Abstract: The specification relates to a process for preparation of a compound of Formula (II), the process involving the step of reacting a compound of Formula (I), in a solvent, in the presence of a solid supported acid catalyst to form the compound of Formula (II), where R1, R2, R3, R4, R5 and are as described herein.

Abstract: Systems, methods, and apparatuses of the present disclosure generally relate to dissolvable plugs for separating fluids in a wellbore. A dissolvable plug includes a first end comprising a first fluid barrier. The first fluid barrier includes a polymer film. The dissolvable plug also includes a second end opposite to the first end. The second end comprises a second fluid barrier. The second fluid barrier comprises a polymer film. The dissolvable plug includes a solid structure made of a sand and salt mixture.

Abstract: Cement compositions and associated methods for cementing. An example method includes introducing a cement composition into a wellbore penetrating a subterranean formation, the cement composition comprising a composite material, a cement, and an aqueous fluid. The composite material comprises a monophase amorphous hydraulic binder material and a particulate core. The monophase amorphous hydraulic binder material coats the particulate core. The method further comprises allowing the cement composition to set in the wellbore.

Abstract: Cement compositions for use in subterranean wellbores that include a monophase amorphous hydraulic binder material (MAHBM). The MAHBM may include a plurality of particles having a silica core and an amorphous coating substantially surrounding the silica core. The coating may comprise a plurality of amorphous particles, such as ?-dicalcium silicate hydrate nanoparticles or microparticles. The MAHBM may be used as a strength retrogression mitigating additive in a cement composition or used as a high temperature cement.

Abstract: Cement compositions for primary cementing of well bores where a liquid mixture of pre-hydrated cementitious particles are combined with cement particles to form a cement composition.

Abstract: The present invention provides a compound of formula (I) or a salt thereof: (Formula (I)) wherein X, L, V, R1; R2, R3 and R4, are as defined herein. The claimed compounds inhibit the enzyme 11-hydroxysteroid dehydrogenase type 2 (11-HSD2) and as a result are useful in the treatment of hyperkalemia by preventing cortisol from being oxidised to cortisone and thus allowing it to occupy the mineralocorticoid receptor, thus stimulating potassium excretion.

Abstract: Systems, methods, and apparatuses of the present disclosure generally relate to dissolvable plugs for separating fluids in a wellbore. A dissolvable plug includes a first end comprising a first fluid barrier. The first fluid barrier includes a polymer film. The dissolvable plug also includes a second end opposite to the first end. The second end comprises a second fluid barrier. The second fluid barrier comprises a polymer film. The dissolvable plug includes a solid structure made of a sand and salt mixture.

Abstract: The present disclosure provides methods, compositions, and systems embodying cement compositions and the synergistic effect of lost circulation materials (LCMs) and fluid loss control additives (FLCAs) thereupon for cementing subterranean zones. A method of subterranean well cementing, comprising providing a cement composition comprising a hydraulic cement, a first FLCA, an LCM, and water, wherein the first FLCA comprises a water-soluble polymer with repeating units comprising a 5- to 6-membered cyclic amide; introducing the cement composition into a wellbore penetrating a subterranean formation, wherein inclusion of the first FLCA and the LCM in the cement composition fluid reduces fluid loss into the subterranean formation, wherein the subterranean formation has fractures with a width of from about 1 micron to about 800 microns, and wherein the subterranean formation has a permeability of about 1 milliDarcy to about 300 Darcy; and allowing the cement composition to set in the subterranean formation.

Abstract: The present technology is directed to fluorophore-containing compounds useful in the imaging of peripheral neurons as well as to proteins useful in the treatment (including management) of pain.

Abstract: Described herein are Tz/TCO-based pretargeting strategies using an Al[18F]-NOTA-labeled tetrazine radioligand. This imaging strategy enables delineation of cancer at earlier time points compared to other imaging strategies and further decreases the radiation dose to healthy tissues compared to directly labeled antibodies. Al-based 18F imaging of small molecules, such as tetrazine, has not been previously achieved due to the decomposition of tetrazine during radiofluorination. Radiofluorination is advantageous over other radiolabeling methods because, in addition to having a shorter half-life, 18F is more readily available to produce and therefore integrated into hospital workflows.

Abstract: The present disclosure is directed to compounds and methods for the treatment of disorders associated with fluid retention or salt overload, such as heart failure (in particular, congestive heart failure), chronic kidney disease, end-stage renal disease, liver disease, and peroxisome proliferator-activated receptor (PPAR) gamma agonist-induced fluid retention. The present disclosure is also directed to compounds and methods for the treatment of hypertension. The present disclosure is also directed to compounds and methods for the treatment of gastrointestinal tract disorders, including the treatment or reduction of pain associated with gastrointestinal tract disorders.

Abstract: A computer system generates a computer-guided personal care routine based at least in part on a digital model of a user's face. In an embodiment, a computer system generates the model based on one or more images or scans of the user's face, and generates a computer-guided personal care routine based on the model, environmental data (e.g., temperature data, humidity data, pollution data, UV radiation data), and user data. In an embodiment, a routine generated on this basis includes multiple steps to be carried out using a computer-controlled skin care device as well as user prompts related to execution of such steps that are configured to be presented in a user interface. In an embodiment, the computer-guided routine includes one or more operational settings (e.g., brush head speed, cleansing duration) for the computer-controlled skin care device that are automatically set at appropriate times according to the generated routine.

Abstract: A bulk dry cement may comprise a cement; a solid particle; and a liquid resin accelerator, wherein the liquid resin accelerator is disposed on a surface of the solid particle.

Abstract: The present disclosure provides methods, compositions, and systems embodying cement compositions and the synergistic effect of lost circulation materials (LCMs) and fluid loss control additives (FLCAs) thereupon for cementing subterranean zones. A method of subterranean well cementing, comprising providing a cement composition comprising a hydraulic cement, a first FLCA, an LCM, and water, wherein the first FLCA comprises a water-soluble polymer with repeating units comprising a 5- to 6-membered cyclic amide; introducing the cement composition into a wellbore penetrating a subterranean formation, wherein inclusion of the first FLCA and the LCM in the cement composition fluid reduces fluid loss into the subterranean formation, wherein the subterranean formation has fractures with a width of from about 1 micron to about 800 microns, and wherein the subterranean formation has a permeability of about 1 milliDarcy to about 300 Darcy; and allowing the cement composition to set in the subterranean formation.

Abstract: Expansive cement compositions for use in subterranean wellbores that include a monophase amorphous hydraulic binder material (MAHBM). The MAHBM may include a plurality of particles having a silica core and an amorphous coating substantially surrounding the silica core. The coating may comprise, for example, a plurality of amorphous ?-dicalcium silicate hydrate nanoparticles or microparticles. The MAHBM may be used as an expansion agent in a cement composition or used as an expansive cement by itself.

Abstract: A generative media pipeline automatically creates a personalized media program that is customized to reflect the specific viewing preferences of at least one individual user. The generative media pipeline obtains user data indicating the viewing preferences associated with the user and optionally the viewing context of the user. A recommendation service within the generative media pipeline provides a set of content options that includes various types of media content corresponding to the viewing preferences. A recipe service within the generative media pipeline obtains a recipe that defines the logical structure of the personalized media program. The recipe service populates the recipe by executing one or more video processing functions with some or all media content included in the content options. The recipe service thereby generates a logically structured and polished personalized media program that is individually tailored to reflect the specific preferences of the user.

Abstract: Cement compositions and associated methods for cementing. An example method includes introducing a cement composition into a wellbore penetrating a subterranean formation, the cement composition comprising a composite material, a cement, and an aqueous fluid. The composite material comprises a monophase amorphous hydraulic binder material and a particulate core. The monophase amorphous hydraulic binder material coats the particulate core. The method further comprises allowing the cement composition to set in the wellbore.

Abstract: A method may include introducing into a wellbore a resin-based sealant composition comprising: a resin comprising a cycloalkene; and a transition metal compound catalyst; and allowing the resin-based sealant composition to harden in the wellbore.

Abstract: A method of cementing may comprise: providing a bulk dry cement, wherein the bulk dry cement comprises a dry blend of cement and a solid resin accelerator, wherein the solid resin accelerator comprises a liquid resin accelerator on a solid particle; preparing a cement slurry comprising: the bulk dry cement; water; and a liquid hardenable resin component; and introducing the cement slurry into a wellbore.

Abstract: Cement compositions for use in subterranean wellbores that include a monophase amorphous hydraulic binder material (MAHBM). The MAHBM may include a plurality of particles having a silica core and an amorphous coating substantially surrounding the silica core. The coating may comprise a plurality of amorphous particles, such as ?-dicalcium silicate hydrate nanoparticles or microparticles. The MAHBM may be used as a strength retrogression mitigating additive in a cement composition or used as a high temperature cement.