Abstract: Representative methods, apparatus and systems are disclosed for determining one or more physiological parameters, such as for ambulatory blood pressure and other vital sign monitoring. A representative system comprises first and second wearable apparatuses to be worn on the user's left and right sides, and any of several types of central vital signs monitors. Another representative system is a handheld, singular apparatus to be held in both hands by the user. Another representative system comprises first and second wearable apparatuses without any additional central vital signs monitor. The various embodiments measure a differential pulse arrival time of left and right arterial pressure waves using corresponding determined features, such as a foot or systolic peak, and using the measured differential pulse arrival time and calibration data, determine at least one physiological parameter such as blood pressure, heart rate, stroke rate, and cardiac output.