Abstract: The present invention relates to a new parallel interference cancellation (PIC) configuration where the PIC is implemented after the rake reception and multipath combining. In the invention disclosed, the regenerated interference contributions (functions of signature sequence cross-correlations) for multiuser detection (MUD) in a multipath radio channel are explicitly filtered through the estimated multipath channels, and stored. These stored quantities already contain the effect of the channel, and only need updating according to the rate of change of channel dynamics, and not the symbol period. During each symbol period, interference is computed from each interfering user to each desired user using current estimates of symbol decisions and the aforementioned interference contributions. The precomputation of the interference contributions, which are valid for a sequence of symbols, allows for extremely low complexity baseband processing in the receiver.