Abstract: Generating a synthetic longitudinal dataset includes identifying subsequence patterns in records defining event sequences for patients. Feature vectors are determined, each characterizing a corresponding one of the records, based on the subsequence patterns. The feature vectors are embedded in a lower dimension space. A seed record is iteratively selected from among the records and in each iteration: subsequence patterns are identified in a subset of the records. Instances of subsequence patterns in the seed record are replaced with instances of similar subsequence patterns identified in the subset of the records to form a modified seed record. The iterations are repeated until all of the records have been selected as the seed record. The modified seed records are combined to form the synthetic dataset.

Abstract: A method of controlling an electromechanical brake system. The method comprises measuring a voltage of a motor, measuring a current of the motor, and estimating a position of a component of the electromechanical brake system based on the voltage and the current. The method comprises estimating a force imposed by the component based on the voltage and the current, and estimating a hydraulic pressure associated with a hydraulic brake system. In an apply operation, the force of the component is corrected based on the hydraulic pressure. In a release operation, the position of the component is corrected based on the hydraulic pressure.

Abstract: In one aspect, the invention relates to an immunogenic composition that includes a mutant Clostridium difficile toxin A and/or a mutant Clostridium difficile toxin B. The mutant toxin may include a glucosyltransferase domain having at least one mutation and a cysteine protease domain having at least one mutation, relative to the corresponding wild-type C. difficile toxin. The mutant toxins may include at least one amino acid that is chemically crosslinked. In another aspect, the invention relates to methods and compositions for use in culturing Clostridium difficile and in producing C. difficile toxins.

Abstract: The present invention encompasses compounds of formula (I) wherein R1a, R1b, R2a, R2b, Z, R3 to R5, A, p, U, V, W, L and E have the meanings given in the claims and specification, their use as inhibitors of mutant Ras family proteins, pharmaceutical compositions and preparations containing such compounds and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.

Abstract: In various examples, a table recognition model receives an image of a table and generates, using a first encoder of the table recognition machine learning model, an image feature vector including features extracted from the image of the table; generates, using a first decoder of the table recognition machine learning model and the image feature vector, a set of coordinates within the image representing rows and columns associated with the table, and generates, using a second decoder of the table recognition machine learning model and the image feature vector, a set of bounding boxes and semantic features associated with cells the table, then determines, using a third decoder of the table recognition machine learning model, a table structure associated with the table using the image feature vector, the set of coordinates, the set of bounding boxes, and the semantic features.

Abstract: Systems and methods for image processing are described. Embodiments of the present disclosure receive an image having a plurality of object instances; encode the image to obtain image features; decode the image features to obtain object features; generate object detection information based on the object features using an object detection branch, wherein the object detection branch is trained based on a first training set using a detection loss; generate semantic segmentation information based on the object features using a semantic segmentation branch, wherein the semantic segmentation branch is trained based on a second training set different from the first training set using a semantic segmentation loss; and combine the object detection information and the semantic segmentation information to obtain panoptic segmentation information that indicates which pixels of the image correspond to each of the plurality of object instances.

Abstract: Techniques are described by which a network management system (NMS) provides a common user interface (UI) to enable a user to collectively configure network devices to establish an EVPN topology. For example, an NMS is configured to: generate data representative of a common UI comprising UI elements representing a plurality of network devices to be configured in an EVPN topology; receive, via the common UI, an indication of a user input selecting one or more of the UI elements representing selected network devices; generate UI elements representing a plurality of ports of the selected network devices; receive, via the common UI, an indication of a user input selecting the UI elements representing one or more selected ports; and generate, based on the one or more selected network devices and one or more selected ports, topology relationship information of the one or more selected devices to establish the EVPN topology.

Abstract: Lateral flow immunoassays that reliably detect human antibodies, including IgG and/or IgM antibodies, specific for severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) are described herein. Devices, methods and kits for analysis of samples, such as liquid blood, serum or plasma, for the presence of human antibodies, such as IgG and/or IgM antibodies, specific for SARS CoV-2 proteins, such as SARS CoV-2 N and/or S proteins are provided.

Abstract: Techniques are described by which a network management system (NMS) provides a common user interface (UI) to enable a user to collectively configure network devices to establish an EVPN topology. For example, an NMS is configured to: generate data representative of a common UI comprising UI elements representing a plurality of network devices to be configured in an EVPN topology; receive, via the common UI, an indication of a user input selecting one or more of the UI elements representing selected network devices; generate UI elements representing a plurality of ports of the selected network devices; receive, via the common UI, an indication of a user input selecting the UI elements representing one or more selected ports; and generate, based on the one or more selected network devices and one or more selected ports, topology relationship information of the one or more selected devices to establish the EVPN topology.

Abstract: Techniques are described by which a network management system (NMS) provides a common user interface (UI) to enable a user to collectively configure network devices to establish an EVPN topology. For example, an NMS is configured to: generate data representative of a common UI comprising UI elements representing a plurality of network devices to be configured in an EVPN topology; receive, via the common UI, an indication of a user input selecting one or more of the UI elements representing selected network devices; generate UI elements representing a plurality of ports of the selected network devices; receive, via the common UI, an indication of a user input selecting the UI elements representing one or more selected ports; and generate, based on the one or more selected network devices and one or more selected ports, topology relationship information of the one or more selected devices to establish the EVPN topology.

Abstract: A connectable locking plate assembly comprises a locking plate unit, a connection unit, and a locking component. The locking plate unit comprises multiple interconnecting fixing parts. The connection unit comprises multiple interconnecting positioning parts, and at least one of the positioning parts has an assembly recess. One of the fixing parts is inserted into the assembly recess. The locking component is mounted through the screw connecting hole on the connection unit and is screwed into the screw setting hole of the locking plate unit. Therefore, the connectable locking plate assembly can be assembled into an appropriate structure by assembling the locking plate unit, the connection unit, and the locking component to meet the sizes and outer shapes of the bones at the fracture site. Therefore, the assembly can increase the fitting and fixing effect to the bones, and can enhance convenience during assembling.

Abstract: A human implant includes at least one osteoconductive scaffold and at least one main carrier. The at least one osteoconductive scaffold is made of a metal material, is manufactured by 3D printing, and has at least one connecting portion, at least one separation element, and a proliferation portion. The at least one connecting portion is porous. The at least one separation element is disposed on one of two sides of the at least one connecting portion. The proliferation portion is disposed on one of two sides of the at least one separation element away from the at least one connecting portion, wherein osteoblasts proliferate in the proliferation portion. The at least one main carrier is made of a medical macromolecular material and is mounted to the at least one connecting portion being porous, such that the at least one main carrier is mounted to the at least one osteoconductive scaffold.

Abstract: An integrated circuit may include a pillar of semiconductor material, a field effect transistor having a channel that is formed in the pillar of semiconductor material, and two or more memory cells, stacked vertically on top of the field effect transistor, and having channels that are formed in the pillar semiconductor of material.

Abstract: Disclosed are various embodiments for an automated service agent. Natural language inputs are obtained from a client. The natural language inputs and other data are input to machine learning models to identify intents reflected in the natural language inputs. A state in a workflow is updated to reflect the identified intents. Responses may be communicated to the client to further progress in the workflow.

Abstract: An integrated circuit may include a pillar of semiconductor material, a field effect transistor having a channel that is formed in the pillar of semiconductor material, and two or more memory cells, stacked vertically on top of the field effect transistor, and having channels that are formed in the pillar semiconductor of material.

Abstract: A hollow-channel memory device comprises a source layer, a first hollow-channel pillar structure formed on the source layer, and a second hollow-channel pillar structure formed on the first hollow-channel pillar structure. The first hollow-channel pillar structure comprises a first thin channel and the second hollow-channel pillar structure comprises a second thin channel that is in contact with the first thin channel. In one exemplary embodiment, the first thin channel comprises a first level of doping; and the second thin channel comprises a second level of doping that is different from the first level of doping. In another exemplary embodiment, the first and second levels of doping are the same.

Abstract: A hollow-channel memory device comprises a source layer, a first hollow-channel pillar structure formed on the source layer, and a second hollow-channel pillar structure formed on the first hollow-channel pillar structure. The first hollow-channel pillar structure comprises a first thin channel and the second hollow-channel pillar structure comprises a second thin channel that is in contact with the first thin channel. In one exemplary embodiment, the first thin channel comprises a first level of doping; and the second thin channel comprises a second level of doping that is different from the first level of doping. In another exemplary embodiment, the first and second levels of doping are the same.

Abstract: In an embodiment of the present invention is provided a varactor comprising a substrate, a plurality of bottom electrodes positioned on a surface of the substrate separated to form a gap therein, a tunable dielectric material positioned on the surface of the substrate and within the gap, the tunable dielectric at least partially overlaying the plurality of electrodes, and a top electrode in contact with the tunable dielectric.

Abstract: A hollow-channel memory device comprises a source layer, a first hollow-channel pillar structure formed on the source layer, and a second hollow-channel pillar structure formed on the first hollow-channel pillar structure. The first hollow-channel pillar structure comprises a first thin channel and the second hollow-channel pillar structure comprises a second thin channel that is in contact with the first thin channel. In one exemplary embodiment, the first thin channel comprises a first level of doping; and the second thin channel comprises a second level of doping that is different from the first level of doping. In another exemplary embodiment, the first and second levels of doping are the same.

Abstract: A hollow-channel memory device comprises a source layer, a first hollow-channel pillar structure formed on the source layer, and a second hollow-channel pillar structure formed on the first hollow-channel pillar structure. The first hollow-channel pillar structure comprises a first thin channel and the second hollow-channel pillar structure comprises a second thin channel that is in contact with the first thin channel. In one exemplary embodiment, the first thin channel comprises a first level of doping; and the second thin channel comprises a second level of doping that is different from the first level of doping. In another exemplary embodiment, the first and second levels of doping are the same.