Abstract: Among other things, the present disclosure provides designed oligonucleotides, compositions, and methods thereof. In some embodiments, provided oligonucleotide compositions provide improved single-stranded RNA interference and/or RNase H-mediated knockdown. Among other things, the present disclosure encompasses the recognition that structural elements of oligonucleotides, such as base sequence, chemical modifications (e.g., modifications of sugar, base, and/or internucleotidic linkages) or patterns thereof, conjugation with additional chemical moieties, and/or stereochemistry [e.g., stereochemistry of backbone chiral centers (chiral internucleotidic linkages)], and/or patterns thereof, can have significant impact on oligonucleotide properties and activities, e.g., RNA interference (RNAi) activity, stability, delivery, etc.

Abstract: A method includes obtaining a multi-utterance training sample that includes audio data characterizing utterances spoken by two or more different speakers and obtaining ground-truth speaker change intervals indicating time intervals in the audio data where speaker changes among the two or more different speakers occur. The method also includes processing the audio data to generate a sequence of predicted speaker change tokens using a sequence transduction model. For each corresponding predicted speaker change token, the method includes labeling the corresponding predicted speaker change token as correct when the predicted speaker change token overlaps with one of the ground-truth speaker change intervals. The method also includes determining a precision metric of the sequence transduction model based on a number of the predicted speaker change tokens labeled as correct and a total number of the predicted speaker change tokens in the sequence of predicted speaker change tokens.

Abstract: A multistage polymer is provided, having: acrylate rich stage comprising: (a) structural units of monomer selected from C1-22 alkyl (meth)acrylates and structural units of first carbosiloxane monomer of formula (I); and (b) carbosiloxane rich stage, comprising: structural units of second carbosiloxane monomer of formula (I); wherein a is 0 to 3; wherein d is 0 or 1; wherein R1 is selected from hydrogen, C1-10 alkyl group and aryl group; wherein R2 is selected from hydrogen and C1-10 alkyl group; wherein R8 is —O—Si(CH3)3 group; wherein Y is selected from formula (II), (III) and (IV); wherein R4 and R6 are selected from hydrogen and methyl group; wherein R3 and R5 are a C1-10 alkylene group; wherein R7 is C1-10 alkyl group; wherein b is 0 to 4 and wherein c is 0 or 1; and wherein the first and second carbosiloxane monomer of formula (I) are same or different.

Abstract: Personal care formulation is provided having multistage polymer, comprising: acrylate rich stage comprising: (a) structural units of monomer selected from C1-22 alkyl (meth)acrylates and structural units of first carbosiloxane monomer of formula (I); and (b) carbosiloxane rich stage, comprising: structural units of second carbosiloxane monomer of formula (I); wherein a is 0 to 3; wherein d is 0 or 1; wherein R1 is selected from hydrogen, C1-10 alkyl group and aryl group; wherein R2 is selected from hydrogen and C1-10 alkyl group; wherein R8 is —O—Si(CH3)3 group; wherein Y is selected from formula (II), (III) and (IV); wherein R4 and R6 are selected from hydrogen and methyl group; wherein R3 and R5 are C1-10 alkylene group; wherein R7 is C1-10 alkyl group; wherein b is 0 to 4 and wherein c is 0 or 1; and wherein the first and second carbosiloxane monomer of formula (I) are same or different.

Abstract: Among other things, the present disclosure relates to designed oligonucleotides, compositions, and methods thereof. In some embodiments, provided oligonucleotide compositions provide altered splicing of a transcript. In some embodiments, provided oligonucleotide compositions have low toxicity. In some embodiments, provided oligonucleotide compositions provide improved protein binding profiles. In some embodiments, provided oligonucleotide compositions have improved delivery. In some embodiments, provided oligonucleotide compositions have improved uptake. In some embodiments, the present disclosure provides methods for treatment of diseases using provided oligonucleotide compositions.

Abstract: Among other things, the present disclosure provides designed APOC3 oligonucleotides, compositions, and methods thereof. In some embodiments, provided oligonucleotide compositions provide improved single-stranded RNA interference and/or RNase H-mediated knockdown. Among other things, the present disclosure encompasses the recognition that structural elements of oligonucleotides, such as base sequence, chemical modifications (e.g., modifications of sugar, base, and/or internucleotidic linkages) or patterns thereof, conjugation with additional chemical moieties, and/or stereochemistry [e.g., stereochemistry of backbone chiral centers (chiral internucleotidic linkages)], and/or patterns thereof, can have significant impact on oligonucleotide properties and activities, e.g., RNA interference (RNAi) activity, stability, delivery, etc.

Abstract: Techniques related to parallel partitioning and coding mode selection for improved video coding throughput are discussed. Such techniques include performing parallel partitioning and coding mode selection for a lower-right coding unit of a first largest coding unit and an upper-left coding unit of a second largest coding unit to the right of the first largest coding unit and, immediately subsequent thereto, performing parallel partitioning and coding mode selection for a lower-left coding unit and an upper-right coding unit of the second largest coding unit.

Abstract: A recombinant protein comprising multiple multi-peptide sets includes first through fifth sequencing primers and first through fourth multi-peptide regions. The first multi-peptide region is between the first and the second sequencing primers. The second multi-peptide region is between the second and the third sequencing primers. The third multi-peptide region is between the third and the fourth sequencing primers. The fourth multi-peptide region is between the fourth and the fifth sequencing primers. In each of the multi-peptide regions, multiple functional peptides can be inserted, and manufacturing thereof can be done through expression of the recombinant protein, thereby significantly enhancing the concentrations of the functional peptides. With the combination of peptide having different functions, the recombinant protein product can provide more complete and more comprehensive functionality.

Abstract: A recombinant protein comprising multiple multi-peptide sets includes first through fifth sequencing primers and first through fourth multi-peptide regions. The first multi-peptide region is between the first and the second sequencing primers. The second multi-peptide region is between the second and the third sequencing primers. The third multi-peptide region is between the third and the fourth sequencing primers. The fourth multi-peptide region is between the fourth and the fifth sequencing primers. In each of the multi-peptide regions, multiple functional peptides can be inserted, and manufacturing thereof can be done through expression of the recombinant protein, thereby significantly enhancing the concentrations of the functional peptides. With the combination of peptide having different functions, the recombinant protein product can provide more complete and more comprehensive functionality.

Abstract: Embodiments of the present invention provide systems and methods for mounting an electrically-powered device to a ceiling or other supporting structure. The electrically-powered device can be, for example, a ceiling fan, a ceiling fan with a lighting fixture, or a lighting fixture.

Abstract: Embodiments of the present invention provide systems and methods for mounting an electrically-powered device to a ceiling or other supporting structure. The electrically-powered device can be, for example, a ceiling fan, a ceiling fan with a lighting fixture, or a lighting fixture.

Abstract: Techniques for secure remote access of computing resources are described herein. In some examples, when a client requests to access a computing resource, a computing service may generate a first password value for the computing resource and transmit the first password value to the client. The client may then generate and transmit key data for entry of the first password value back to the computing service. The client may generate and transmit the key data on the user's behalf, without requiring any activation or selection of keys by the user. Upon receiving the key data, the computing service may enter the first password value into the computing resource, thereby allowing the client to access the computing resource. The computing service may detect the accessing of the computing resource and may change the first password value to a second password value.

Abstract: Embodiments of the present invention provide systems and methods for mounting an electrically-powered device to a ceiling or other supporting structure. The electrically-powered device can be, for example, a ceiling fan, a ceiling fan with a lighting fixture, or a lighting fixture.

Abstract: A modular physiological training system including a torso, a rear skull portion, an airway assembly, and a front skull portion. The torso assembly representing a portion of a torso of a patient. The rear skull portion operably coupled to the torso assembly, and representing a rear portion of a patient's skull. The airway assembly representing an airway of the patient. The front skull portion including one or more coupling mechanisms, and representing a front portion of the patient's skull. The torso assembly and the rear skull portion configured to receive a portion of the airway assembly. The one or more coupling mechanisms of the front skull portion configured to operably couple the front skull portion to the airway assembly, and a front skull portion to the rear skull portion.

Abstract: A modular physiological training system including a torso, a rear skull portion, an airway assembly, and a front skull portion. The torso assembly representing a portion of a torso of a patient. The rear skull portion operably coupled to the torso assembly, and representing a rear portion of a patient's skull. The airway assembly representing an airway of the patient. The front skull portion including one or more coupling mechanisms, and representing a front portion of the patient's skull. The torso assembly and the rear skull portion configured to receive a portion of the airway assembly. The one or more coupling mechanisms of the front skull portion configured to operably couple the front skull portion to the airway assembly, and a front skull portion to the rear skull portion.

Abstract: A system for mounting an electrically-powered device such as a ceiling fan or other mounted fixture to supporting structure is disclosed. The system includes a mounting bracket having a receiving portion with a first electrical connector and a hangable structure with a mating member configured to be positioned against the receiving portion. The hangable structure includes a second electrical connector configured to become engaged with the first electrical connector as the hangable structure is moved downwardly into position to rest in proper alignment against the receiving portion. Positioning and alignment is accomplished without further manipulation of the hangable structure after engagement of the first and second electrical connectors. This system allows easier installation of the device by preventing gravity-influenced disengagement of the hangable structure from the mounting bracket once the electrical connection is established.

Abstract: Techniques for secure remote access of computing resources are described herein. In some examples, when a client requests to access a computing resource, a computing service may generate a first password value for the computing resource and transmit the first password value to the client. The client may then generate and transmit key data for entry of the first password value back to the computing service. The client may generate and transmit the key data on the user's behalf, without requiring any activation or selection of keys by the user. Upon receiving the key data, the computing service may enter the first password value into the computing resource, thereby allowing the client to access the computing resource. The computing service may detect the accessing of the computing resource and may change the first password value to a second password value.

Abstract: Aspects of the present invention disclose a method, computer program product, and system for determining whether an endpoint meets compliance standards. The method includes one or more processors receiving an endpoint certificate associated with an endpoint device that is requesting to access a resource, wherein the endpoint certificate includes a device fingerprint. The method further includes one or more processors determining compliance level of the endpoint device. The method further includes one or more processors validating credentials of the endpoint device. The method further includes one or more processors determining whether the endpoint device meets compliance standards based on the endpoint certificate, the determined compliance level, and the credentials of the endpoint device.

Abstract: Aspects of the present invention disclose a method, computer program product, and system for determining whether an endpoint meets compliance standards. The method includes one or more processors receiving an endpoint certificate associated with an endpoint device that is requesting to access a resource, wherein the endpoint certificate includes a device fingerprint. The method further includes one or more processors determining compliance level of the endpoint device. The method further includes one or more processors validating credentials of the endpoint device. The method further includes one or more processors determining whether the endpoint device meets compliance standards based on the endpoint certificate, the determined compliance level, and the credentials of the endpoint device.