Patents by Inventor Javier Lopez-Prieto

Javier Lopez-Prieto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Integrated electrical profiling system for measuring leukocytes activation from whole blood
    Patent number: 10098581
    Abstract: A system includes a microfluidic device configured to isolate one or more particles from a mixture, a flow rate matching device configured to match flow rate of the microfluidic device with flow rate of an electrical measurement device configured to measure an electrical property of the isolated particles, and an electrical measurement device configured to measure an electrical property of the isolated particles.
    Type: Grant
    Filed: January 16, 2015
    Date of Patent: October 16, 2018
    Assignee: Massachusetts Institute of Technology
    Inventors: Joel Voldman, Hao-Wei Su, Javier Lopez Prieto, Jongyoon Han, Lidan Wu
  • Real-time, label-free detection of macromolecules in droplets based on electrical measurements
    Patent number: 9896725
    Abstract: A method for detecting presence of a macromolecule of interest in a test droplet. A set of detection electrodes are provided in contact with a fluidic channel. The test droplet is provided in vicinity of the detection electrodes through the fluidic channel. An alternate current (AC) power at a first frequency is applied across the set of detection electrodes. A first measurement value that reflects electrical characteristics (e.g., impedance) of the test droplet at the first frequency is obtained. This value is compared with a corresponding reference value, wherein the corresponding reference value is obtained by measuring a reference droplet containing the macromolecule of interest or free of the macromolecule at the first frequency. The presence of the macromolecule in the test droplet is thus determined based on the comparison.
    Type: Grant
    Filed: May 11, 2015
    Date of Patent: February 20, 2018
    Assignee: The Regents of the University of California Corporation
    Inventors: Abraham P. Lee, Javier Lopez-Prieto, Robert Lin, Melinda Simon
  • Integrated Electrical Profiling System For Measuring Leukocytes Activation From Whole Blood
    Publication number: 20160331297
    Abstract: A system includes a microfluidic device configured to isolate one or more particles from a mixture, a flow rate matching device configured to match flow rate of the microfluidic device with flow rate of an electrical measurement device configured to measure an electrical property of the isolated particles, and an electrical measurement device configured to measure an electrical property of the isolated particles.
    Type: Application
    Filed: January 16, 2015
    Publication date: November 17, 2016
    Inventors: Joel Voldman, Hao-Wei Su, Javier Lopez Prieto, Jongyoon Han, Lidan Wu
  • REAL-TIME, LABEL-FREE DETECTION OF MACROMOLECULES IN DROPLETS BASED ON ELECTRICAL MEASUREMENTS
    Publication number: 20150322487
    Abstract: A method for detecting presence of a macromolecule of interest in a test droplet. A set of detection electrodes are provided in contact with a fluidic channel. The test droplet is provided in vicinity of the detection electrodes through the fluidic channel. An alternate current (AC) power at a first frequency is applied across the set of detection electrodes. A first measurement value that reflects electrical characteristics (e.g., impedance) of the test droplet at the first frequency is obtained. This value is compared with a corresponding reference value, wherein the corresponding reference value is obtained by measuring a reference droplet containing the macromolecule of interest or free of the macromolecule at the first frequency. The presence of the macromolecule in the test droplet is thus determined based on the comparison.
    Type: Application
    Filed: May 11, 2015
    Publication date: November 12, 2015
    Inventors: Abraham P. LEE, Javier LOPEZ-PRIETO, Robert LIN, Melinda SIMON
  • Real-time, label-free detection of nucleic acid amplification in droplets using impedance spectroscopy and solid-phase substrate
    Patent number: 9030215
    Abstract: A method for detecting presence of nucleic acid amplification in a test droplet. A set of detection electrodes are provided in contact with a fluidic channel. The test droplet is provided in vicinity of the detection electrodes through the fluidic channel. An alternate current (AC) power at a first frequency is applied across the set of detection electrodes. A first measurement value that reflects electrical impedance of the test droplet at the first frequency is obtained. This value is compared with a corresponding reference value, wherein the corresponding reference value is obtained by measuring a reference droplet containing known amplified nucleic acid or known unamplified nucleic acid at the first frequency. The presence of amplified nucleic acid in the test droplet is thus determined based on the comparison.
    Type: Grant
    Filed: October 3, 2012
    Date of Patent: May 12, 2015
    Assignee: The Regents of the University of California Corporation
    Inventors: Abraham P. Lee, Javier Lopez-Prieto, Robert Lin, Mindy Simon, Nick Martin
  • Real-time, label-free detection of nucleic acid amplification in droplets using impedance spectroscopy and solid-phase substrate
    Publication number: 20130154671
    Abstract: A method for detecting presence of nucleic acid amplification in a test droplet. A set of detection electrodes are provided in contact with a fluidic channel. The test droplet is provided in vicinity of the detection electrodes through the fluidic channel. An alternate current (AC) power at a first frequency is applied across the set of detection electrodes. A first measurement value that reflects electrical impedance of the test droplet at the first frequency is obtained. This value is compared with a corresponding reference value, wherein the corresponding reference value is obtained by measuring a reference droplet containing known amplified nucleic acid or known unamplified nucleic acid at the first frequency. The presence of amplified nucleic acid in the test droplet is thus determined based on the comparison.
    Type: Application
    Filed: October 3, 2012
    Publication date: June 20, 2013
    Inventors: Abraham P. Lee, Javier Lopez-Prieto, Robert Lin, Mindy Simon, Nick Martin