Patents by Inventor Javier Alarcón
Javier Alarcón has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11672907Abstract: Provided herein are devices, systems, and methods for the removal of preservatives/excipients/stabilizers from pharmaceutical preparations/medicaments. The devices and systems include a resin for the filtering of preservatives from pharmaceutical preparations. The methods allow for a period of time of incubation of the pharmaceutical preparation in the resin that effectively removes preservatives, while at the same time maintaining the required amount or concentration of active compound in the preparation. Also provided herein are devices, systems, and methods for the controlled release of anti-inflammatory agents in an insulin infusion set.Type: GrantFiled: May 1, 2018Date of Patent: June 13, 2023Assignee: Becton, Dickinson and CompanyInventors: Matthew Novak, Alfred J. Harvey, Douglas B. Sherman, Robert J. Radford, Javier Alarcon, Ronald J. Pettis, Kelly Magee Riley
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Publication number: 20200147300Abstract: Provided herein are devices, systems, and methods for the removal of preservatives/excipients/stabilizers from pharmaceutical preparations/medicaments. The devices and systems include a resin for the filtering of preservatives from pharmaceutical preparations. The methods allow for a period of time of incubation of the pharmaceutical preparation in the resin that effectively removes preservatives, while at the same time maintaining the required amount or concentration of active compound in the preparation. Also provided herein are devices, systems, and methods for the controlled release of anti-inflammatory agents in an insulin infusion set.Type: ApplicationFiled: May 1, 2018Publication date: May 14, 2020Applicant: Becton, Dickinson and CompanyInventors: Matthew NOVAK, Alfred J. HARVEY, Douglas B. SHERMAN, Robert J. RADFORD, Javier ALARCON, Ronald J. PETTIS, Kelly Magee RILEY
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Publication number: 20170114200Abstract: Methods for adhering a hydrogel matrix to a molded polymer substrate and its use as a biosensor, e.g., a continuous or episodic glucose monitor, are disclosed. The presently disclosed subject mater provides a method for adhering a hydrogel matrix to a molded polymer substrate, the method comprising; (a) molding a polymer comprising one or more polymer chains with an oxidizer to form a molded polymer substrate; (b) providing a hydrogel matrix comprising a hydrogel, a component comprising one or more acrylate groups or another functional group that can form one or more radicals upon polymerization in the molded polymer substrate, and a photo initiator; (c) combining the molded polymer substrate and the hydrogel matrix; and (d) curing the combined molded polymer substrate and hydrogel matrix for a period of fime.Type: ApplicationFiled: December 16, 2016Publication date: April 27, 2017Inventor: Javier ALARCON
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Patent number: 9574057Abstract: Methods for adhering a hydrogel matrix to a molded polymer substrate and its use as a biosensor, e.g., a continuous or episodic glucose monitor, are disclosed. The presently disclosed subject matter provides a method for adhering a hydrogel matrix to a molded polymer substrate, the method comprising: (a) molding a polymer comprising one or more polymer chains with an oxidizer to form a molded polymer substrate; (b) providing a hydrogel matrix comprising a hydrogel, a component comprising one or more acrylate groups or another functional group that can form one or more radicals upon polymerization in the molded polymer substrate, and a photo initiator; (c) combining the molded polymer substrate and the hydrogel matrix; and (d) curing the combined molded polymer substrate and hydrogel matrix for a period of time.Type: GrantFiled: March 28, 2013Date of Patent: February 21, 2017Assignee: Becton, Dickinson and CompanyInventor: Javier Alarcon
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Patent number: 9068565Abstract: A container and method for storing a pharmaceutical agent are provided for enhancing the storage time. The storage time of the pharmaceutical agent is improved by reducing the loss of stabilizing agents in the pharmaceutical agent. The storage container is formed from a polyolefin that includes a stabilizing agent in an amount effective to reduce or inhibit the migration of stabilizing agents in the pharmaceutical agent. The polyolefin container is formed with a fatty acid amide such as erucamide for stabilizing insulin that contains m-cresol and/or phenol as stabilizing agents for the insulin. The fatty acid amide incorporated in the container inhibits and/or reduces the rate of migration of the m-cresol and/or phenol into the polyolefin to extend the storage life of the insulin. The container can be a syringe, such as a pre-filled syringe, a storage vial or the flow path of an infusion pump.Type: GrantFiled: May 3, 2012Date of Patent: June 30, 2015Assignee: BECTON, DICKINSON AND COMPANYInventors: Javier Alarcon, William Riggsbee, Joshua Horvath, Dinesh Kommireddy, Ron J. Pettis
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Publication number: 20150056634Abstract: Methods and compositions for preparing dry formulations of Glucose Binding Proteins (GBPs) are disclosed. The GBPs may be stored as a dry formulation without significant loss of activity. After reconstitution, the GBPs may be used to determine the glucose concentration of a sample.Type: ApplicationFiled: March 28, 2013Publication date: February 26, 2015Applicant: Becton, Dickinson and CompanyInventors: Matthew S. Ferriter, Javier Alarcon, Glenn P. Vonk, Melody M.H. Kuroda, Mark Foster Sistare, Brandi Marie Ford
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Publication number: 20150025170Abstract: Methods for adhering a hydrogel matrix to a molded polymer substrate and its use as a biosensor, e.g., a continuous or episodic glucose monitor, are disclosed. The presently disclosed subject matter provides a method for adhering a hydrogel matrix to a molded polymer substrate, the method comprising: (a) molding a polymer comprising one or more polymer chains with an oxidizer to form a molded polymer substrate; (b) providing a hydrogel matrix comprising a hydrogel, a component comprising one or more acrylate groups or another functional group that can form one or more radicals upon polymerization in the molded polymer substrate, and a photo initiator; (c) combining the molded polymer substrate and the hydrogel matrix; and (d) curing the combined molded polymer substrate and hydrogel matrix for a period of time.Type: ApplicationFiled: March 28, 2013Publication date: January 22, 2015Applicant: Becton, Dickinson and CompanyInventor: Javier Alarcon
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Publication number: 20150018641Abstract: A device for sensing analyte concentration, and in particular glucose concentration, in vivo or in vitro is disclosed. A sensing element is attached to the distal end of an optical conduit, and comprises at least one binding protein adapted to bind with at least one target analyte. The sensing element further comprises at least one reporter group that undergoes a luminescence change with changing analyte concentrations. Optionally, the optical conduit and sensing element may be housed within a cannulated bevel.Type: ApplicationFiled: July 1, 2013Publication date: January 15, 2015Applicant: Becton, Dickinson and CompanyInventors: Javier Alarcon, Kristin Weidemaier, Terry J. Amiss, John D. DeNuzzio, Christopher C. Herdman, Ross W. Jacobson, J. Bruce Pitner, Douglas B. Sherman
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Publication number: 20130296235Abstract: A container and method for storing a pharmaceutical agent are provided for enhancing the storage time. The storage time of the pharmaceutical agent is improved by reducing the loss of stabilizing agents in the pharmaceutical agent. The storage container is formed from a polyolefin that includes a stabilizing agent in an amount effective to reduce or inhibit the migration of stabilizing agents in the pharmaceutical agent. The polyolefin container is formed with a fatty acid amide such as erucamide for stabilizing insulin that contains m-cresol and/or phenol as stabilizing agents for the insulin. The fatty acid amide incorporated in the container inhibits and/or reduces the rate of migration of the m-cresol and/or phenol into the polyolefin to extend the storage life of the insulin. The container can be a syringe, such as a pre-filled syringe, a storage vial or the flow path of an infusion pump.Type: ApplicationFiled: May 3, 2012Publication date: November 7, 2013Applicant: BECTON, DICKINSON AND COMPANYInventors: Javier ALARCON, William RIGGSBEE, Joshua HORVATH, Dinesh KOMMIREDDY, Ron J. PETTIS
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Publication number: 20110184259Abstract: A device for sensing analyte concentration, and in particular glucose concentration, in vivo or in vitro is disclosed. A sensing element is attached to the distal end of an optical conduit, and comprises at least one binding protein adapted to bind with at least one target analyte. The sensing element further comprises at least one reporter group that undergoes a luminescence change with changing analyte concentrations. Optionally, the optical conduit and sensing element may be housed within a cannulated bevel.Type: ApplicationFiled: August 23, 2010Publication date: July 28, 2011Inventors: Javier Alarcon, Kristin Weidemaier, Terry J. Amiss, John D. DeNuzzio, Christopher C. Herdman, Ross W. Jacobson, J. Bruce Pitner, Douglas B. Sherman, Steven Keith
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Patent number: 7792561Abstract: A device for sensing analyte concentration, and in particular glucose concentration, in vivo or in vitro is disclosed. An optical conduit, preferably an optical fiber has an optical system at the proximal end of the optical conduit. A sensing element is attached to the distal end of the optical conduit, and comprises at least one binding protein adapted to bind with at least one target analyte. The sensing element further comprises at least one reporter group that undergoes a luminescence change with changing analyte concentrations. Optionally, the sensing element includes reference groups with luminescence properties that are substantially unchanged by variations in the analyte concentrations.Type: GrantFiled: August 16, 2007Date of Patent: September 7, 2010Assignee: Becton, Dickinson and CompanyInventors: Javier Alarcon, Kristin Weidemaier, Terry J. Amiss, John D. Denuzzio, Christopher C. Herdman, Ross Wayne Jacobson, J. Bruce Pitner, Douglas B. Sherman
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Patent number: 7787923Abstract: A device for sensing analyte concentration, and in particular glucose concentration, in vivo or in vitro is disclosed. A sensing element is attached to the distal end of an optical conduit, and comprises at least one binding protein adapted to bind with at least one target analyte. The sensing element further comprises at least one reporter group that undergoes a luminescence change with changing analyte concentrations. Optionally, the optical conduit and sensing element may be housed within a cannulated bevel.Type: GrantFiled: October 19, 2004Date of Patent: August 31, 2010Assignee: Becton, Dickinson and CompanyInventors: Javier Alarcon, Kristin Weidemaier, Terry J. Amis, John D. DeNuzzio, Christopher C. Herdman, Ross W. Jacobson, J. Bruce Pitner, Douglas B. Sherman, Steven Keith
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Patent number: 7629172Abstract: The invention is directed to entrapped mutated binding proteins, mutated binding proteins containing reporter groups, compositions of mutated binding proteins containing reporter groups in analyte permeable matrixes, and their use as analyte biosensors both in vitro and in vivo.Type: GrantFiled: September 27, 2004Date of Patent: December 8, 2009Assignee: Becton, Dickinson and CompanyInventors: Javier Alarcon, Christopher J. Knors, J. Bruce Pitner
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Publication number: 20090232700Abstract: The present invention relates to methods of making a sterilized biosensor, where the biosensor comprises at least one binding reagent, which comprises at least one non-enzyme proteinaceous binding domain. Certain embodiments of the methods described herein comprise partially assembling the components of the biosensor, except for the binding reagent, and separately sterilizing this partial assemblage and the binding reagent. The sterilized binding reagent and the sterilized partial assemblage are then aseptically assembled to produce the sterilized biosensor. Other embodiments of the methods described herein comprise assembling substantially all of the components of the biosensor, including the binding reagent, and sterilizing the assembled biosensor to produce a sterilized biosensor.Type: ApplicationFiled: May 12, 2009Publication date: September 17, 2009Inventors: Javier Alarcon, Kristin Weidemaier, David M. Kurisko, Srinivasan Sridharan
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Patent number: 7496392Abstract: A device for sensing analyte concentration, and in particular glucose concentration, in vivo or in vitro is described. An optical conduit, preferably an optical fiber, has an optical system at the proximal end of the optical conduit. A sensing element is attached to the distal end of the optical conduit, and may include at least one binding protein adapted to bind with at least one target analyte. The sensing element further may also include at least one reporter group that undergoes a luminescence change with changing analyte concentrations. Optionally, the sensing element includes reference groups with luminescence properties that are substantially unchanged by variations in the analyte concentrations.Type: GrantFiled: November 26, 2003Date of Patent: February 24, 2009Assignee: Becton, Dickinson and CompanyInventors: Javier Alarcón, Kristin Weidemaier, Terry J. Amiss, John D. DeNuzzio, Christopher C. Herdman, Ross Wayne Jacobson, J. Bruce Pitner, Douglas B. Sherman
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Publication number: 20080275318Abstract: The invention relates to methods and devices for measuring blood glucose levels in a subject, where the methods and devices are designed for exposing a sensing mechanism to interstitial fluid in the subject.Type: ApplicationFiled: April 21, 2008Publication date: November 6, 2008Applicant: Becton, Dickinson and CompanyInventors: Alexander LASTOVICH, Jacob Hartsell, Javier Alarcon, Glenn Vonk, Bruce Clyde Roberts
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Publication number: 20080198358Abstract: A device for sensing analyte concentration, and in particular glucose concentration, in vivo or in vitro is disclosed. An optical conduit, preferably an optical fiber has an optical system at the proximal end of the optical conduit. A sensing element is attached to the distal end of the optical conduit, and comprises at least one binding protein adapted to bind with at least one target analyte. The sensing element further comprises at least one reporter group that undergoes a luminescence change with changing analyte concentrations. Optionally, the sensing element includes reference groups with luminescence properties that are substantially unchanged by variations in the analyte concentrations.Type: ApplicationFiled: August 16, 2007Publication date: August 21, 2008Inventors: Javier Alarcon, Kristin Weidemaier, Terry J. Amiss, John D. Denuzzio, Christopher C. Herdman, Ross Wayne Jacobson, J. Bruce Pitner, Douglas B. Sherman
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Publication number: 20070111196Abstract: The present invention relates to methods of making a sterilized biosensor, where the biosensor comprises at least one binding reagent, which comprises at least one non-enzyme proteinaceous binding domain. Certain embodiments of the methods described herein comprise partially assembling the components of the biosensor, except for the binding reagent, and separately sterilizing this partial assemblage and the binding reagent. The sterilized binding reagent and the sterilized partial assemblage are then aseptically assembled to produce the sterilized biosensor. Other embodiments of the methods described herein comprise assembling substantially all of the components of the biosensor, including the binding reagent, and sterilizing the assembled biosensor to produce a sterilized biosensor.Type: ApplicationFiled: August 21, 2006Publication date: May 17, 2007Inventors: Javier Alarcon, Kristin Weidemaier, David Kurisko, Srinivasan Sridharan
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Publication number: 20050239155Abstract: The invention is directed to binding proteins, proteins comprising reporter groups, compositions of binding molecules comprising reporter groups in analyte permeable matrices, and their use as analyte biosensors both in vitro and in vivo.Type: ApplicationFiled: March 11, 2005Publication date: October 27, 2005Inventors: Javier Alarcon, J. Pitner, Wensheng Cai
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Publication number: 20050113658Abstract: A device for sensing analyte concentration, and in particular glucose concentration, in vivo or in vitro is disclosed. A sensing element is attached to the distal end of an optical conduit, and comprises at least one binding protein adapted to bind with at least one target analyte. The sensing element further comprises at least one reporter group that undergoes a luminescence change with changing analyte concentrations. Optionally, the optical conduit and sensing element may be housed within a cannulated bevel.Type: ApplicationFiled: October 19, 2004Publication date: May 26, 2005Inventors: Ross Jacobson, Kristin Weidemaier, Javier Alarcon, Christopher Herdman, Steven Keith