Abstract: Disclosed herein are human antibody molecules that immunospecifically bind to human CXCR2. The disclosed human antibody molecules are potent and selective antagonists of CXCR2 functions and prevent the recruitment of neutrophils into tissues without strongly depleting circulating neutrophil numbers. Pharmaceutical compositions, nucleic acid molecules, vectors, cells, and uses of the disclosed antibodies are also provided.

Abstract: A content management system interface at a local computer device configured to receive user file commands from a file manager and translate the user file commands into content management commands for sending to the remote content management system via a network interface. The content management system interface is further configured to receive remote file information from the remote content management system via the network interface and translate the remote file information into user file information for the file manager.

Abstract: A method of generating an accurate speaker representation for an audio sample includes receiving a first audio sample from a first speaker and a second audio sample from a second speaker. The method includes dividing a respective audio sample into a plurality of audio slices. The method also includes, based on the plurality of slices, generating a set of candidate acoustic embeddings where each candidate acoustic embedding includes a vector representation of acoustic features. The method further includes removing a subset of the candidate acoustic embeddings from the set of candidate acoustic embeddings. The method additionally includes generating an aggregate acoustic embedding from the remaining candidate acoustic embeddings in the set of candidate acoustic embeddings after removing the subset of the candidate acoustic embeddings.

Abstract: An example method to generate a video from multiple cameras including a digital X-ray imaging device involves: initiating a recording session on an X-ray digital imaging device; capturing one or more images using a first one of a plurality of imaging sensors of the X-ray digital imaging device; capturing one or more videos using a second one of the plurality of imaging sensors; storing, on a machine readable storage device, two or more files corresponding to the one or more images and the one or more videos captured using the first and second ones of the plurality of imaging sensors; and combining the two or more files into a single video file representative of the recording session.

Abstract: A traveling relief valve for down-hole use in a well. In one embodiment, the traveling relief valve comprises a seat, a screw, a seal, a carrier, a spring, and a ported tube, where the traveling relief valve is configured to include a first flow interface between the seat and the carrier for flow when the well is producing, and a second flow interface between the seal and the carrier for back-flow in the well.

Abstract: An interface in accordance with present embodiments includes a base and a theme portion disposed on the base. A first layer is disposed on the base and includes a mixture with metallic powder suspended within a translucent medium. A second layer is disposed on the base over the first layer and over the theme portion, and includes the mixture. A third layer is disposed on the base and on the theme portion over only portions of the second layer. The third layer includes paint and paint thinner. A fourth layer is disposed on the theme portion over the third layer and exposed portions of the second layer. The fourth layer also includes the mixture.

Abstract: Systems and methods for controlling operation of a well, of which the method includes receiving an operation setting for operation of a system that provides lift gas into and produces gas from the well, monitoring operation of the system using a first controller, determining, using the first controller, that the system is not operating at the operation setting, and in response to determining that the system is not operating at the operation setting, sending, using a two-way communication link from the first controller to a second controller, a control signal to the second controller. The control signal is configured to cause the second controller to modify an operation of a compressor of the system.

Abstract: Provided are modified arenaviruses and populations thereof, wherein the modified arenaviruses include i) an introduced PPXY domain; ii) an increased number of PPXY domains; iii) a substituted amino acid in place of S41 in a viral Z protein that is not a substrate for a serine or tyrosine kinase, or a combination of i)-iii). A PPXY domain can include a phosphomimetic replacement of the Y amino acid. Modified Old World and New World arenaviruses are included. Arenavirus production is provided using cell cultures that contain a kinase inhibitor that inhibits a kinase that can phosphorylate the Y amino acid of the PPXY domain, or by cells that have disrupted kinase gene expression, or by cells that have a disrupted ESCRT system. Also provided are pharmaceutical formulations that contain modified arenaviruses, and methods of using such formulations for stimulating an immune response hat is fully or partially protective against arenavirus infection.

Abstract: A system for isolating a target molecule from a bioprocess fluid includes a single-use disposable separation device having a plurality of perimeter-bonded layers defining one or more mesofluidic channels of the separation device, wherein each layer includes a biocompatible polymer material, wherein the separation device is configured to separate at least a portion of particles from the bioprocess fluid to generate a substantially clarified bioprocess fluid, and a chromatography system fluidically coupled at the outflow of the separation device in a configuration for further processing the clarified bioprocess fluid.

Abstract: Systems and methods for selecting an audio track by performing a gesture on a track-list image are provided. The system includes a processor that performs a method including displaying the audio-track list, detecting a contact with the touchscreen display at a location corresponding to the audio track, detecting a continuous movement of the contact in a direction, detecting a length of the continuous movement, and selecting the audio track if the continuous movement has a length longer than a threshold length. The method includes shifting text associated with the audio track based on the length and direction of the continuous movement. The method includes determining that the selection is a command to queue the audio track for playback or add it to a preparation track list. This determination may be based on the direction of the continuous movement.

Abstract: A content management system interface at a local computer device configured to receive user file commands from a file manager and translate the user file commands into content management commands for sending to the remote content management system via a network interface. The content management system interface is further be configured to receive remote file information from the remote content management system via the network interface and translate the remote file information into user file information for the file manager.

Abstract: A wrench assembly, and methods of making and using such a wrench assembly, whereby the wrench assembly includes a head, an opening disposed within the head, a first pivotal member coupled to the head, a plurality of radial slots inwardly extending into the first pivotal member, and a handle, whereby the head pivotally couples to the handle.

Abstract: A wellhead monitoring system includes a conversion assembly, the conversion assembly including an actuator element for modifying an operating mode of a valve from manual to remote. The system also includes one or more sensors, associated at least one of a fracturing tree or the conversion assembly, the one or more sensors obtaining wellhead operating conditions. The system further includes a control unit, adapted to receive information from the one or more sensors, the control unit presenting the information, on a display, and transmitting the information to a remote system for analysis.

Abstract: Parenteral delivery of a beneficial agent using an auto-injector configured for reduction of forces acting on a primary container for the beneficial agent during activation of the auto-injector. The primary container may be disposed within a pressure chamber of the auto-injector such that an increased pressure within the pressure chamber during activation is applied to a stopper of the primary container and an external surface of a sidewall of the primary container. In turn, a pressure differential between a containment volume of the primary container and the pressure chamber may be reduced or eliminated. In turn, forces acing on the primary container in response to the pressure increase in the pressure container may be reduced or eliminated. Configurations are also provided for improved relative movement between a stopper and a sidewall of the primary container for more reliable injection.

Abstract: A cognitive state amelioration method, system, and computer program product, include predicting a cognitive state of a user based on at least one of a plurality of inputs including a physiological state of the user, a gesture of the user, a speech pattern of the user, and an internal state status of the user received from a second user, performing an ameliorating action to treat the cognitive state of the user when the predicting predicts a negative type of the cognitive state, and learning an effectiveness of the ameliorating action for treating the negative type of the cognitive state for the predicting to predict a different cognitive state, thereby to dictate a different ameliorating action to treat the different cognitive state more effectively.

Abstract: Vertical transmission line probes having alternating capacitive and inductive sections are provided. These alternating sections can be designed to provide a desired transmission line impedance (e.g., between 10 and 100 Ohms, preferably 50 Ohms). Probe flexure in operation is mainly in the inductive sections, advantageously reducing flexure stresses on the dielectrics in the capacitive sections.

Abstract: Systems and methods for controlling operation of a well, of which the method includes receiving an operation setting for operation of a system that provides lift gas into and produces gas from the well, monitoring operation of the system using a first controller, determining, using the first controller, that the system is not operating at the operation setting, and in response to determining that the system is not operating at the operation setting, sending, using a two-way communication link from the first controller to a second controller, a control signal to the second controller. The control signal is configured to cause the second controller to modify an operation of a compressor of the system.

Abstract: The present invention provides an asymmetric modified CMS hollow fiber membrane having improved gas separation performance properties and a process for preparing an asymmetric modified CMS hollow fiber membrane having improved gas separation performance properties. The process comprises treating a polymeric precursor fiber with a solution containing a modifying agent prior to pyrolysis. The concentration of the modifying agent in the solution may be selected in order to obtain an asymmetric modified CMS hollow fiber membrane having a desired combination of gas permeance and selectivity properties. The treated precursor fiber is then pyrolyzed to form an asymmetric modified CMS hollow fiber membrane having improved gas permeance.

Abstract: A wellhead monitoring system includes a conversion assembly, the conversion assembly including an actuator element for modifying an operating mode of a valve from manual to remote. The system also includes one or more sensors, associated at least one of a fracturing tree or the conversion assembly, the one or more sensors obtaining wellhead operating conditions. The system further includes a control unit, adapted to receive information from the one or more sensors, the control unit presenting the information, on a display, and transmitting the information to a remote system for analysis.

Abstract: A rod-pump control device is disclosed. The rod-pump control device uses AMP (current) measurements for electric units, fuel or air usage for gas units, and can use pressure for either unit. The AMP/fuel/air sensors work as the primary trigger to indicate a pump-off condition on an oil and gas well. These sensors can be used as stand-alone triggers or in conjunction with other sensors to more accurately monitor pump efficiency. When the pump-controller starts to indicate an inefficient pump condition, it will turn the pump off by removing power from the electric motor. For gas powered units, the controller will remove power to disengage an electric clutch or send a signal to an engine controller to stop. An adjustable algorithm will use percentage change of off time, dependent on actual run time compared to a user definable target time to keep the pump operating at peak efficiency.