Abstract: Methods and compositions for improving the specificity of genome-editing nucleases (e.g., RNA-guided CRISPR-Cas nucleases or engineered zinc fmger nucleases) and customizable DNA-binding domain fusion proteins (e.g., RNA-guided dead-Cas9, RNA-guided dead-Cpf1, or engineered zinc finger arrays fused to transcriptional regulatory domains) for use as research reagents, in gene drives, or as therapeutic agents.

Abstract: Methods and compositions for improving the genome-wide specificities of targeted base editing technologies.

Abstract: Systems, devices, and methods for encrypting genetic information are provided herein. Also provided herein are systems, devices, and methods for encrypting compressed genetic data, transmitting encrypted compressed genetic data, and receiving, storing, accessing encrypted compressed genetic data. In some cases, a user interface is in communication with a system or device provided herein.

Abstract: Non-limiting examples of the present disclosure describe proactive action by an intelligent personal assistant application/service to improve functionality of one or more applications. In one example, an intelligent personal assistant service may interface with a messaging application to analyze a message thread within the messaging application. The intelligent personal assistant service may analyze the message thread by evaluating context of message content within the message thread. Analysis of the message thread may occur proactively without requiring an explicit request for assistance from a user of a processing device. In response to the analyzing of the message thread, the intelligent personal assistant service may proactively provide a cue that includes content retrieved by the intelligent personal assistant service. An input may be received to include the cue within the message thread. In response to receiving the input, the cue may be displayed within the message thread.

Abstract: The present disclosure includes a core sample analysis system that includes a portable sampling device configured to be positioned adjacent to a subsurface core sample. The portable sample device includes a first module that includes a radiation source. Also, the portable sample device includes a second module that includes a detector that is configured to detect radiation emitted from the radiation source that reflects off of the subsurface core sample.

Abstract: Provided herein are fusion proteins useful in a bipartite cytosine base editor system comprising: (i) a first fusion protein comprising a non-R-loop-forming programmable DNA binding domain, preferably a transcription-activator-like effector (TALE) or zinc finger array (ZF), fused to a deaminase enzyme, or an active portion thereof, optionally with a linker therebetween, or (ii) a second fusion protein comprising an R-loop-forming Cas9 protein that lacks nuclease activity or is a nickase, but can interact with a guide RNA and target DNA, fused to a Uracil glycosylase inhibitor (UGI), optionally with a linker therebetween. Additionally, provided are methods for targeted deamination of one or more selected cytosines in a nucleic acid.

Abstract: A landing platform control system and methods used for refuel or recharge purposes by a fleet of unmanned aerial vehicles (UAVs) performing aerial surveys are disclosed. The system can include a plurality of landing platforms positioned at predetermined locations within the area of interest, each landing platform comprising a mount connecting the landing platform to a surface, a mount component for coupling a floor, a floor to support a UAV while docked at the landing platform, a cover enclosing the floor; a battery charger; and a communications interface. The floor can be rotated to clear any accumulated debris. The cover can be coupled to the floor. The cover can alternate between open and closed position via rotating along the same axis as the floor.

Abstract: A fluid source comprises a connector assembly for connecting a fluid supply device to either a first therapy device or to a second therapy device. A controller automatically provides a first configuration of a user interface associated with a first therapy when a supply connector is operatively coupled to the first therapy device and provides a second configuration of the user interface associated with a second therapy, different than the first configuration, when the supply connector is operatively coupled to the second therapy device. A hanger assembly is provided to hang the fluid source on different support structures. The fluid source also comprises a housing with a watershed region to shed liquid away from the user interface.

Abstract: A method and apparatus can be configured to initiate a request for connection with a user device. The method can include connecting to the user device. The method can also include connecting to a target device using an identifier of the proxy device. The user device is connected to the target device via the proxy device. An identifier of the user device is hidden from the target device. The target device identifies the user device using the identifier of the proxy device.

Abstract: A coated glass article includes a glass substrate and an anti-reflective coating formed over a first major surface of the glass substrate. The anti-reflective coating includes a color suppression interlayer and a first coating layer deposited over the color suppression interlayer. The first coating layer includes tin oxide and a dopant. The dopant includes antimony, molybdenum, or iron. A second coating layer is deposited over the first coating layer. The second coating layer includes an oxide of silicon. The coated glass article exhibits a total visible light transmittance of 70% or more and a film side visible light reflectance of less than 6.0%.

Abstract: A software update is downloaded from an update server responsive to an update trigger. A pre-installation bus traffic fingerprint is created responsive to completing the download. The software update is installed to the vehicle responsive to creating the pre-installation bus traffic fingerprint. A post-installation bus traffic fingerprint is created responsive to installing the software update. Success of the install is indicated to the update server based on comparing the pre-installation and post-installation bus traffic fingerprints.

Abstract: A device for compressing subject data, the device comprises a communication link, the communication link capable of receiving a set of subject data; a compression module, the compression module configured to apply a compression algorithm to the set of subject data, the compression algorithm compressing the set of subject data using a reference string of subject data; and a transmission module, the transmission module configured to transmit the compressed subject data. The device further comprising an encryption module for encrypting the subject data.

Abstract: A polymer suitable for use in a thin film hinge (living hinge) comprising from about 0.1 to about 5 weight % of a C4-8 comonomer and the balance ethylene, said composition having a density as determined according to ASTM D 792 from about 0.945 to about 0.965 g/cm3; a melt index as determined according to ASTM D1238 (2.16 kg/190° C.) from about 10 to about 20 g/10 min; a weight average molecular weight (Mw) from about 45,000 to about 55,000 g/mol; a polydispersity from about 2.5 to about 3.1 and when molded into a strip having a length of about 13 cm and gross thickness from about 50 to about 70 mil (about 1 to about 2 mm) and completely bent over end to end four times to create a thinned region or crease having a thickness from about 15 to about 30 mil (about 0.3 to about 0.7 mm) tested by bending and releasing the deformed thinned region of the strip through a radius of curvature from about 180 to about 190° about a rounded plate goes through not less than 500 cycles without breaking.

Abstract: Techniques for application launching in a multi-display device are described. In one or more implementations, an apparatus such as a mobile device includes multiple interconnected display devices. According to one or more implementations, techniques described herein enable application launching behavior to be determined based on context information. For instance, based on a determined context condition of a multi-display client device, an application launch behavior is determined and used to launch an application on the client device.

Abstract: An aircraft motor includes a bearing assembly including a first plurality of rotor alignment magnets; a magnet support structure fixedly mounted on a shaft of the motor in a spaced apart relation to the bearing assembly, the magnet support structure including a second plurality of rotor alignment magnets such that when the vertical thrust engine is disengaged, attraction between the first and second rotor alignment magnets causes the magnet support structure to rotate relative to the bearing assembly to an alignment position defined by the relative placement of north and south poles of the first and second plurality of rotor alignment magnets.

Abstract: The present disclosure provides immunotherapeutic compositions and methods for enhancing an immune response and for treating cancer or inflammatory conditions mediated by autoreactive B cells in a subject. In some aspects, multispecific antigen-binding constructs are provided that recognize at least one tumor antigen or B-lineage cell antigen and NKp30 and/or another activating NK receptor. In some aspects, multispecific antigen-binding constructs are provided that recognize at least two tumor antigens or two antigens expressed by B-lineage cells, NKp30, and another activating NK receptor. The multispecific antigen-binding constructs and methods disclosed herein can be used for the treatment of cancer, even a cancer characterized by a CD16 deficient microenvironment and/or characterized by target cells (e.g., cancer cells) having a low level of expression of the tumor antigen.

Abstract: This disclosure provides a patient support for supporting a patient. The patient support comprises a crib assembly comprising a support material with a cover assembly disposed over the crib assembly. The cover assembly defines a recess and comprising a patient support surface having an outer periphery. The patient support further comprises a connector assembly for connecting the patient support to a fluid source with the connector assembly comprising a connector with a plurality of ports. The assembly defines a three dimensional interior corner adjacent the recess in the cover assembly. The connector assembly is disposed in the recess of the cover assembly such that the plurality of ports of the connector are presented for connection to the fluid source at the three dimensional interior corner and inside the outer periphery of the patient support surface.

Abstract: Methods and devices for assessing, and treating patients having sympathetically mediated disease, involving augmented peripheral chemoreflex and heightened sympathetic tone by reducing chemosensor input to the nervous system via carotid body ablation. The methods may be performed using an ultrasound ablation catheter. The methods may also include imaging using at least one ultrasound imaging catheter.

Abstract: A vehicle includes a controller, programmed to responsive to receiving a command from a non-customer party, send an authorization request based on the command and a predefined vehicle parameter to a server; and responsive to receiving a signed command from the server, execute the signed command.

Abstract: A system and method are that includes a frame and a weapon mount on the frame that receives a weapon mock-up. The method includes setting up a trainer simulator including opening a transportable shipping container, wherein the transportable shipping container includes a coupled integrated common base frame and a universal mount tower. The method includes assembling a seat and pivoting the universal mount tower from a horizontal position to a vertical position wherein the universal mount tower auto-locks into position. The method includes delivering ground vehicle based weapon system training to a user using a continuum of human interface fidelities that includes a first, second and third fidelity, wherein the user is first delivered training at a first fidelity, and then at a second fidelity and then at a third fidelity. A system for a mission reconfigurable trainer simulation is also presented.