Abstract: Disclosed herein are antibacterial combinations and compositions that are effective against Gram-negative bacteria. Also disclosed are uses of such combinations and compositions for inhibiting the growth and proliferation of Gram-negative bacteria and/or for killing Gram-negative bacteria and/or for treating a Gram-negative bacterial infection.

Abstract: The invention relates to phagemid vectors comprising i) a promoter operatively linked to a gene coding for a translational fusion between a peptide and a filamentous single strand DNA bacteriophage coat protein or a part thereof, which promoter is induced by expression of gene IV of a filamentous bacteriophage, ii) a replication origin derived from a filamentous single strand DNA bacteriophage, and iii) a plasmid replication origin. Further the invention relates to E. coli cells representing the phagemids. The phagemid vectors are suitable for phage display.

Abstract: Methods and compositions are provided for cloning and expression of serum opacity factor of Streptococcus pyogenes genes. The portion produced by the recombinant DNA techniques described herein may be employed in qualitative and quantitative testing for high density lipoprotein, as a fibronectin binding factor and for the regulation of high density lipoprotein in a mammal. The gene may further be employed as a molecular probe for accurate identification of opacity factors from various strains of Streptococcus pyogenes.