Abstract: Systems, methods and computer-readable media for evaluating business-critical criteria relating to exploring entity mobility/productivity opportunities are provided. A method according to the invention may include calculating a hierarchy of a plurality of decision elements regarding the opportunities. The calculating can include forming a matrix of values corresponding to the relative importance of each of the decision elements with respect to one another. The method can also include calculating a weighted composite score for each sub-process specified in each of the plurality of decision elements. The method may include compiling a favorability rating for each sub-process. The favorability rating for each sub-process may be based, at least in part, on the weighted composite score for each sub-process and the matrix of values corresponding to the relative importance of each of the decision elements with respect to one another.

Abstract: Systems, methods and computer-readable media for evaluating business-critical criteria relating to exploring entity mobility/productivity opportunities are provided. A method according to the invention may include calculating a hierarchy of a plurality of decision elements regarding the opportunities. The calculating can include forming a matrix of values corresponding to the relative importance of each of the decision elements with respect to one another. The method can also include calculating a weighted composite score for each sub-process specified in each of the plurality of decision elements. The method may include compiling a favorability rating for each sub-process. The favorability rating for each sub-process may be based, at least in part, on the weighted composite score for each sub-process and the matrix of values corresponding to the relative importance of each of the decision elements with respect to one another.

Abstract: Imidazo-quinoline, -pyridine, and -naphthyridine ring systems (particularly quinolines, tetrahydroquinolines, pyridines, 1,5-naphthyridines, 1,5-tetrahydronaphthyridines) substituted at the 1-position with a cyclic substituent, pharmaceutical compositions containing the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract: The present invention provides immunomodulatory compositions include an immune response modifier moiety coupled to a targeting moiety. In another aspect, the invention provides methods of providing targeted delivery of an IRM, generating a localized immune response, and treating a condition in a subject. Generally, the methods include administering to the subject an immunomodulatory composition that includes an immune response modifier moiety coupled to a targeting moiety that recognizes a delivery target.

Abstract: Pyrazolopyridin-4-amines, pyrazoloquinolin-4-amines, pyrazolonaphthyridin-4-amines, and 6,7,8,9-tetrahydropyrazoloquinolin-4-amines, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

Abstract: A process and intermediates for preparing 1H-imidazo[4,5-c]pyridin-4-amines are disclosed. The process includes providing a 7H-imidazo[4,5-c]tetrazolo[1,5-a]pyridine and converting a 7H-imidazo[4,5-c]tetrazolo[1,5-a]pyridine to a 1H-imidazo[4,5-c]pyridin-4-amine.