Patents by Inventor Jason S. Tedrow

Jason S. Tedrow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DIOL DESYMMETRIZATION BY NUCLEOPHILIC AROMATIC SUBSTITUTION
    Publication number: 20230365588
    Abstract: Provided herein are processes for synthesizing Mcl-1 inhibitors and intermediates such as compound Y that can be used to prepare them where the variable R1 is as defined herein. In particular, provided herein are processes for synthesizing compound A1, and salts or solvates thereof, compound A2, and salts and solvates thereof, and compound A3 and salts and solvates thereof.
    Type: Application
    Filed: September 1, 2021
    Publication date: November 16, 2023
    Applicant: AMGEN INC.
    Inventors: MATTHEW G. BEAVER, JOSEPH MICHAEL DENNIS, PETER DORNAN, STEVEN MENNEN, JASON S. TEDROW, NEIL F. LANGILLE, CAROLYN MICHELLE COHEN, ANDREAS RENE ROTHELI
  • Synthesis of Sulfonamide Intermediates
    Publication number: 20230357137
    Abstract: Provided herein are processes for synthesizing mcl-1 inhibitors and intermediates such as compound Z that can be used to prepare them. In particular, provided herein are processes for synthesizing compound A1, and salts or solvates thereof and compound A2, and salts and solvates thereof.
    Type: Application
    Filed: April 28, 2021
    Publication date: November 9, 2023
    Applicant: AMGEN INC.
    Inventors: Neil Fred LANGILLE, Jason S. TEDROW, Jonathan Vinh-Phu TRUONG, Robert Ronald MILBURN, Alessandro ARENA
  • SALT FORMS AND SOLVATES OF MCI-1 ANTAGONISTS
    Publication number: 20230312602
    Abstract: Disclosed herein are salt and solvate forms of. (1S,3?R,6?R,7?S,8?E,11?S,12?R)-6-chloro-7?-methoxy-11?,12?-dimethyl-3,4-dihydro-2H,15?H-spiro[naphthalene-1,22?-[20]oxa[13]thia[1,14]diazatetracyclo[14.7.2.03,6.019,24]pentacosa[8,16,18,24]tetraen]-15?-one 13?,13?-dioxide (AMG 176): such as crystalline salt and solvate forms thereof. Also disclosed are methods of making the salt and solvate forms, and methods of treating diseases and disorders with the salt and solvate forms.
    Type: Application
    Filed: April 5, 2023
    Publication date: October 5, 2023
    Inventors: Henry Morrison, Jason S. Tedrow, Stephan D. Parent, Courtney Johnson, Travis Houston, Melanie Bevill
  • Ring Closing Synthesis of Macrocyclic MCL-1 Inhibitor Intermediates
    Publication number: 20230167130
    Abstract: Provided herein are processes for synthesizing Mcl-1 inhibitors and intermediates such as compound F that can be used to prepare them where the variable PG is as defined herein. In particular, provided herein are processes for synthesizing compound A1, and salts or solvates thereof and compound A2, and salts and solvates thereof.
    Type: Application
    Filed: May 5, 2021
    Publication date: June 1, 2023
    Applicant: AMGEN INC.
    Inventors: Austin G. SMITH, Jason S. TEDROW, Gabrielle ST-PIERRE, Oliver Ralf THIEL, Liang HUANG, Philipp C. ROOSEN, John T. COLYER, Kyle D. BAUCOM, Ari ERICSON, Matthew G. BEAVER, Rahul P. SANGODKAR, Michael A. LOVETTE, Robert Ronald MILBURN, Alan H. CHERNEY, Sheng CUI
  • Synthesis of vinylic alcohol intermediates
    Publication number: 20230136910
    Abstract: Provided herein are processes for synthesizing intermediates useful in preparing Mcl-1 inhibitors. In particular, provided herein are processes for synthesizing compound (E), wherein R1 is described herein. Compound (E) can be useful in synthesizing compound (A1), or a salt or solvate thereof, and compound (A2), or a salt of solvate thereof.
    Type: Application
    Filed: April 28, 2021
    Publication date: May 4, 2023
    Applicant: AMGEN INC.
    Inventors: Robert P. FARRELL, Jason S. TEDROW
  • Crystalline N-(4-(4-aminothieno[2,3-d]pyrimidin-5-yl)phenyl)-N?-(2-fluoro-5-(trifluoromethyl)phenyl)urea ethanolate
    Patent number: 7745448
    Abstract: A crystalline N-(4-(4-aminothieno[2,3 -d]pyrimidin-5-yl)phenyl)-N?-(2-fluoro-5-(trifluoromethyl)phenyl)urea ethanolate characterized in the monoclinic crystal system and P21/n space group, when measured with radiation at 0.7107 ?, by lattice parameters a, b and c of 5.0318 ?±0.006 ?, 23.684 ?±0.002 ? and 18.877 ?±0.002 ?, respectively, and ? of 90.703±0.003, ways to make it, compositions comprising it, and methods of treatment using it are disclosed.
    Type: Grant
    Filed: December 20, 2006
    Date of Patent: June 29, 2010
    Assignee: Abbott Laboratories Inc.
    Inventors: Sean M. Mellican, Cathie L. Linton, Jianzhang Mei, Jason S. Tedrow, Nahathai Charukamnoetkanok, Rodger Henry
  • Crystalline N-(4-(4-ammoniumthieno[2,3-d]pyrimidin-5-yl)phenyl)-N?-(2-fluoro-5-(trifluoromethyl)phenyl)urea benzenesulfonate
    Patent number: 7745622
    Abstract: A crystalline N-(4-(4-aminothieno[2,3-d]pyrimidin-5-yl)phenyl)-N?-(2-fluoro-5-(trifluoromethyl)phenyl)urea benzenesulfonate characterized in the triclinic crystal system and P-1 space group, when measured with radiation at 0.7107 ?, by lattice parameters a, b and c of 7.800 ?±0.001 ?, 13.406 ?±0.002 ? and 13.554 ?±0.002 ?, respectively and ?, ? and ? of 67.155±0.002, 79.724°±0.002° and 84.067±0.002, respectively, ways to make it, compositions comprising it, and methods of treatment using it are disclosed.
    Type: Grant
    Filed: December 20, 2006
    Date of Patent: June 29, 2010
    Assignee: Abbott Laboratories, Inc.
    Inventors: Sean M. Mellican, Cathie L. Linton, Jianzhang Mei, Jason S. Tedrow, Nahathai Charukamnoetkanok, Rodger Henry
  • Crystalline N-(4-(4-aminothieno[2,3-d]pyrimidin-5-yl)phenyl)-N'-(2-fluoro-5-(trifluoromethyl)phenyl)urea hydrochloride
    Publication number: 20090270424
    Abstract: A crystalline N-(4-(4-aminothieno[2,3-d]pyrimidin-5-yl)phenyl)-N?-[2-fluoro-5-(trifluoromethyl)phenyl)urea hydrochloride, ways to make it, compositions comprising it, and methods of treatment using it are disclosed.
    Type: Application
    Filed: December 20, 2006
    Publication date: October 29, 2009
    Inventors: Sean M. Mellican, Cathie L. Linton, Jianzhang Mei, Jason S. Tedrow, Nahathai Charukamnoetkanok
  • Sulfonamides having antiangiogenic and anticancer activity
    Patent number: 7491718
    Abstract: Compounds having methionine aminopeptidase-2 inhibitory (MetAP2) are described. Also described are pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, methods of inhibiting angiogenesis, and methods of treating cancer.
    Type: Grant
    Filed: October 8, 2003
    Date of Patent: February 17, 2009
    Assignee: Abbott Laboratories
    Inventors: Kenneth M. Comess, Scott A. Erickson, Jack Henkin, Douglas M. Kalvin, Megumi Kawai, Ki H. Kim, Nwe Y. BaMaung, Chang Hoon Park, George S. Sheppard, Anil Vasudevan, Jieyi Wang, David M. Barnes, Steve D. Fidanze, Lawrence Kolaczkowski, Robert A. Mantei, David C. Park, William J. Sanders, Jason S. Tedrow, Gary T. Wang
  • Sulfonamides having antiangiogenic and anticancer activity
    Publication number: 20040167128
    Abstract: Compounds having methionine aminopeptidase-2 inhibitory (MetAP2) are described. Also described are pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, methods of inhibiting angiogenesis, and methods of treating cancer.
    Type: Application
    Filed: October 8, 2003
    Publication date: August 26, 2004
    Inventors: Kenneth M. Comess, Scott A. Erickson, Jack Henkin, Douglas M. Kalvin, Megumi Kawai, Ki H. Kim, Nwe Y. BaMaung, Chang Hoon Park, George S. Sheppard, Anil Vasudevan, Jieyi Wang, David M. Barnes, Steve D. Fidanze, Lawrence Kolaczkowski, Robert A. Mantei, David C. Park, William J. Sanders, Jason S. Tedrow, Gary T. Wang
  • Sulfonamides having antiangiogenic and anticancer activity
    Publication number: 20040157836
    Abstract: Compounds having methionine aminopeptidase-2 inhibitory (MetAP2) are described. Also described are pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, methods of inhibiting angiogenesis, and methods of treating cancer.
    Type: Application
    Filed: September 23, 2003
    Publication date: August 12, 2004
    Inventors: Kenneth M. Comess, Scott A. Erickson, Jack Henkin, Douglas M. Kalvin, Megumi Kawai, Ki H. Kim, Nwe Y. BaMaung, Chang Hoon Park, George S. Sheppard, Anil Vasudevan, Jieyi Wang, David M. Barnes, Steve D. Fidanze, Lawrence Kolaczkowski, Robert A. Mantei, David C. Park, William J. Sanders, Jason S. Tedrow, Gary T. Wang