Patents by Inventor Jaromir Vlach

Jaromir Vlach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrimidine derivatives for the treatment of viral infections
    Patent number: 11541050
    Abstract: This invention relates to pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections such as HCV or HBV.
    Type: Grant
    Filed: September 4, 2020
    Date of Patent: January 3, 2023
    Assignee: JANSSEN SCIENCES IRELAND UC
    Inventors: David Mc Gowan, Pierre Jean-Marie Bernard Raboisson, Werner Embrechts, Tim Hugo Maria Jonckers, Stefaan Julien Last, Serge Maria Aloysius Pieters, Jaromir Vlach
  • Polypeptides inhibiting CD40L
    Patent number: 11248055
    Abstract: The present invention relates to immunoglobulins that specifically bind CD40L and more in particular to polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. In particular, the immunoglobulins of the present invention inhibit the activity of CD40L and are safe.
    Type: Grant
    Filed: November 28, 2016
    Date of Patent: February 15, 2022
    Assignee: Ablynx N.V.
    Inventors: Els Pattyn, Ariëlla Van de Sompel, Peter Meerts, Marie-Ange Buyse, Maarten Dewilde, Gerald Beste, Jaromir Vlach, Jonathan Hsu
  • TLR7/8 ANTAGONISTS AND USES THEREOF
    Publication number: 20200316051
    Abstract: A treatment of disorders related to TLR7/8 overexpression or aberrant activation is provided. The disorder may include multiple sclerosis, Alzheimer's Disease, myositis, stroke, ischemia, CNS neuropathies, systemic lupus erythematosus, lupus nephritis, Sjogren's syndrome, Guillain-Barré syndrome, alcoholic hepatitis, non-alcoholic steatohepatitis, congenital heart block, autoimmune hepatitis, autoimmune pancreatitis, adult onset Still's disease, drug-induced neurological disorders, and substance addiction. A compound of Formula (I) is useful to treat such disorders.
    Type: Application
    Filed: June 17, 2020
    Publication date: October 8, 2020
    Inventors: Brian A. Sherer, Jaromir Vlach
  • Pyrimidine derivatives for the treatment of viral infections
    Patent number: 10780089
    Abstract: This invention relates to pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections such as HCV or HBV.
    Type: Grant
    Filed: August 2, 2019
    Date of Patent: September 22, 2020
    Assignee: JANSSEN SCIENCES IRELAND UC
    Inventors: David McGowan, Pierre Jean-Marie Bernard Raboisson, Werner Embrechts, Tim Hugo Maria Jonckers, Stefaan Julien Last, Serge Maria Aloysius Pieters, Jaromir Vlach
  • PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS
    Publication number: 20200061059
    Abstract: This invention relates to pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections such as HCV or HBV.
    Type: Application
    Filed: August 2, 2019
    Publication date: February 27, 2020
    Inventors: David McGowan, Pierre Jean-Marie Bernard Raboisson, Werner Embrechts, Tim Hugo Maria Jonckers, Stefaan Julien Last, Serge Maria Aloysius Pieters, Jaromir Vlach
  • METHODS FOR THE USE OF GALECTIN 3 BINDING PROTEIN DETECTED IN THE URINE FOR MONITORING THE SEVERITY AND PROGRESSION OF LUPUS NEPHRITIS
    Publication number: 20190310250
    Abstract: Embodiments of the present invention describe compositions and methods incorporating the measurement of LGALS3BP in the urine of patients diagnosed with lupus nephritis (LN) in order to monitor the severity and progression of said LN.
    Type: Application
    Filed: December 18, 2017
    Publication date: October 10, 2019
    Inventors: Lukas Shinji OKITSU, Jaromir VLACH, Nuruddeen Lewis, Julie DEMARTINO, Roberto BASSI, Wen-Rong LIE
  • Pyrimidine derivatives for the treatment of viral infections
    Patent number: 10420767
    Abstract: This invention relates to pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections such as HCV or HBV.
    Type: Grant
    Filed: January 10, 2018
    Date of Patent: September 24, 2019
    Assignee: Janssen Sciences Ireland UC
    Inventors: David McGowan, Pierre Jean-Marie Bernard Raboisson, Werner Embrechts, Tim Hugo Maria Jonckers, Stefaan Julien Last, Serge Maria Aloysius Pieters, Jaromir Vlach
  • Pyrimidine derivatives for the treatment of viral infections
    Patent number: 10272085
    Abstract: This invention relates to pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections such as HCV or HBV.
    Type: Grant
    Filed: July 13, 2016
    Date of Patent: April 30, 2019
    Assignee: Janssen Sciences Ireland UC
    Inventors: David McGowan, Pierre Jean-Marie Bernard Raboisson, Werner Embrechts, Tim Hugo Maria Jonckers, Stefaan Julien Last, Serge Maria Aloysius Pieters, Jaromir Vlach
  • POLYPEPTIDES INHIBITING CD40L
    Publication number: 20180355050
    Abstract: The present invention relates to immunoglobulins that specifically bind CD40L and more in particular to polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. In particular, the immunoglobulins of the present invention inhibit the activity of CD40L and are safe.
    Type: Application
    Filed: November 28, 2016
    Publication date: December 13, 2018
    Applicant: Ablynx N.V.
    Inventors: Els Pattyn, Ariëlla Van de Sompel, Peter Meerts, Marie-Ange Buyse, Maarten Dewilde, Gerald Beste, Jaromir Vlach, Jonathan Hsu
  • Methods for the Modulation of LGALS3BP to Treat Systemic Lupus Erythematosus
    Publication number: 20180251559
    Abstract: Embodiments of the present invention describe methods for modulating LGALS3BP and the use of antibodies to the same in the treatment of autoimmune diseases including systemic lupus erythematosus and lupus nephritis.
    Type: Application
    Filed: August 30, 2016
    Publication date: September 6, 2018
    Inventors: Julie DEMARTINO, Jonathan DERRY, Jaromir VLACH, Nuruddeen LEWIS, Melinda GENEST, Shinji OKITSU
  • PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS
    Publication number: 20180207155
    Abstract: This invention relates to pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections such as HCV or HBV.
    Type: Application
    Filed: January 10, 2018
    Publication date: July 26, 2018
    Inventors: David McGOWAN, Pierre Jean-Marie Bernard Raboisson, Werner Embrechts, Tim Hugo Maria Jonckers, Stefaan Julien Last, Serge Maria Aloysius Pieters, Jaromir Vlach
  • PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS
    Publication number: 20170239245
    Abstract: This invention relates to pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections such as HCV or HBV.
    Type: Application
    Filed: July 13, 2016
    Publication date: August 24, 2017
    Inventors: David Mc GOWAN, Pierre Jean-Marie Bernard Raboisson, Werner Embrechts, Tim Hugo Maria Jonckers, Stefaan Julien Last, Serge Maria Aloysius Pieters, Jaromir Vlach
  • Pyrimidine derivatives for the treatment of viral infections
    Patent number: 9422250
    Abstract: This invention relates to pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections such as HCV or HBV.
    Type: Grant
    Filed: April 10, 2012
    Date of Patent: August 23, 2016
    Assignee: Janssen Sciences Ireland UC
    Inventors: David Mc Gowan, Pierre Jean-Marie Bernard Raboisson, Werner Embrechts, Tim Hugo Maria Jonckers, Stefaan Julien Last, Serge Maria Aloysius Pieters, Jaromir Vlach
  • PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS
    Publication number: 20140045849
    Abstract: This invention relates to pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections such as HCV or HBV.
    Type: Application
    Filed: April 10, 2012
    Publication date: February 13, 2014
    Inventors: David McGowan, Pierr Jeane-Marie Bernar Raboisson, Werner Embrechts, Tim Hugo Maria Jonckers, Stefaan Julien Last, Serge Maria Aloysius Pieters, Jaromir Vlach
  • COMBINATIONS OF HCV PROTEASE INHIBITOR(S) AND CYP3A4 INHIBITOR(S), AND METHODS OF TREATMENT RELATED THERETO
    Publication number: 20100291034
    Abstract: Disclosed are medicaments, pharmaceutical compositions, pharmaceutical kits, and methods based on combinations comprising, separately or together: (a) a CYP3A4 inhibitor; and (b) a HCV protease inhibitor; for concurrent or consecutive administration in treating a human subject infected with HCV.
    Type: Application
    Filed: July 19, 2010
    Publication date: November 18, 2010
    Applicant: Schering Corporation
    Inventors: Robert O RALSTON, II, Julie M. Strizki, Jaromir Vlach, Samir K. Gupta, Edward M. O'Mara, JR., Anima Ghosal, Michelle A. Treitel, James F. McLeod, Ronald E. White
  • Screening assay for TLR7, TLR8 and TLR9 agonists and antagonists
    Patent number: 7498409
    Abstract: The present invention relates to novel screening methods for identifying agonists and antagonists of toll-like receptor (TLR) 7, TLR8 or TLR9. Methods are disclosed for identifying agonists and antagonists of TLR7, TLR8 or TLR9 using mutant TLR proteins containing deletions in one or more extracellular leucine rich regions (LRRs). Such agonists and antagonists have utility in the prevention, treatment and/or cure of various diseases and conditions, including cancer, virus infection, allergy, asthma, and chronic obstructive pulmonary disease (COPD).
    Type: Grant
    Filed: March 23, 2006
    Date of Patent: March 3, 2009
    Assignee: Schering Corporation
    Inventors: Jaromir Vlach, Uzma Ayesha Hasan, Sandra Dollet
  • Combinations of HCV protease inhibitor(s) and CYP3A4 inhibitor(s), and methods of treatment related thereto
    Publication number: 20070287664
    Abstract: Disclosed are medicaments, pharmaceutical compositions, pharmaceutical kits, and methods based on combinations comprising, separately or together: (a) a CYP3A4 inhibitor; and (b) a HCV protease inhibitor; for concurrent or consecutive administration in treating a human subject infected with HCV.
    Type: Application
    Filed: March 19, 2007
    Publication date: December 13, 2007
    Inventors: Robert Ralston, Julie Strizki, Jaromir Vlach, Samir Gupta, Edward O'Mara, Anima Ghosal, Michelle Treitel, James McLeod, Ronald White
  • Screening assay for TLR7, TLR8 and TLR9 agonists and antagonists
    Publication number: 20060269936
    Abstract: The present invention relates to novel screening methods for identifying agonists and antagonists of toll-like receptor (TLR) 7, TLR8 or TLR9. Methods are disclosed for identifying agonists and antagonists of TLR7, TLR8 or TLR9 using mutant TLR proteins containing deletions in one or more extracellular leucine rich regions (LRRs). Such agonists and antagonists have utility in the prevention, treatment and/or cure of various diseases and conditions, including cancer, virus infection, allergy, asthma, and chronic obstructive pulmonary disease (COPD).
    Type: Application
    Filed: March 23, 2006
    Publication date: November 30, 2006
    Inventors: Jaromir Vlach, Uzma Hasan, Sandra Dollet