Patents by Inventor Jason A. Lotvin

Jason A. Lotvin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Separation of contaminants from Streptococcus pneumoniae polysaccharide by pH manipulation
    Publication number: 20060228381
    Abstract: A process for reducing the protein content and preserving the capsular polysaccharide content in a complex cellular Streptococcus pneumoniae lysate broth prior to purification is described. Utilizing pH reduction after cellular lysis has resulted in a purified polysaccharide that consistently meets the protein specification, and higher recovery yields of polysaccharide during the purification process.
    Type: Application
    Filed: March 31, 2006
    Publication date: October 12, 2006
    Applicant: Wyeth
    Inventors: Brian Bahler, Tsu-shun Lee, Jason Lotvin, Mark Ruppen, Pamela Charbonneau
  • Glycopeptide antibiotics
    Publication number: 20050288221
    Abstract: The invention provides compounds of formula Wherein R1, R2, R3, R4, R5, R6a, R6b, R6c, R6d, R6e and R7 are defined in the specification. These compounds are useful as antibiotic agents.
    Type: Application
    Filed: April 27, 2005
    Publication date: December 29, 2005
    Applicant: Wyeth Holdings Corporation
    Inventors: Jason Lotvin, Mark Ruppen
  • Cloning of the biosynthetic pathway for chlortetracycline and tetracycline formation and cosmids useful therein
    Patent number: 5866410
    Abstract: The present invention describes a purified and isolated nucleic acid molecule which encodes for the biosynthetic pathway of tetracycline, chlortetracycline or an analogue thereof. The invention relates to the isolation and cloning of the nucleic acid molecule in an isolated fragment from Streptomyces aureofaciens and the expression of the biosynthetic gene in a heterologous host such as Streptomyces lividans.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: February 2, 1999
    Assignee: American Cyanamid Company
    Inventors: Michael J. Ryan, Jason A. Lotvin, Nancy Strathy, Susan E. Fantini
  • Cloning of the biosynthetic pathway for chlortetracycline and tetracycline formation and cosmids useful therein
    Patent number: 5589385
    Abstract: The present invention describes a purified and isolated nucleic acid molecule which encodes for the biosynthetic pathway of tetracycline, chlortetracycline or an analogue thereof. The invention relates to the isolation and cloning of the nucleic acid molecule in an isolated fragment from Streptomyces aureofaciens and the expression of the biosynthetic gene in a heterologous host such as Streptomyces lividans.
    Type: Grant
    Filed: September 22, 1993
    Date of Patent: December 31, 1996
    Assignee: American Cyanamid Company
    Inventors: Michael J. Ryan, Jason A. Lotvin, Nancy Strathy, Susan E. Fantini
  • Colorimetric assay for detecting fungal cell envelope perturbations
    Patent number: 5168040
    Abstract: Methods of constructing and using gene expression systems to indicate the pertubation of fungal cell envelopes are provided. The recombinant genes produce indicator cleavage enzymes such as .beta.-galactosidase when galactose is able to enter the cell, despite the presence of glucose, through discontinuous cell envelopes. The indicator cleavage enzymes such as .beta.-galactosidase cleaves a colorimetric indicator placed in the media to produce an easily detected measurement of altered cell envelope permeability.
    Type: Grant
    Filed: March 16, 1988
    Date of Patent: December 1, 1992
    Assignee: Schering Corporation
    Inventors: Michael J. Ryan, Jason A. Lotvin, Elizabeth B. Smith, Karen J. Shaw