prior art. The stored movement model is optionally used to calculate interpolation fields that can be used to model movement of a patient.

Abstract: Various embodiments of the invention include systems and methods for adapting a movement model based on an image captured during radiation treatment of a patient. The movement model may, for example, be used in radiotherapy to treat lung cancer. The movement model is typically based on a series of images of a patient captured over a period of time. The movement model and/or one or images included therein may be used to generate a reference image of the patient. The reference image is compared with an image of the patient optionally captured during treatment. The result of this comparison is used to adapt the movement model to conditions during the treatment.

Abstract: Methods for developing and using treatment plans with improved modulation for radiation therapy are disclosed. The methods involve adding an extra component to the patient-related objective function in order to make the optimization algorithm used to develop the treatment plan arrive at a solution with increased modulation. The extra component may take many forms. For example, the user may specify that the treatment plan favor solutions using a range of monitor units. The present invention is particularly useful in conjunction with radiotherapy systems having multileaf collimators for beam shaping, and in connection with advanced radiotherapy techniques, such as IMRT and arc therapy.