Patents by Inventor Jasodhara Ray
Jasodhara Ray has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7732201Abstract: A method for producing a neuroblast and a cellular composition comprising an enriched population of neuroblast cells is provided. Also disclosed are methods for identifying compositions which affect neuroblasts and for treating a subject with a neuronal disorder, and a culture system for the production and maintenance of neuroblasts.Type: GrantFiled: November 3, 2006Date of Patent: June 8, 2010Assignee: The Regents of the University of CaliforniaInventors: Fred H. Gage, Jasodhara Ray
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Publication number: 20070053887Abstract: A method for producing a neuroblast and a cellular composition comprising an enriched population of neuroblast cells is provided. Also disclosed are methods for identifying compositions which affect neuroblasts and for treating a subject with a neuronal disorder, and a culture system for the production and maintenance of neuroblasts.Type: ApplicationFiled: November 3, 2006Publication date: March 8, 2007Inventors: Fred Gage, Jasodhara Ray
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Publication number: 20050037495Abstract: Conditionally-immortalized human CNS progenitor cell lines are provided. Such cell lines, which may be clonal, may be used to generate neurons and/or astrocytes. Such cell lines and/or differentiated cells may be used for the development of therapeutic agents to prevent and treat a variety of CNS-related diseases. Such cell lines and/or differentiated cells may also be used in assays and for the general study of CNS cell development, death and abnormalities.Type: ApplicationFiled: March 29, 2004Publication date: February 17, 2005Inventors: Dinah Sah, Fred Gage, Jasodhara Ray
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Patent number: 6713247Abstract: Conditionally-immortalized human CNS progenitor cell lines are provided. Such cell lines, which may be clonal, may be used to generate neurons and/or astrocytes. Such cell lines and/or differentiated cells may be used for the development of therapeutic agents to prevent and treat a variety of CNS-related diseases. Such cell lines and/or differentiated cells may also be used in assays and for the general study of CNS cell development, death and abnormalities.Type: GrantFiled: September 3, 1996Date of Patent: March 30, 2004Assignee: Signal Pharmaceuticials, Inc.Inventors: Dinah W. Y. Sah, Fred H. Gage, Jasodhara Ray
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Publication number: 20040048373Abstract: A method for producing a neuroblast and a cellular composition comprising an enriched population of neuroblast cells is provided. Also disclosed are methods for identifying compositions which affect neuroblasts and for treating a subject with a neuronal disorder, and a culture system for the production and maintenance of neuroblasts.Type: ApplicationFiled: July 18, 2003Publication date: March 11, 2004Inventors: Fred H. Gage, Jasodhara Ray
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Patent number: 6680292Abstract: The present invention is directed to compositions comprising 1-(&bgr;-D-ribofuranosyl)-1H-1,2,4-triazole compounds and either endogenous or exogenous neurotrophic factors. Methods of using such compounds and compositions are also provided. In one aspect, the invention provides methods of using invention compositions and compounds to enhance neurite outgrowth, neuronal survival and neuronal proliferation in mammalian cells. In a preferred embodiment, a 1-(&bgr;-D-ribofuranosyl)1H-1,2,4-triazole compound is infused directly to a desired situs. In a more preferred embodiment the 1-(&bgr;-D-ribofuranosyl)-1,2,4-triazole compound is administered orally. In another aspect, the invention provides methods of treating a neurological disease in a mammal subject. In a further aspect, the invention provides methods of treating neuronal trauma in a mammal subject.Type: GrantFiled: September 24, 2001Date of Patent: January 20, 2004Assignee: The Salk Institute for Biological StudiesInventors: Roger C. Guillemin, Fred Harrison Gage, Jasodhara Ray
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Patent number: 6599695Abstract: A method for producing a neuroblast and a cellular composition comprising an enriched population of neuroblast cells is provided. Also disclosed are methods for identifying compositions which affect neuroblasts and for treating a subject with a neuronal disorder, and a culture system for the production and maintenance of neuroblasts.Type: GrantFiled: July 24, 2001Date of Patent: July 29, 2003Inventors: Fred H. Gage, Jasodhara Ray
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Publication number: 20030022261Abstract: The present invention is based on the discovery and isolation of a co-factor for trophic factors. It has been discovered that trophic factors require a co-factor to stimulate and/or potentiate the trophic factor activity and/or specificity. This was clearly identified in low density cells where trophic factors are unable, or at best, at minimal levels, able to proliferate undifferentiated cells without a co-factor. In a particular embodiment of the present invention, there is provided a composition comprising glycosylated cystatin C (CCg), an FGF co-factor that stimulates proliferation of neural and fibroblast associated undifferentiated cells. The N-glycosylation of cystatin C is required for its activity. Moreover, CCg acts in cooperation with basic fibroblast growth factor (FGF-2) to induce neural progenitor cell proliferation.Type: ApplicationFiled: August 20, 2002Publication date: January 30, 2003Inventors: Fred Harrison Gage, Philippe J. Taupin, Jasodhara Ray
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Patent number: 6436389Abstract: The present invention is based on the discovery and isolation of a co-factor for trophic factors. It has been discovered that trophic factors require a co-factor to stimulate and/or potentiate the trophic factor activity and/or specificity. This was clearly identified in low density cells where trophic factors are unable, or at best, at minimal levels, able to proliferate undifferentiated cells without a co-factor. In a particular embodiment of the present invention, there is provided a composition comprising glycosylated cystatin C, (CCg), an FGF co-factor that stimulates proliferation of neural and fibroblast associated undifferentiated cells. The N-glycosylation of cystatin C is required for its activity. Moreover, CCg acts in cooperation with basic fibroblast growth factor (FGF-2) to induce neural progenitor cell proliferation.Type: GrantFiled: December 13, 1999Date of Patent: August 20, 2002Assignee: The Salk Institute for Biological StudiesInventors: Fred Harrison Gage, Philippe J. Taupin, Jasodhara Ray
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Publication number: 20020039789Abstract: A method for producing a neuroblast and a cellular composition comprising an enriched population of neuroblast cells is provided. Also disclosed are methods for identifying compositions which affect neuroblasts and for treating a subject with a neuronal disorder, and a culture system for the production and maintenance of neuroblasts.Type: ApplicationFiled: July 24, 2001Publication date: April 4, 2002Inventors: Fred H. Gage, Jasodhara Ray
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Patent number: 6265175Abstract: A method for producing a neuroblast and a cellular composition comprising an enriched population of neuroblast cells is provided. Also disclosed are methods for identifying compositions which affect neuroblast and for treating a subject with a neuronal disorder, and a culture system for the production and maintenance of neuroblasts.Type: GrantFiled: June 27, 1997Date of Patent: July 24, 2001Assignee: The Regents of the University of CaliforniaInventors: Fred H. Gage, Jasodhara Ray
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Patent number: 6045807Abstract: A method for producing a neuroblast and a cellular composition comprising an enriched population of neuroblast cells is provided. Also disclosed are methods for identifying compositions which affect neuroblasts and for treating a subject with a neuronal disorder, and a culture system for the production and maintenance of neuroblasts.Type: GrantFiled: June 10, 1998Date of Patent: April 4, 2000Assignee: The Regents of the University of CaliforniaInventors: Fred H. Gage, Jasodhara Ray
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Patent number: 6020197Abstract: A method for producing a neuroblast and a cellular composition comprising an enriched population of neuroblast cells is provided. Also disclosed are methods for identifying compositions which affect neuroblasts and for treating a subject with a neuronal disorder, and a culture system for the production and maintenance of neuroblasts.Type: GrantFiled: April 24, 1998Date of Patent: February 1, 2000Assignee: The Regents of the University of CaliforniaInventors: Fred H. Gage, Jasodhara Ray
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Patent number: 6013521Abstract: A method for producing a neuroblast and a cellular composition comprising an enriched population of neuroblast cells is provided. Also disclosed are methods for identifying compositions which affect neuroblasts and for treating a subject with a neuronal disorder, and a culture system for the production and maintenance of neuroblasts.Type: GrantFiled: April 24, 1998Date of Patent: January 11, 2000Assignee: University of CaliforniaInventors: Fred H. Gage, Jasodhara Ray
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Patent number: 5770414Abstract: A novel regulatable retroviral vector in which the v-myc oncogene is driven by a tetracycline-controlled transactivator and a human cytomegalovirus minimal promoter fused to tet operator sequence useful for immortalization of adult neuronal progenitor cells is provided. Regulation of a heterologous Producer cell lines which produce high titers of the recombinant retrovirus are also provided.Type: GrantFiled: February 20, 1996Date of Patent: June 23, 1998Assignee: The Regents of the University of CaliforniaInventors: Fred H. Gage, Jasodhara Ray, Minoru Hoshimaru
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Patent number: 5766948Abstract: A method for producing a neuroblast and a cellular composition comprising an enriched population of neuroblast cells is provided. Also disclosed are methods for identifying compositions which affect neuroblasts and for treating a subject with a neuronal disorder, and a culture system for the production and maintenance of neuroblasts.Type: GrantFiled: November 3, 1993Date of Patent: June 16, 1998Assignee: The Regents of the University of CaliforniaInventors: Fred H. Gage, Jasodhara Ray
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Patent number: 5762926Abstract: Methods of genetically modifying donor cells by gene transfer for grafting into the central nervous system to treat defective, diseased or damaged cells are disclosed. The modified donor cells produce functional molecules that effect the recovery or improved function of cells in the CNS. Methods and vectors for carrying out gene transfer and grafting are described.Type: GrantFiled: June 5, 1995Date of Patent: June 9, 1998Assignee: The Regents of the University of CaliforniaInventors: Fred H. Gage, Malcolm Schinstine, Jasodhara Ray, Theodore Friedmann, Michael D. Kawaja, Michael B. Rosenberg, Jon A. Wolff
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Patent number: 5650148Abstract: Methods of genetically modifying donor cells by gene transfer for grafting into the central nervous system to treat defective, diseased or damaged cells are disclosed. The modified donor cells produce functional molecules that effect the recovery or improved function of cells in the CNS. Methods and vectors for carrying out gene transfer and grafting are described.Type: GrantFiled: March 10, 1994Date of Patent: July 22, 1997Assignee: The Regents of the University of CaliforniaInventors: Fred H. Gage, Theodore Friedmann, Michael B. Rosenberg, Jon A. Wolff, Malcolm Schinstine, Michael D. Kawaja, Jasodhara Ray