Patents by Inventor Javier Manero

Javier Manero has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7678935
    Abstract: Provided are compounds of formula A and formula I: A compound of formula A: wherein n is an integer from 6 to 17 and a compound of formula I:
    Type: Grant
    Filed: November 14, 2008
    Date of Patent: March 16, 2010
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Bernd Junker, Javier Manero
  • Patent number: 7538227
    Abstract: The present invention relates to a process for stabilizing 4-halopyridines of the formula (I) by adding a secondary and/or aliphatic or mixed aliphatic-aromatic tertiary amine, and mixtures comprising a compound of the formula (I) and a secondary and/or tertiary amine.
    Type: Grant
    Filed: January 13, 2005
    Date of Patent: May 26, 2009
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Silke Dubberke, Javier Manero
  • Publication number: 20090082589
    Abstract: Provided are compounds of formula A and formula I: A compound of formula A: wherein n is an integer from 6 to 17 and a compound of formula I:
    Type: Application
    Filed: November 14, 2008
    Publication date: March 26, 2009
    Inventors: Bernd Junker, Javier Manero
  • Publication number: 20080319221
    Abstract: Provided are compounds of formula A and formula I: A compound of formula A: wherein n is an integer from 6 to 17 and a compound of formula I:
    Type: Application
    Filed: June 22, 2007
    Publication date: December 25, 2008
    Inventors: Bernd Junker, Javier Manero
  • Publication number: 20080319218
    Abstract: Provided are compounds and a process for preparing benzyl pentahydroxyhexylcarbamoylundecanoate (I) and uses thereof.
    Type: Application
    Filed: June 22, 2007
    Publication date: December 25, 2008
    Inventors: Andreas Haubrich, Bernd Junker, Javier Manero, Theo Wollmann
  • Patent number: 7009047
    Abstract: The present invention relates to ethane-1,2-diaminium bis[(2R)-2-bromo-3-phenyl-propanoate], the preparation of ethane-1,2-diaminium bis[(2R)-2-bromo-3-phenyl-propanoate] from (2R)-2-bromo-3-phenylpropionic acid and ethylenediamine in 2-propanol, and the use of ethane-1,2-diaminium bis[(2R)-2-bromo-3-phenyl-propanoate] for the preparation of ACE/NEP inhibitors.
    Type: Grant
    Filed: March 17, 2003
    Date of Patent: March 7, 2006
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Javier Manero, Tobias Metzenthin, Rainer Gauler
  • Patent number: 6989462
    Abstract: A process is described for preparing compounds of formula (I) where R is H, optionally halogen-substituted alkyl, cycloalkyl, aryl, alkyl-aryl or heteroaryl, and, in alkyl and cycloalkyl, one or more CH2 groups may be replaced by —O—. The compounds of the formula (I) are valuable intermediates in the synthesis of PPAR agonists.
    Type: Grant
    Filed: March 18, 2004
    Date of Patent: January 24, 2006
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Claus-Jürgen Maier, Tobias Metzenthin, Joachim Graeser, Richard Bicker, Javier Manero
  • Publication number: 20050165239
    Abstract: The present invention relates to a process for stabilizing 4-halopyridines of the formula (I) by adding a secondary and/or aliphatic or mixed aliphatic-aromatic tertiary amine, and mixtures comprising a compound of the formula (I) and a secondary and/or tertiary amine.
    Type: Application
    Filed: January 13, 2005
    Publication date: July 28, 2005
    Applicant: Aventis Pharma Deutschland GmbH
    Inventors: Silke Dubberke, Javier Manero
  • Publication number: 20040192956
    Abstract: A process is described for preparing compounds of formula (I) 1
    Type: Application
    Filed: March 18, 2004
    Publication date: September 30, 2004
    Applicant: AVENTIS PHARMA DEUTSCHLAND GMBH
    Inventors: Claus-Jurgen Maier, Tobias Metzenthin, Joachim Graeser, Richard Bicker, Javier Manero
  • Publication number: 20040010039
    Abstract: The present invention relates to ethane-1,2-diaminium bis[(2R)-2-bromo-3-phenyl-propanoate], the preparation of ethane-1,2-diaminium bis[(2R)-2-bromo-3-phenyl-propanoate] from (2R)-2-bromo-3-phenylpropionic acid and ethylenediamine in 2-propanol, and the use of ethane-1,2-diaminium bis[(2R)-2-bromo-3-phenyl-propanoate] for the preparation of ACE/NEP inhibitors.
    Type: Application
    Filed: March 17, 2003
    Publication date: January 15, 2004
    Inventors: Javier Manero, Tobias Metzenthin, Rainer Gauler
  • Patent number: 6491989
    Abstract: Fluorinated naphthalene derivatives of the formula (I) R1(—A1—M1)a(—A2—M2)b—B—(—M3—A3)c—(M4—A4)d—R2  (I) where B is  having the meaning  and R1(—A1—M1)a(—A2—M2) and (—M3—A3)(M4—A4)R2 are mesogenic radicals, are suitable as components of liquid-crystal mixtures, in particular ferroelectric liquid-crystal mixtures.
    Type: Grant
    Filed: July 10, 2000
    Date of Patent: December 10, 2002
    Assignee: Aventis Reseach & Technologies GmbH & Co. KG
    Inventors: Javier Manero, Wolfgang Schmidt, Barbara Hornung
  • Patent number: 6485797
    Abstract: A ferroelectric liquid crystal mixture, especially useful for operation in the &tgr;Vmin−mode, comprises a 5-Arylindane derivative of the formula (I), wherein Y is CH, CF or N and R1(—A1—M1)a(—A2—M2)b—, (M3—A3—)cR2 are mesogenic groups.
    Type: Grant
    Filed: August 31, 2000
    Date of Patent: November 26, 2002
    Assignee: Aventis Research & Technologies GmbH & Co. KG
    Inventors: Wolfgang Schmidt, Javier Manero, Barbara Hornung, Rainer Wingen, Ayako Ogawa
  • Patent number: 6171519
    Abstract: A ferroelectric liquid crystal mixture having a negative value of &Dgr;e and allowing a high speed response and a low voltage driving, as well as a liquid crystal display devise using the crystal mixture of the invention. The ferroelectric liquid crystal mixture according to the invention comprises two or more compounds from at least two different of the following classes of compounds: A. thiadiazoles, B. phenanthrenes, C. 2-fluoropyridines, D. difluorobenzenes, E. meta-substituted aromatic compounds.
    Type: Grant
    Filed: June 29, 1998
    Date of Patent: January 9, 2001
    Assignee: Hoechst Research & Technology Deutschland GmbH & Co. KG
    Inventors: Toshiaki Nonaka, Ayako Takeichi, Li Ji, Kazuya Nagao, Rainer Wingen, Javier Manero, Barbara Hornung, Wolfgang Schmidt
  • Patent number: 6168838
    Abstract: Fluorinated phenanthrene derivatives and their use in liquid-crystalline mixtures Fluorinated phenanthrene derivatives of the formula (I) in which G is —CHF—CH2— or —CF═CH—, E1, E2, E3, E4, E5 and E6 are identical or different and are —CH—, —CF— or —N— and R1(—A1—M1)a(—A2—M2)b, (M3—A3—)c(M4—A4—)d R2 denote mesogenic radicals are suitable as components for liquid-crystalline mixtures, especially ferroelectric mixtures.
    Type: Grant
    Filed: August 19, 1999
    Date of Patent: January 2, 2001
    Assignee: Aventis Research & Technologies GmbH & Co. KG
    Inventors: Wolfgang Schmidt, Javier Manero
  • Patent number: 6159392
    Abstract: 5,7-Difluoro-1,2,3,4-tetrahydronaphthalene derivatives of the formula (I)R.sup.1 (-A.sup.1 -M.sup.1).sub.a (-A.sup.2 -M.sup.2).sub.b -B(-M.sup.3 -A.sup.3).sub.c (-M.sup.4 -A.sup.4).sub.d -R.sup.2 (I)in whichB isand ##STR1## R.sup.1 (-A.sup.1 -M.sup.1).sub.a (-A.sup.2 -M.sup.2) and (-M.sup.3 -A.sup.3).sub.c (-M.sup.4 -A.sup.4)R.sup.2 denote mesogenic radicals are suitable as components of liquid-crystal mixtures, in particular ferroelectric.
    Type: Grant
    Filed: August 20, 1999
    Date of Patent: December 12, 2000
    Assignee: Aventis Research & Technologies GmbH & Co. KG
    Inventors: Wolfgang Schmidt, Javier Manero
  • Patent number: 6159561
    Abstract: 1,3-Difluoronaphthalene derivatives of the formula (I)R.sup.1 (--A.sup.1 --M.sup.1).sub.a (--A.sup.2 --M.sup.2).sub.b --B(--M.sup.3 --A.sup.3).sub.c (--M.sup.4 --A.sup.4).sub.d --R.sup.2 (I)in whichB is ##STR1## and R.sup.1 (--A.sup.1 --M.sup.1).sub.a (--A.sup.2 --M.sup.2) and (--M.sup.3 --A.sup.3)(--M.sup.4 --A.sup.4)R.sup.2 denote mesogenic radicals are suitable as components for liquid-crystal mixtures, especially ferroelectric mixtures.
    Type: Grant
    Filed: August 16, 1999
    Date of Patent: December 12, 2000
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Wolfgang Schmidt, Javier Manero
  • Patent number: 6129958
    Abstract: A chiral smectic liquid crystal mixture, especially useful for operation in the .tau.V.sub.min -mode, comprises a substituted 1,2-difluornaphthaline derivatives of the formula (I),R.sup.1 (--A.sup.1 --M.sup.1).sub.a (--A.sup.2 --M.sup.2).sub.b --B--(M.sup.3 --A.sup.3 --).sub.c (M.sup.4 --A.sup.4 --).sub.d R.sup.2 (I)wherein the symbols and indices have the following meanings:B is ##STR1## or ##STR2## X is H or F; Y is H, F or together O, andR.sup.1 (--A.sup.1 --M.sup.1).sub.a (--A.sup.2 --M.sup.2).sub.b --, (M.sup.3 --A.sup.3 --).sub.c (M.sup.4 --A.sup.4 --).sub.d R.sup.2 are mesogenic groups.
    Type: Grant
    Filed: October 26, 1998
    Date of Patent: October 10, 2000
    Assignee: Hoechst Reasearch & Technology Deutschland GmbH & Co. KG
    Inventors: Wolfgang Schmidt, Javier Manero, Barbara Hornung
  • Patent number: 6120703
    Abstract: 5-Fluorophenanthridine derivatives and their use in liquid-crystalline mixtures 6-Fluorophenanthridine derivatives of the formula (I) ##STR1## in which G is --CF.dbd.N--,E.sup.1, E.sup.2, E.sup.3, E.sup.4, E.sup.5 and E.sup.6 are identical or different and are --CH--, --CF-- or --N--and R.sup.1 (--A.sup.1 --M.sup.1).sub.a (--A.sup.2 --M.sup.2).sub.b, (M.sup.3 --A.sup.3 --).sub.c (M.sup.4 --A.sup.4 --).sub.d R.sup.2 denote mesogenic radicalsare suitable as components for liquid-crystalline mixtures, especially ferroelectric mixtures.
    Type: Grant
    Filed: August 30, 1999
    Date of Patent: September 19, 2000
    Assignee: Aventis Research & Technologies Deutschland GmbH & Co. KG
    Inventors: Wolfgang Schmidt, Javier Manero
  • Patent number: 6022492
    Abstract: Difluorophenylpyrimidylpyridine derivatives of the formula (I) ##STR1## wherein X is N and Y is CH or X is CH and Y is N;R.sup.1 and R.sup.2 are identical or different and area) an unbranched or branched alkyl chain having 1 to 20 carbon atoms, whereaa) one or more non-adjacent and non-terminal CH.sub.2 groups may be replaced by --O--, --CO--O--, --O--CO--, --O--CO--O-- or --Si(CH.sub.3).sub.2 --, and/orab) one or more H atoms may be replaced by F, and/orac) the terminal CH.sub.3 group may be replaced by one of the following chiral groups (optically active or racemic): ##STR2## R.sup.3, R.sup.4 and R.sup.5 are identical or different and are hydrogen or a straight-chain or branched alkyl radical having 1-16 carbon atoms (with or without an asymmetrical carbon atom), where, in addition, one or more non-adjacent non-terminal CH.sub.2 groups may be replaced by --O--, and/or where one or more H atoms of the alkyl radical may be substituted by --F; R.sup.4 and R.sup.5 may alternatively together be --(CH.sub.2).sub.
    Type: Grant
    Filed: January 14, 1999
    Date of Patent: February 8, 2000
    Assignee: Hoescht Research & Technology Deutchland GmbH & Co.
    Inventors: Toshiaki Nonaka, Ji Li, Ayako Takeichi, Barbara Hornung, Javier Manero, Wolfgang Schmidt, Rainer Wingen
  • Patent number: 5942618
    Abstract: 1-Fluoro-5,6,7,8-tetrahydroisoquinoline derivatives, and their use in liquid-crystalline mixtures1-Fluoro-5,6,7,8-tetrahydroisoquinoline derivatives of the formula (I)R.sup.1 ( --M.sup.1).sub.a (--A.sup.1 --M.sup.2).sub.b (--A.sup.2 --M.sup.3).sub.c --B(--M.sup.4 --A.sup.3).sub.d (--M.sup.5 --A.sup.4).sub.e (--M.sup.6 .sub.f --R.sup.2 (I)in which the symbols and indices have the following meanings:the group B is ##STR1## R.sup.1 and R.sup.2 are, for example, alkyl radicals having 1 to 20 carbon atoms;M.sup.1, M.sup.2, M.sup.3, M.sup.4, M.sup.5 and M.sup.6 are, for example, --O--, --CO--O--, --O--CO-- or a single bond;A.sup.1, A.sup.2, A.sup.3 and A.sup.4 are, for example, 1,4-phenylene, pyrimidine-2,5-diyl or trans-1,4-cyclohexylene, anda, b, c, d, e and f are zero or one, with the proviso that the sum of b, c, d and e is 0, 1 or 2.
    Type: Grant
    Filed: November 6, 1997
    Date of Patent: August 24, 1999
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Javier Manero, Rainer Wingen