Patents by Inventor Jason T. LOWE

Jason T. LOWE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS AND USES THEREOF
    Publication number: 20240166668
    Abstract: The present disclosure features compounds useful for the treatment of BAF complex-related disorders.
    Type: Application
    Filed: November 27, 2023
    Publication date: May 23, 2024
    Inventors: Sabine K. RUPPEL, Zhaoxia Yang, Jason T. LOWE, Johannes H. VOIGT
  • BRD9 DEGRADERS AND USES THEREOF
    Publication number: 20240150348
    Abstract: The present invention relates to methods and compositions for the treatment of BAF-related disorders such as cancers and viral infections.
    Type: Application
    Filed: August 25, 2023
    Publication date: May 9, 2024
    Inventors: Sabine K. RUPPEL, Zhaoxia YANG, Jason T. LOWE, Johannes H. VOIGT, Matthew NETHERTON, Francois BRUCELLE
  • METHODS AND COMPOUNDS FOR TREATING DISORDERS
    Publication number: 20240150328
    Abstract: The present invention relates to methods and compositions for the treatment of BAF-related disorders such as cancers and viral infections.
    Type: Application
    Filed: August 23, 2023
    Publication date: May 9, 2024
    Inventors: Qianhe ZHOU, Michael BOCKER, David Simon MILLAN, Ho Man CHAN, Luis SOARES, Matthew NETHERTON, Sabine K. RUPPEL, Zhaoxia YANG, Jason T. LOWE, Francois BRUCELLE
  • COMPOUNDS THAT PARTICIPATE IN COOPERATIVE BINDING AND USES THEREOF
    Publication number: 20240139185
    Abstract: The disclosure features macrocyclic compounds, alone and in combination with other therapeutic agents, as well as pharmaceutical compositions and protein complexes thereof, capable of modulating biological processes including RAS and RAS-RAF inhibition, and their uses in the treatment of cancers.
    Type: Application
    Filed: March 16, 2023
    Publication date: May 2, 2024
    Inventors: Meizhong JIN, Nicholas Perl, Anna Kohlmann, Ning Yin, Jason T. Lowe, Jae Young Ahn, Mark Joseph Mulvihill, Elena S. Koltun, Adrian L. Gill
  • Methods of producing patient-specific anti-cancer therapeutics and methods of treatment therefor
    Patent number: 11971409
    Abstract: A method of preparing an antibody therapeutic is provided comprising: (a) providing a dissociated cell sample from at least one solid tumor sample obtained from a patient; (b) loading the dissociated cell sample into a microfluidic device having a flow region and at least one isolation region fluidically connected to the flow region; (c) moving at least one B cell from the dissociated cell sample into at least one isolation region in the microfluidic device, thereby obtaining at least one isolated B cell; and (d) using the microfluidic device to identify at least one B cell that produces antibodies capable of binding to cancer cells. The cancer cells can be the patient's own cancer cells. Also provided are methods of treating patients, methods of labeling or detecting cancer, engineered T or NK cells comprising antibodies or fragments thereof, and engineered antibody constructs.
    Type: Grant
    Filed: June 4, 2020
    Date of Patent: April 30, 2024
    Assignee: Bruker Cellular Analysis, Inc.
    Inventors: Kevin T. Chapman, Mark P. White, Xiaohua Wang, Minha Park, Guido K. Stadler, Randall D. Lowe, Jr., Xiao Guan Radstrom, Jason M. McEwen, Gang F. Wang, George L. Fox, Peggy A. Radel
  • Certain pladienolide compounds and methods of use
    Patent number: 11926619
    Abstract: The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.
    Type: Grant
    Filed: April 8, 2019
    Date of Patent: March 12, 2024
    Assignee: Eisai R & D Management Co., Ltd.
    Inventors: Gregg F. Keaney, John Wang, Baudouin Gerard, Kenzo Arai, Xiang Liu, Guo Zhu Zheng, Kazunobu Kira, Lisa A. Marcaurelle, Marta Nevalainen, Ming-Hong Hao, Morgan Welzel O'Shea, Parcharee Tivitmahaisoon, Sudeep Prajapati, Tuoping Luo, Nicholas C. Gearhart, Jason T. Lowe, Yoshihiko Kotake, Satoshi Nagao, Regina Mikie Kanada Sonobe, Masayuki Miyano, Norio Murai, Andrew Cook, Shelby Ellery, Atsushi Endo, James Palacino, Dominic Reynolds
  • COMPOUNDS AND USES THEREOF
    Publication number: 20240067642
    Abstract: The present invention relates to compositions and methods for the treatment of BAF-related disorders, such as cancers and viral infections.
    Type: Application
    Filed: June 29, 2023
    Publication date: February 29, 2024
    Inventors: Sabine K. RUPPEL, Zhaoxia YANG, Jason T. LOWE, Johannes H. VOIGT, Matthew NETHERTON
  • COMPOUNDS AND USES THEREOF
    Publication number: 20240002382
    Abstract: The present invention relates to compositions and methods for the treatment of BAF-related disorders, such as cancers and viral infections.
    Type: Application
    Filed: June 29, 2023
    Publication date: January 4, 2024
    Inventors: Sabine K. RUPPEL, Zhaoxia YANG, Jason T. LOWE, Johannes H. VOIGT, Matthew NETHERTON
  • COMPOUNDS AND USES THEREOF
    Publication number: 20230416246
    Abstract: The present invention relates to compositions and methods for the treatment of BAF-related disorders, such as cancers and viral infections.
    Type: Application
    Filed: June 29, 2023
    Publication date: December 28, 2023
    Inventors: Sabine K. RUPPEL, Zhaoxia YANG, Jason T. LOWE, Johannes H. VOIGT, Matthew NETHERTON
  • Compounds and uses thereof
    Patent number: 11851445
    Abstract: The present disclosure features compounds useful for the treatment of BAF complex-related disorders.
    Type: Grant
    Filed: January 29, 2021
    Date of Patent: December 26, 2023
    Assignee: FOGHORN THERAPEUTICS INC.
    Inventors: Sabine K. Ruppel, Zhaoxia Yang, Jason T. Lowe, Johannes H. Voigt
  • COMPOUNDS AND USES THEREOF
    Publication number: 20230331722
    Abstract: The present invention relates to compositions and methods for the treatment of BAF-related disorders, such as cancers and viral infections.
    Type: Application
    Filed: June 29, 2023
    Publication date: October 19, 2023
    Inventors: Sabine K. RUPPEL, Zhaoxia YANG, Jason T. LOWE, Johannes H. VOIGT, Matthew NETHERTON
  • BRD9 degraders and uses thereof
    Patent number: 11787800
    Abstract: The present invention relates to methods and compositions for the treatment of BAF-related disorders such as cancers and viral infections.
    Type: Grant
    Filed: July 22, 2021
    Date of Patent: October 17, 2023
    Assignee: Foghorn Therapeutics Inc.
    Inventors: Sabine K. Ruppel, Zhaoxia Yang, Jason T. Lowe, Johannes H. Voigt, Matthew Netherton, Francois Brucelle
  • Methods and compounds for treating disorders
    Patent number: 11773085
    Abstract: The present invention relates to methods and compositions for the treatment of BAF-related disorders such as cancers and viral infections.
    Type: Grant
    Filed: July 29, 2020
    Date of Patent: October 3, 2023
    Assignee: Foghorn Therapeutics Inc.
    Inventors: Qianhe Zhou, Michael Bocker, David Simon Millan, Ho Man Chan, Luis Soares, Matthew Russell Netherton, Sabine K. Ruppel, Zhaoxia Yang, Jason T. Lowe, Francois Brucelle
  • CERTAIN ARYL PLADIENOLIDE COMPOUNDS AND METHODS OF USE
    Publication number: 20230301990
    Abstract: The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancer, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.
    Type: Application
    Filed: March 7, 2023
    Publication date: September 28, 2023
    Applicant: Eisai R&D Management Co., Ltd.
    Inventors: Andrew COOK, Dominic REYNOLDS, Cheng ZHONG, Ryan BRAWN, Shelby ELLERY, Thiwanka SAMARAKOON, Xiang LIU, Sudeep PRAJAPATI, Megan SHEEHAN, Jason T. LOWE, James PALACINO
  • Certain aryl pladienolide compounds and methods of use
    Patent number: 11679107
    Abstract: The present disclosure provides pladienolide compounds, pharmaceutical compositions containing such compounds, and pladienolide compounds for use in methods of medical treatment. These compounds may be useful in the treatment of cancer, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful.
    Type: Grant
    Filed: April 11, 2019
    Date of Patent: June 20, 2023
    Assignee: EISAI R&D MANAGEMENT CO., LTD.
    Inventors: Andrew Cook, Dominic Reynolds, Cheng Zhong, Ryan Brawn, Shelby Ellery, Thiwanka Samarakoon, Xiang Liu, Sudeep Prajapati, Megan Sheehan, Jason T. Lowe, James Palacino
  • COMPOUNDS AND USES THEREOF
    Publication number: 20230142883
    Abstract: The present invention relates to compositions and methods for the treatment of BAF-related disorders, such as cancers and viral infections.
    Type: Application
    Filed: September 19, 2022
    Publication date: May 11, 2023
    Inventors: Sabine K. RUPPEL, Zhaoxia Yang, Jason T. Lowe, Johannes H. Voigt, Matthew Russell Netherton
  • COMPOUNDS AND USES THEREOF
    Publication number: 20230077730
    Abstract: The present invention relates to methods and compositions for the treatment of BAF-related disorders such as cancers and viral infections.
    Type: Application
    Filed: January 29, 2020
    Publication date: March 16, 2023
    Applicants: Foghorn Therapeutics Inc., Foghorn Therapeutics Inc.
    Inventors: Sabine K. RUPPEL, Zhaoxia YANG, Jason T. LOWE, Johannes H. VOIGT, Matthew NETHERTON, Francois BRUCELLE
  • COMPOUNDS AND USES THEREOF
    Publication number: 20230072053
    Abstract: The present disclosure features compounds useful for the treatment of BAF complex-related disorders.
    Type: Application
    Filed: January 29, 2021
    Publication date: March 9, 2023
    Inventors: Sabine K. RUPPEL, Zhaoxia YANG, Jason T. LOWE, Johannes H. VOIGT
  • COMPOUNDS AND USES THEREOF
    Publication number: 20230065463
    Abstract: The present invention relates to compositions and methods for the treatment of BAF-related disorders, such as cancers and viral infections.
    Type: Application
    Filed: January 29, 2020
    Publication date: March 2, 2023
    Inventors: Sabine K. RUPPEL, Zhaoxia YANG, Jason T. LOWE, Johannes H. VOIGT, Matthew NETHERTON, Francois BRUCELLE
  • COMPOUNDS AND USES THEREOF
    Publication number: 20230066136
    Abstract: The present invention relates to compositions and methods for the treatment of BAF-related disorders, such as cancers and viral infections.
    Type: Application
    Filed: January 29, 2020
    Publication date: March 2, 2023
    Inventors: Sabine K. RUPPEL, Zhaoxia YANG, Jason T. LOWE, Johannes H. VOIGT, Matthew NETHERTON